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[1]
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NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
TISSUE=Hippocampus;
DOI=10.1016/0896-6273(95)90299-6; PubMed=7857651 [NCBI, ExPASy, EBI, Israel, Japan]
Lyford G.L.,
Yamagata K.,
Kaufmann W.E.,
Barnes C.A.,
Sanders L.K.,
Copeland N.G.,
Gilbert D.J.,
Jenkins N.A.,
Lanahan A.A.,
Worley P.F.;
"Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites.";
Neuron 14:433-445(1995).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
STRAIN=Sprague-Dawley;
TISSUE=Hippocampus;
PubMed=7777577 [NCBI, ExPASy, EBI, Israel, Japan]
Link W.,
Konietzko U.,
Kauselmann G.,
Krug M.,
Schwanke B.,
Frey U.,
Kuhl D.;
"Somatodendritic expression of an immediate early gene is regulated by synaptic activity.";
Proc. Natl. Acad. Sci. U.S.A. 92:5734-5738(1995).
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[3]
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SUBCELLULAR LOCATION, AND INTERACTION WITH DNM2; SH3GL1 AND SH3GL3.
DOI=10.1016/j.neuron.2006.08.033; PubMed=17088211 [NCBI, ExPASy, EBI, Israel, Japan]
Chowdhury S.,
Shepherd J.D.,
Okuno H.,
Lyford G.,
Petralia R.S.,
Plath N.,
Kuhl D.,
Huganir R.L.,
Worley P.F.;
"Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking.";
Neuron 52:445-459(2006).
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[4]
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FUNCTION.
DOI=10.1016/j.neuron.2006.09.031; PubMed=17088212 [NCBI, ExPASy, EBI, Israel, Japan]
Rial Verde E.M.,
Lee-Osbourne J.,
Worley P.F.,
Malinow R.,
Cline H.T.;
"Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission.";
Neuron 52:461-474(2006).
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[5]
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FUNCTION.
DOI=10.1016/j.neuron.2006.08.034; PubMed=17088213 [NCBI, ExPASy, EBI, Israel, Japan]
Shepherd J.D.,
Rumbaugh G.,
Wu J.,
Chowdhury S.,
Plath N.,
Kuhl D.,
Huganir R.L.,
Worley P.F.;
"Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA Receptors.";
Neuron 52:475-484(2006).
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- FUNCTION: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.
- SUBUNIT: Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2.
- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Endosome. Acrosome (By similarity). Cytoplasm, cell cortex. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail.
- TISSUE SPECIFICITY: Expressed exclusively in certain parts of the brain including cortex and molecular layer of the hippocampus. Typically expressed at high level in a minority of neurons. Basal expression higher in cortex than in hippocampus, highest in visual cortex.
- DEVELOPMENTAL STAGE: Expressed during postnatal development from day 8. Highest expression around day 23 with moderate levels expressed to adulthood.
- INDUCTION: By synaptic activity in hippocampus, cerebral cortex, amygdala and hypothalamus. Highest level in hippocampus within 30 min, dropping to basal levels within 24 hours. By NGF and EGF in fibroblasts.
- MISCELLANEOUS: Widely used as activity-dependent neuronal marker to identify recently activated neurons in behavioral studies (By similarity).
- MISCELLANEOUS: Neurons overexpressing Arc show reduced AMPA receptor-dependent synaptic transmission associated with reduced surface levels of AMPA receptor. This effect is dependent on NMDA receptor activity.
- MISCELLANEOUS: Transcripts enriched in dendrites may be translated locally.
- SIMILARITY: Belongs to the ARC/ARG3.1 family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 396 AA [This is the length of the unprocessed precursor] |
Molecular weight: 45353 Da [This is the MW of the unprocessed precursor] |
CRC64: 4E95B46B75853CA5 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MELDHMTTGG LHAYPAPRGG PAAKPNVILQ IGKCRAEMLE HVRRTHRHLL TEVSKQVERE
70 80 90 100 110 120
LKGLHRSVGK LENNLDGYVP TGDSQRWKKS IKACLCRCQE TIANLERWVK REMHVWREVF
130 140 150 160 170 180
YRLERWADRL ESMGGKYPVG SEPARHTVSV GVGGPEPYCQ EADGYDYTVS PYAITPPPAA
190 200 210 220 230 240
GELPEQESVG AQQYQSWVPG EDGQPSPGVD TQIFEDPREF LSHLEEYLRQ VGGSEEYWLS
250 260 270 280 290 300
QIQNHMNGPA KKWWEFKQGS VKNWVEFKKE FLQYSEGTLS REAIQRELDL PQKQGEPLDQ
310 320 330 340 350 360
FLWRKRDLYQ TLYVDAEEEE IIQYVVGTLQ PKFKRFLRHP LPKTLEQLIQ RGMEVQDGLE
370 380 390
QAAEPSVTPL PTEDETEALT PALTSESVAS DRTQPE
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Q63053 in FASTA format |
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