[1]	NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING. TISSUE=Cerebellum; PubMed=1846020 [NCBI, ExPASy, EBI, Israel, Japan] Middlemas D.S., Lindberg R.A., Hunter T.; "trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors."; Mol. Cell. Biol. 11:143-153(1991).
[2]	PHOSPHORYLATION AT TYR-701; TYR-705; TYR-706 AND TYR-816. PubMed=8106527 [NCBI, ExPASy, EBI, Israel, Japan] Middlemas D.S., Meisenhelder J., Hunter T.; "Identification of TrkB autophosphorylation sites and evidence that phospholipase C-gamma 1 is a substrate of the TrkB receptor."; J. Biol. Chem. 269:5458-5466(1994).
[3]	INTERACTION WITH SH2B2. DOI=10.1016/S0896-6273(00)80620-0; PubMed=9856458 [NCBI, ExPASy, EBI, Israel, Japan] Qian X., Riccio A., Zhang Y., Ginty D.D.; "Identification and characterization of novel substrates of Trk receptors in developing neurons."; Neuron 21:1017-1029(1998).
[4]	INTERACTION WITH SQSTM1. DOI=10.1074/jbc.M208468200; PubMed=12471037 [NCBI, ExPASy, EBI, Israel, Japan] Geetha T., Wooten M.W.; "Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling."; J. Biol. Chem. 278:4730-4739(2003).
[5]	INTERACTION WITH ARMS. DOI=10.1038/sj.emboj.7600253; PubMed=15167895 [NCBI, ExPASy, EBI, Israel, Japan] Arevalo J.C., Yano H., Teng K.K., Chao M.V.; "A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein."; EMBO J. 23:2358-2368(2004).

Comments

FUNCTION: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Binds SH2B2. Interacts with SQSTM1 and ARMS.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

ALTERNATIVE PRODUCTS: 3 named isoforms [FASTA] produced by alternative splicing. Additional isoforms seem to exist.

Name	GP145-TrkB
Isoform ID	Q63604-1
This is the isoform sequence displayed in this entry.

Name	T1
Synonyms	GP95-TrkB
Isoform ID	Q63604-2
Features which should be applied to build the isoform sequence: VSP_002910, VSP_002911.

Name	T2
Isoform ID	Q63604-3
Features which should be applied to build the isoform sequence: VSP_002912, VSP_002913.

TISSUE SPECIFICITY: The different forms are differentially expressed in various cell types. Isoform T2 is primarily expressed in neurons.
PTM: Ligand-mediated auto-phosphorylation.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
SIMILARITY: Contains 2 LRR (leucine-rich) repeats.
SIMILARITY: Contains 1 protein kinase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M55291; AAA42279.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M55292; AAA42280.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M55293; AAA42281.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A39667; A39667.
B39667; B39667.
C39667; C39667.

RefSeq

NP_036863.1; -.

UniGene

Rn.11246

3D structure databases

HSSP

Q16620; 1WWB. [HSSP ENTRY / PDB]

SMR

Q63604; 283-385.

ModBase

Q63604.

Protein-protein interaction databases

DIP

DIP:5717N; -.

PTM databases

PhosphoSite

Q63604; -.

Organism-specific databases

RGD

3213; Ntrk2.

Gene expression databases

ArrayExpress

Q63604; -.

GermOnline

ENSRNOG00000018839; Rattus norvegicus.

Ontologies

GO:0000139;	Cellular component: Golgi membrane (inferred from experiment from Reactome).
GO:0005886;	Cellular component: plasma membrane (inferred from experiment from Reactome).
QuickGo view.

Family and domain databases

InterPro

IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR000483; LRR_C.
IPR000372; LRR_cys_N.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR002011; Recept_tyr_kinase-II_CS.
IPR001245; Tyr_pkinase.
IPR008266; Tyr_pkinase_AS.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.40.10; Ig-like_fold; 2.

Pfam

PF07679; I-set; 1.
PF01462; LRRNT; 1.
PF07714; Pkinase_Tyr; 1.
Pfam graphical view of domain structure.

PRINTS

PR00109; TYRKINASE.

ProDom

PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00408; IGc2; 1.
SM00082; LRRCT; 1.
SM00013; LRRNT; 1.
SM00219; TyrKc; 1.
SMART graphical view of domain structure.

PROSITE

PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q63604.

Genome annotation databases

Ensembl

ENSRNOG00000018839; Rattus norvegicus. [Contig view]

GeneID

25054; -.

KEGG

rno:25054; -.

Phylogenomic databases

HOVERGEN

Q63604; -.

Other

ProtoNet

Q63604.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; ATP-binding; Developmental protein; Differentiation; Glycoprotein; Immunoglobulin domain; Kinase; Leucine-rich repeat; Membrane; Neurogenesis; Nucleotide-binding; Phosphoprotein; Receptor; Repeat; Signal; Transferase; Transmembrane; Tyrosine-protein kinase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 31`	`31`	`By similarity.`
`CHAIN`	`32 821`	`790`	`BDNF/NT-3 growth factors receptor.`	`PRO_0000016729`
`TOPO_DOM`	`32 429`	`398`	`Extracellular (Potential).`
`TRANSMEM`	`430 453`	`24`	`Potential.`
`TOPO_DOM`	`454 821`	`368`	`Cytoplasmic (Potential).`
`REPEAT`	`72 93`	`22`	`LRR 1.`
`REPEAT`	`96 117`	`22`	`LRR 2.`
`DOMAIN`	`197 282`	`86`	`Ig-like C2-type 1.`
`DOMAIN`	`295 365`	`71`	`Ig-like C2-type 2.`
`DOMAIN`	`537 806`	`270`	`Protein kinase.`
`NP_BIND`	`543 551`	`9`	`ATP (By similarity).`
`ACT_SITE`	`675 675`		`Proton acceptor (By similarity).`
`BINDING`	`571 571`		`ATP (By similarity).`
`SITE`	`515 515`	`1`	`Interaction with SHC1 (By similarity).`
`SITE`	`816 816`	`1`	`Interaction with PLC-gamma-1 (By similarity).`
`MOD_RES`	`515 515`		`Phosphotyrosine; by autocatalysis (By similarity).`
`MOD_RES`	`701 701`		`Phosphotyrosine; by autocatalysis.`
`MOD_RES`	`705 705`		`Phosphotyrosine; by autocatalysis.`
`MOD_RES`	`706 706`		`Phosphotyrosine; by autocatalysis.`
`MOD_RES`	`816 816`		`Phosphotyrosine; by autocatalysis.`
`CARBOHYD`	`67 67`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`95 95`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`121 121`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`178 178`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`205 205`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`241 241`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`254 254`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`280 280`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`325 325`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`338 338`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`411 411`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`32 38`		`By similarity.`
`DISULFID`	`36 45`		`By similarity.`
`DISULFID`	`152 176`		`By similarity.`
`DISULFID`	`154 194`		`By similarity.`
`DISULFID`	`218 266`		`By similarity.`
`DISULFID`	`302 345`		`By similarity.`
`VAR_SEQ`	`466 476`		`PASVISNDDDS -> FVLFHKIPLDG (in isoform T1).`	`VSP_002910`
`VAR_SEQ`	`466 474`		`PASVISNDD -> KQKCAYFAS (in isoform T2).`	`VSP_002912`
`VAR_SEQ`	`475 821`		`Missing (in isoform T2).`	`VSP_002913`
`VAR_SEQ`	`477 821`		`Missing (in isoform T1).`	`VSP_002911`

Sequence information

Length: 821 AA [This is the length of the unprocessed precursor]

Molecular weight: 92186 Da [This is the MW of the unprocessed precursor]

CRC64: 0DDACDA212CDAA0E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSPWPRWHGP AMARLWGLCL LVLGFWRASL ACPMSCKCST TRIWCTEPSP GIVAFPRLEP 

        70         80         90        100        110        120 
NSIDPENITE ILIANQKRLE IINEDDVEAY VGLKNLTIVD SGLKFVAYKA FLKNGNLRHI 

       130        140        150        160        170        180 
NFTRNKLTSL SRRHFRHLDL SDLILTGNPF TCSCDIMWLK TLQETKSSPD TQDLYCLNES 

       190        200        210        220        230        240 
SKNTPLANLQ IPNCGLPSAR LAAPNLTVEE GKSVTISCSV GGDPLPTLYW DVGNLVSKHM 

       250        260        270        280        290        300 
NETSHTQGSL RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH 

       310        320        330        340        350        360 
WCIPFTVRGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN PTHMNNGDYT 

       370        380        390        400        410        420 
LMAKNEYGKD ERQISAHFMG RPGVDYETNP NYPEVLYEDW TTPTDIGDTT NKSNEIPSTD 

       430        440        450        460        470        480 
VADQTNREHL SVYAVVVIAS VVGFCLLVML LLLKLARHSK FGMKGPASVI SNDDDSASPL 

       490        500        510        520        530        540 
HHISNGSNTP SSSEGGPDAV IIGMTKIPVI ENPQYFGITN SQLKPDTFVQ HIKRHNIVLK 

       550        560        570        580        590        600 
RELGEGAFGK VFLAECYNLC PEQDKILVAV KTLKDASDNA RKDFHREAEL LTNLQHEHIV 

       610        620        630        640        650        660 
KFYGVCVEGD PLIMVFEYMK HGDLNKFLRA HGPDAVLMAE GNPPTELTQS QMLHIAQQIA 

       670        680        690        700        710        720 
AGMVYLASQH FVHRDLATRN CLVGENLLVK IGDFGMSRDV YSTDYYRVGG HTMLPIRWMP 

       730        740        750        760        770        780 
PESIMYRKFT TESDVWSLGV VLWEIFTYGK QPWYQLSNNE VIECITQGRV LQRPRTCPQE 

       790        800        810        820 
VYELMLGCWQ REPHTRKNIK NIHTLLQNLA KASPVYLDIL G

Q63604 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools