[1]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS IIA AND IIB). TISSUE=Brain; DOI=10.1126/science.2506642; PubMed=2506642 [NCBI, ExPASy, EBI, Israel, Japan] Suedhof T.C., Czernik A.J., Kao H.-T., Takei K., Johnston P.A., Horiuchi A., Kanazir S.D., Wagner M.A., Perin M.S., de Camilli P., Greengard P.; "Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins."; Science 245:1474-1480(1989).
[2]	PROTEIN SEQUENCE OF 136-143; 178-200; 245-257; 405-414 AND 544-560, AND MASS SPECTROMETRY. STRAIN=Sprague-Dawley; TISSUE=Hippocampus; Lubec G., Chen W.-Q.; Submitted (APR-2007) to UniProtKB.
[3]	INTERACTION WITH CAPON. DOI=10.1073/pnas.261705799; PubMed=11867766 [NCBI, ExPASy, EBI, Israel, Japan] Jaffrey S.R., Benfenati F., Snowman A.M., Czernik A.J., Snyder S.H.; "Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON."; Proc. Natl. Acad. Sci. U.S.A. 99:3199-3204(2002).

Comments

FUNCTION: Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release (By similarity).
SUBUNIT: Interacts with CAPON.
SUBCELLULAR LOCATION: Cell junction, synapse.
ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing.

Name IIa

Isoform ID Q63537-1

This is the isoform sequence displayed in this entry.

Name IIb

Isoform ID Q63537-2

Features which should be applied to build the isoform sequence: VSP_006322, VSP_006323.
SIMILARITY: Belongs to the synapsin family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M27925; AAA42100.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M27926; AAA42101.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00210036; -.
IPI00231408; -.

PIR

C30411; C30411.

RefSeq

NP_001029192.1; -.
NP_062032.1; -.

UniGene

Rn.506

3D structure databases

PDB

1I7L; X-ray; 2.35 A; A/B=113-421.	[ExPASy / RCSB / EBI]
1I7N; X-ray; 1.90 A; A/B=113-421.	[ExPASy / RCSB / EBI]

Detailed list of linked structures.

1I7L; -.
1I7N; -.

PTM databases

Q63537; -.

Organism-specific databases

RGD

3798; Syn2.

Gene expression databases

ArrayExpress

Q63537; -.

GermOnline

ENSRNOG00000008157; Rattus norvegicus.

Ontologies

GO:0030054;	Cellular component: cell junction (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005524;	Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0003824;	Molecular function: catalytic activity (inferred from electronic annotation from InterPro).
GO:0008092;	Molecular function: cytoskeletal protein binding (traceable author statement from RGD).
GO:0007269;	Biological process: neurotransmitter secretion (inferred from electronic annotation from InterPro).
GO:0046928;	Biological process: regulation of neurotransmitter secretion (traceable author statement from RGD).
QuickGo view.

Family and domain databases

InterPro

IPR013816; ATP_grasp_subdomain_2.
IPR001359; Synapsin.
IPR019735; Synapsin_CS.
IPR019569; Synapsin_N.
IPR019736; Synapsin_phosporylation.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.

Pfam

PF02078; Synapsin; 1.
PF02750; Synapsin_C; 1.
PF10581; Synapsin_N; 1.
Pfam graphical view of domain structure.

PRINTS

PR01368; SYNAPSIN.

PROSITE

PS00415; SYNAPSIN_1; 1.
PS00416; SYNAPSIN_2; 1.

Proteomic databases

PRIDE

Q63537; -.

Genome annotation databases

Ensembl

ENSRNOG00000008157; Rattus norvegicus. [Contig view]

GeneID

29179; -.

KEGG

rno:29179; -.

Phylogenomic databases

HOVERGEN

Q63537; -.

Other

608259; -.

Q63537; -.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

3D-structure; Alternative splicing; Cell junction; Direct protein sequencing; Phosphoprotein; Synapse.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 586`	`586`	`Synapsin-2.`	`PRO_0000183023`
`REGION`	`1 29`	`29`	`A.`
`REGION`	`33 113`	`81`	`B; linker.`
`REGION`	`114 421`	`308`	`C; actin-binding and synaptic-vesicle binding.`
`REGION`	`422 458`	`37`	`G; Pro-rich linker.`
`REGION`	`459 537`	`79`	`H; Pro/Ser-rich linker.`
`REGION`	`538 586`	`49`	`E.`
`COMPBIAS`	`487 499`	`13`	`Poly-Ser.`
`COMPBIAS`	`515 520`	`6`	`Poly-Ser.`
`MOD_RES`	`422 422`		`Phosphothreonine (By similarity).`
`MOD_RES`	`426 426`		`Phosphoserine (By similarity).`
`VAR_SEQ`	`459 479`		`GPGQPQGMQPPGKVLPPRRLP -> CLQYILNCNGIAVGPKQVQAS (in isoform IIb).`	`VSP_006322`
`VAR_SEQ`	`480 586`		`Missing (in isoform IIb).`	`VSP_006323`
`STRAND`	`114 120`	`7`
`HELIX`	`127 131`	`5`
`TURN`	`137 139`	`3`
`STRAND`	`140 147`	`8`
`HELIX`	`149 151`	`3`
`STRAND`	`152 157`	`6`
`STRAND`	`162 169`	`8`
`STRAND`	`171 173`	`3`
`STRAND`	`175 179`	`5`
`STRAND`	`182 186`	`5`
`HELIX`	`200 208`	`9`
`STRAND`	`213 215`	`3`
`HELIX`	`217 222`	`6`
`HELIX`	`226 240`	`15`
`TURN`	`242 244`	`3`
`STRAND`	`251 255`	`5`
`HELIX`	`256 260`	`5`
`STRAND`	`265 273`	`9`
`TURN`	`276 279`	`4`
`STRAND`	`280 283`	`4`
`HELIX`	`288 299`	`12`
`STRAND`	`303 307`	`5`
`STRAND`	`311 320`	`10`
`STRAND`	`323 333`	`11`
`STRAND`	`340 348`	`9`
`HELIX`	`352 361`	`10`
`HELIX`	`362 366`	`5`
`STRAND`	`369 378`	`10`
`STRAND`	`383 389`	`7`
`HELIX`	`400 418`	`19`

Sequence information

Length: 586 AA [This is the length of the unprocessed precursor]

Molecular weight: 63457 Da [This is the MW of the unprocessed precursor]

CRC64: 630B7071B2F38857 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MMNFLRRRLS DSSFIANLPN GYMTDLQRPE PQQPPPAPGP GTATASAATS AASPGPERRP 

        70         80         90        100        110        120 
PPAQAPAPQP APQPAPTPSV GSSFFSSLSQ AVKQTAASAG LVDAPAPSAA SRKAKVLLVV 

       130        140        150        160        170        180 
DEPHTDWAKC FRGKKILGDY DIKVEQAEFS ELNLVAHADG TYAVDMQVLR NGTKVVRSFR 

       190        200        210        220        230        240 
PDFVLIRQHA FGMAENEDFR HLVIGMQYAG LPSINSLESI YNFCDKPWVF AQMVAIFKTL 

       250        260        270        280        290        300 
GGEKFPLIEQ TYYPNHREML TLPTFPVVVK IGHAHSGMGK VKVENHYDFQ DIASVVALTQ 

       310        320        330        340        350        360 
TYATAEPFID AKYDIRVQKI GNNYKAYMRT SISGNWKTNT GSAMLEQIAM SDRYKLWVDA 

       370        380        390        400        410        420 
CSEMFGGLDI CAVKAVHGKD GKDYIFEVMD CSMPLIGEHQ VEDRQLITDL VISKMNQLLS 

       430        440        450        460        470        480 
RTPALSPQRP LTTQQPQSGT LKEPDSSKTP PQRPAPQGGP GQPQGMQPPG KVLPPRRLPS 

       490        500        510        520        530        540 
GPSLPPSSSS SSSSSSSSSA PQRPGGPTST QVNASSSSNS LAEPQAPQAA PPQKPQPHPQ 

       550        560        570        580 
LNKSQSLTNA FSFSESSFFR SSANEDEAKA ETIRSLRKSF ASLFSD

Q63537 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools