NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=129S6/SvEvTac, and CD-1;
TISSUE=Placenta;
DOI=10.1074/jbc.M400271200; PubMed=15234981 [NCBI, ExPASy, EBI, Israel, Japan]
Robb G.B., Carson A.R., Tai S.C., Fish J.E., Singh S., Yamada T., Scherer S.W., Nakabayashi K., Marsden P.A.;
"Post-transcriptional regulation of endothelial nitric-oxide synthase by an overlapping antisense mRNA transcript.";
J. Biol. Chem. 279:37982-37996(2004).

[2]

FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
DOI=10.1074/jbc.M413957200; PubMed=15755735 [NCBI, ExPASy, EBI, Israel, Japan]
Yamada T., Carson A.R., Caniggia I., Umebayashi K., Yoshimori T., Nakabayashi K., Scherer S.W.;
"Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast.";
J. Biol. Chem. 280:18283-18290(2005).

Comments

FUNCTION: Plays a role in autophagy.
SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in heart, brain, and placenta and testis.
SIMILARITY: Belongs to the ATG9 family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AY495541; AAS72555.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY515312; AAS87213.1; ALT_INIT; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY515313; AAS87214.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BK004021; DAA05202.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001002897.2; -.

UniGene

Mm.332252

3D structure databases

ModBase

Q6EBV9.

Organism-specific databases

MGI

MGI:2685420; Atg9b.

Gene expression databases

ArrayExpress

Q6EBV9; -.

Ontologies

GO:0005776;	Cellular component: autophagic vacuole (inferred from direct assay from MGI).
QuickGo view.

Family and domain databases

InterPro

IPR007241; Autophagy_prot_9.
Graphical view of domain structure.

PANTHER

PTHR13038; APG9; 1.

Pfam

PF04109; APG9; 1.
Pfam graphical view of domain structure.

BLOCKS

Q6EBV9.

Genome annotation databases

Ensembl

ENSMUSG00000038295; Mus musculus. [Contig view]

GeneID

213948; -.

KEGG

mmu:213948; -.

Phylogenomic databases

HOGENOM

Q6EBV9; -.

HOVERGEN

Q6EBV9; -.

Other

Atg9b; Mus musculus.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Autophagy; Cytoplasmic vesicle; Membrane; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 922`	`922`	`Autophagy-related protein 9B.`	`PRO_0000314868`
`TOPO_DOM`	`1 206`	`206`	`Cytoplasmic (By similarity).`
`TRANSMEM`	`207 227`	`21`	`Potential.`
`TOPO_DOM`	`228 275`	`48`	`Lumenal (By similarity).`
`TRANSMEM`	`276 296`	`21`	`Potential.`
`TOPO_DOM`	`297 437`	`141`	`Cytoplasmic (By similarity).`
`TRANSMEM`	`438 458`	`21`	`Potential.`
`TOPO_DOM`	`459 523`	`65`	`Lumenal (By similarity).`
`TRANSMEM`	`524 544`	`21`	`Potential.`
`TOPO_DOM`	`545 550`	`6`	`Cytoplasmic (By similarity).`
`TRANSMEM`	`551 571`	`21`	`Potential.`
`TOPO_DOM`	`572 624`	`53`	`Lumenal (By similarity).`
`TRANSMEM`	`625 645`	`21`	`Potential.`
`TOPO_DOM`	`646 922`	`277`	`Cytoplasmic (By similarity).`
`COMPBIAS`	`86 146`	`61`	`Pro-rich.`

Sequence information

Length: 922 AA [This is the length of the unprocessed precursor]

Molecular weight: 101953 Da [This is the MW of the unprocessed precursor]

CRC64: 450179EDD6C8496A [This is a checksum on the sequence]

        10         20         30         40         50         60 
MVRRTGWGGS RRQRGRWGDL GPSSVPLLHM ALPLPASPCR GTGGRRISVF SLSPAPRTRS 

        70         80         90        100        110        120 
CSSSVFPPAS GSPCLVIQEA GASQTPHNVL PTPTTPSTQA HPTMIHTSAS PSWGSHSTPP 

       130        140        150        160        170        180 
LASATPPPSC PRPQDHPGLR MGPLIPEQDY ERLEDCDPEG SQDSPIHGED HQPLLHVPEG 

       190        200        210        220        230        240 
LRGSWHHIQN LDSFFTKIYS YHQRNGFACI LLEDVFQLGQ FIFIVTFTTF LLRCVDYNVL 

       250        260        270        280        290        300 
FNNQPKNHTR RGPLHSKVTL SDAILPSAQC AEKIHDSPLL VFLLVLAAGF WLFQLLRSVC 

       310        320        330        340        350        360 
NLFSYWDIQV FYREALHIPP EELSSVPWAE VQSRLLELQR SGGLCVQPRP LTELDVHHRI 

       370        380        390        400        410        420 
LRYTNYQVAL ANKGLLPARC PLPWGSSAAF LSRGLALNVD LLLFRGPFSL FRGGWELPEA 

       430        440        450        460        470        480 
YKRSDLRGVL ANRWRRTVLL LAAVNLALSP LVLAWQVLHA FYSHVELLRR EPGAFGARRW 

       490        500        510        520        530        540 
SRLARLQLRH FNELPHELRA RLGRAYRPAA AFLRAAEPPA PLRALLARQL VFFSGALFAA 

       550        560        570        580        590        600 
LLVLTIYDED VLAVEHVLTT MTALGVTATV ARSFIPEEQC QGRSSQLLLQ AALAHMHYLP 

       610        620        630        640        650        660 
EEPGATGARA SSYWQMAQLL QYRAVSLLEE LLSPLLTPLF LLFWFRPRAL EIIDFFHHFT 

       670        680        690        700        710        720 
VDVAGVGDIC SFALMDVKRH GHPQWLSEGQ TEASLSQRAE DGKTELSLMR FSLAHPQWQP 

       730        740        750        760        770        780 
PGHSSKFLGH LRGRVQQDAA AWGAPSTRSP PTPGVLSDCT SPLPEAFLAN LLVNPRPPQR 

       790        800        810        820        830        840 
DLSPTAPCPA AATASLLASI SRMVQDPSCV SPGGTGGQKL TQLPELVSAE MSLHAIYLHQ 

       850        860        870        880        890        900 
LHQQQQQELW GEASASSPSR PWSSPSQPGS PDEEKPSWSS DGSSPASSPR QQWGTQRAQN 

       910        920 
LFPKGFQENT DTQKEPLTGP LH

Q6EBV9 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools