ID   ATG3_RAT                Reviewed;         314 AA.
AC   Q6AZ50; Q9ESH2;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   22-JUL-2008, entry version 28.
DE   RecName: Full=Autophagy-related protein 3;
DE   AltName: Full=APG3-like;
DE   AltName: Full=Preconditioning-inducible gene 1 protein;
GN   Name=Atg3; Synonyms=Apg3l;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Laser M., Li Y., Xu L., Darden A., Wu B.X., Hazard E.S. III,
RA   Crosson C., Ma J.X.;
RT   "Identification and characterization of a novel gene induced by
RT   ischemic preconditioning in the retina.";
RL   Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: GABARAPL1 (GABARAPL2 or GABARAP or MAP1LC3)-modifier
CC       protein conjugating enzyme involved in its E2-like covalent
CC       binding to PE. ATG7 (E1-like enzyme) facilitates this reaction by
CC       forming an E1-E2 complex with ATG3 (E2-like enzyme). Preferred
CC       substrate is MAP1LC3A. Formation of the GABARAPL1-PE conjugate is
CC       essential for autophagy (By similarity).
CC   -!- SUBUNIT: Interacts with ATG7 and ATG12. The complex, composed of
CC       ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the ATG3 family.
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DR   EMBL; AF175224; AAG09182.1; -; mRNA.
DR   EMBL; BC078743; AAH78743.1; -; mRNA.
DR   RefSeq; NP_599221.1; -.
DR   UniGene; Rn.3084; -.
DR   Ensembl; ENSRNOG00000002094; Rattus norvegicus.
DR   GeneID; 171415; -.
DR   KEGG; rno:171415; -.
DR   RGD; 708464; Atg3.
DR   HOVERGEN; Q6AZ50; -.
DR   ArrayExpress; Q6AZ50; -.
DR   GermOnline; ENSRNOG00000002094; Rattus norvegicus.
DR   InterPro; IPR007135; Autophagy_C.
DR   InterPro; IPR007134; Autophagy_N.
DR   Pfam; PF03987; Autophagy_C; 1.
DR   Pfam; PF03986; Autophagy_N; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Cytoplasm; Phosphoprotein; Protein transport; Transport;
KW   Ubl conjugation pathway.
FT   CHAIN         1    314       Autophagy-related protein 3.
FT                                /FTId=PRO_0000213571.
FT   ACT_SITE    264    264       Glycyl thioester intermediate
FT                                (Potential).
FT   MOD_RES      18     18       Phosphotyrosine (By similarity).
FT   CONFLICT    257    257       P -> L (in Ref. 1; AAG09182).
SQ   SEQUENCE   314 AA;  35822 MW;  4C78AB0F628C9BDF CRC64;
     MQNVINTVKG KALEVAEYLT PVLKESKFKE TGVITPEEFV AAGDHLVHHC PTWQWATGEE
     LKVKAYLPTG KQFLVTKNVP CYKRCKQMEY SDELEAIIEE DDGDGGWVDT YHNTGITGIT
     EAVKEITLES KDSIKLQDCS VLCDEEEEEE EGEAADMEEY EESGLLETDE ATLDTRRIVE
     ACKAKADAGG EDAILQTRTY DLYITYDKYY QTPRLWLFGY DEQRQPLTVE HMYEDISQDH
     VKKTVTIENH PHLPPPPMCS VHPCRHAEVM KKIIETVAEG GGELGVHMYL LIFLKFVQAV
     IPTIEYDYTR HFTM
//