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UniProtKB/Swiss-Prot entry Q674R7


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ATG9B_HUMAN
Primary accession number Q674R7
Secondary accession numbers A1A5D3 Q6JRW5 Q8N8I8
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on October 11, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 33)
Name and origin of the protein
Protein name Autophagy-related protein 9B
Synonyms APG9-like 2
Nitric oxide synthase 3-overlapping antisense gene protein
Protein sONE
Gene name
Name: ATG9B
Synonyms: APG9L2, NOS3AS
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
TISSUE=Testis;
DOI=10.1074/jbc.M400271200; PubMed=15234981 [NCBI, ExPASy, EBI, Israel, Japan]
Robb G.B., Carson A.R., Tai S.C., Fish J.E., Singh S., Yamada T., Scherer S.W., Nakabayashi K., Marsden P.A.;
"Post-transcriptional regulation of endothelial nitric-oxide synthase by an overlapping antisense mRNA transcript.";
J. Biol. Chem. 279:37982-37996(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
TISSUE=Placenta;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
INDUCTION.
DOI=10.1074/jbc.M608318200; PubMed=17403686 [NCBI, ExPASy, EBI, Israel, Japan]
Fish J.E., Matouk C.C., Yeboah E., Bevan S.C., Khan M., Patil K., Ohh M., Marsden P.A.;
"Hypoxia-inducible expression of a natural cis-antisense transcript inhibits endothelial nitric-oxide synthase.";
J. Biol. Chem. 282:15652-15666(2007).
Comments
  • FUNCTION: Plays a role in autophagy (By similarity).
  • SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein (By similarity).
  • ALTERNATIVE PRODUCTS: 3 named isoforms [FASTA] produced by alternative splicing.
    Name1
    Isoform IDQ674R7-1
    This is the isoform sequence displayed in this entry.
    Name2
    Isoform IDQ674R7-2
    Note: No experimental confirmation available.
    Features which should be applied to build the isoform sequence: VSP_030410, VSP_030413.
    Name3
    Isoform IDQ674R7-3
    Note: No experimental confirmation available.
    Features which should be applied to build the isoform sequence: VSP_030411, VSP_030412.
  • TISSUE SPECIFICITY: Highly expressed in placenta (trophoblast cells) and pituitary gland. Not expressed in vascular endothelial.
  • INDUCTION: By hypoxia, leading to inhibit NOS3 expression.
  • MISCELLANEOUS: ATG9B gene is located on the opposite DNA strand of the NOS3 gene at chromosome 7q36. The genes are oriented in a tail-to-tail configuration and the mRNAs encoding ATG9B and NOS3 are complementary for 662 nucleotides. ATG9B transcription may a role in NOS3 transcription regulation.
  • SIMILARITY: Belongs to the ATG9 family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY515311; AAS87212.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY316116; AAQ86941.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK096734; BAC04853.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC128587; AAI28588.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BK004019; DAA05200.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_775952.3; -.
UniGene Hs.647092
3D structure databases
ModBase Q674R7.
Organism-specific databases
HGNC HGNC:21899; ATG9B.
GenAtlas ATG9B.
PharmGKB PA134883165; -.
GeneCards Q674R7.
Gene expression databases
ArrayExpress Q674R7; -.
CleanEx HS_ATG9B; -.
Ontologies
GO
GO:0000045; Biological process: autophagosome formation (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR007241; Autophagy_prot_9.
Graphical view of domain structure.
PANTHER PTHR13038; APG9; 1.
Pfam PF04109; APG9; 1.
Pfam graphical view of domain structure.
BLOCKS Q674R7.
Genome annotation databases
Ensembl ENSG00000181652; Homo sapiens. [Contig view]
GeneID 285973; -.
KEGG hsa:285973; -.
Phylogenomic databases
HOGENOM Q674R7; -.
HOVERGEN Q674R7; -.
Other
ProtoNet Q674R7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Autophagy; Cytoplasmic vesicle; Membrane; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   924  924     Autophagy-related protein 9B. PRO_0000314867
TOPO_DOM   1   207  207     Cytoplasmic (By similarity). 
TRANSMEM   208   228  21     Potential. 
TOPO_DOM   229   276  48     Lumenal (By similarity). 
TRANSMEM   277   297  21     Potential. 
TOPO_DOM   298   438  141     Cytoplasmic (By similarity). 
TRANSMEM   439   459  21     Potential. 
TOPO_DOM   460   526  67     Lumenal (By similarity). 
TRANSMEM   527   547  21     Potential. 
TOPO_DOM   548   551  4     Cytoplasmic (By similarity). 
TRANSMEM   552   572  21     Potential. 
TOPO_DOM   573   624  52     Lumenal (By similarity). 
TRANSMEM   625   645  21     Potential. 
TOPO_DOM   646   924  279     Cytoplasmic (By similarity). 
COMPBIAS   22   147  126     Pro-rich. 
VAR_SEQ   1   514        Missing (in isoform 2). VSP_030410
VAR_SEQ   322   340        EELSSVPWAEVQSRLLALQ -> GKGREDTGMYWRGQPGGLD (in isoform 3). VSP_030411
VAR_SEQ   341   924        Missing (in isoform 3). VSP_030412
VAR_SEQ   515   572        RTAAPPAPLRTLLARQLVFFAGALFAALLVLTVYDEDVLA VEHVLTAMTALGVTATVA -> MPSYPQPSVLRGSAPARCWSSSWSWLPASGWSNCFAQSAT SSATGTSRCFTGRPCTSP (in isoform 2). VSP_030413
CONFLICT   12    12        R -> K (in Ref. 2; BAC04853). 
CONFLICT   751   751        S -> P (in Ref. 1; AAQ86941). 
CONFLICT   752   752        T -> P (in Ref. 1; AAQ86941). 
CONFLICT   760   760        T -> A (in Ref. 1; AAQ86941). 
Sequence information
Length: 924 AA [This is the length of the unprocessed precursor] Molecular weight: 101019 Da [This is the MW of the unprocessed precursor] CRC64: 80C242069DF3D91E [This is a checksum on the sequence]
        10         20         30         40         50         60 
MVSRMGWGGR RRRLGRWGDL GPGSVPLLPM PLPPPPPPSC RGPGGGRISI FSLSPAPHTR 

        70         80         90        100        110        120 
SSPSSFSPPT AGPPCSVLQG TGASQSCHSA LPIPATPPTQ AQPAMTPASA SPSWGSHSTP 

       130        140        150        160        170        180 
PLAPATPTPS QQCPQDSPGL RVGPLIPEQD YERLEDCDPE GSQDSPIHGE EQQPLLHVPE 

       190        200        210        220        230        240 
GLRGSWHHIQ NLDSFFTKIY SYHQRNGFAC ILLEDVFQLG QFIFIVTFTT FLLRCVDYNV 

       250        260        270        280        290        300 
LFANQPSNHT RPGPFHSKVT LSDAILPSAQ CAERIRSSPL LVLLLVLAAG FWLVQLLRSV 

       310        320        330        340        350        360 
CNLFSYWDIQ VFYREALHIP PEELSSVPWA EVQSRLLALQ RSGGLCVQPR PLTELDIHHR 

       370        380        390        400        410        420 
ILRYTNYQVA LANKGLLPAR CPLPWGGSAA FLSRGLALNV DLLLFRGPFS LFRGGWELPH 

       430        440        450        460        470        480 
AYKRSDQRGA LAARWGRTVL LLAALNLALS PLVLAWQVLH VFYSHVELLR REPGALGARG 

       490        500        510        520        530        540 
WSRLARLQLR HFNELPHELR ARLARAYRPA AAFLRTAAPP APLRTLLARQ LVFFAGALFA 

       550        560        570        580        590        600 
ALLVLTVYDE DVLAVEHVLT AMTALGVTAT VARSFIPEEQ CQGRAPQLLL QTALAHMHYL 

       610        620        630        640        650        660 
PEEPGPGGRD RAYRQMAQLL QYRAVSLLEE LLSPLLTPLF LLFWFRPRAL EIIDFFHHFT 

       670        680        690        700        710        720 
VDVAGVGDIC SFALMDVKRH GHPQWLSAGQ TEASLSQRAE DGKTELSLMR FSLAHPLWRP 

       730        740        750        760        770        780 
PGHSSKFLGH LWGRVQQDAA AWGATSARGP STPGVLSNCT SPLPEAFLAN LFVHPLLPPR 

       790        800        810        820        830        840 
DLSPTAPCPA AATASLLASI SRIAQDPSSV SPGGTGGQKL AQLPELASAE MSLHVIYLHQ 

       850        860        870        880        890        900 
LHQQQQQQEP WGEAAASILS RPCSSPSQPP SPDEEKPSWS SDGSSPASSP RQQWGTQKAR 

       910        920 
NLFPGGFQVT TDTQKEPDRA SCTD 

Q674R7 in FASTA format

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