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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
DOI=10.1073/pnas.93.16.8677; PubMed=8710930 [NCBI, ExPASy, EBI, Israel, Japan]
Nothacker H.-P.,
Reinscheid R.K.,
Mansour A.,
Henningsen R.A.,
Ardati A.,
Monsma F.J. Jr.,
Watson S.J.,
Civelli O.;
"Primary structure and tissue distribution of the orphanin FQ precursor.";
Proc. Natl. Acad. Sci. U.S.A. 93:8677-8682(1996).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1073/pnas.93.16.8666; PubMed=8710928 [NCBI, ExPASy, EBI, Israel, Japan]
Mollereau C.,
Simons M.-J.,
Soularue P.,
Liners F.,
Vassart G.,
Meunier J.-C.,
Parmentier M.;
"Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene.";
Proc. Natl. Acad. Sci. U.S.A. 93:8666-8670(1996).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] OF 13-181, AND PROTEIN SEQUENCE OF 135-151.
TISSUE=Brain;
DOI=10.1038/377532a0; PubMed=7566152 [NCBI, ExPASy, EBI, Israel, Japan]
Meunier J.-C.,
Mollereau C.,
Toll L.,
Suaudeau C.,
Moisand C.,
Alvinerie P.,
Butour J.-L.,
Guillemot J.-C.,
Ferrara P.,
Monsarrat B.,
Mazarguil H.,
Vassart G.,
Parmentier M.,
Costentin J.;
"Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor.";
Nature 377:532-535(1995).
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- FUNCTION: Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.
- SUBCELLULAR LOCATION: Secreted.
- TISSUE SPECIFICITY: Expressed predominantly in the spinal cord and brain, being more abundant in the hypothalamus and striatum. Also found in small amounts in ovary.
- PTM: Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.
- PTM: The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
- SIMILARITY: Belongs to the opioid neuropeptide precursor family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 181 AA [This is the length of the unprocessed precursor] |
Molecular weight: 20479 Da [This is the MW of the unprocessed precursor] |
CRC64: B2E9119CF8702C37 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MKILFCDVLL LSLLSSVFSS CPEDCLTCQE RLHPAPGSFN LKLCILQCEE KVFPRPLWTL
70 80 90 100 110 120
CTKAMASDSE QLSPADPELT SAALYQSKAS EMQHLKRMPR VRSVVQARDA EPEADAEPVA
130 140 150 160 170 180
DEADEVEQKQ LQKRFGGFTG ARKSARKLAN QKRFSEFMRQ YLVLSMQSSQ RRRTLHQNGN
V
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Q62923 in FASTA format |
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