ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q61143

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name TRPC6_MOUSE
Primary accession number Q61143
Secondary accession number Q9Z2J1
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on June 1, 1998 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 83)
Name and origin of the protein
Protein name Short transient receptor potential channel 6
Synonyms TrpC6
Calcium entry channel
Gene name
Name: Trpc6
Synonyms: Trp6, Trrp6
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
DOI=10.1074/jbc.272.47.29672; PubMed=9368034 [NCBI, ExPASy, EBI, Israel, Japan]
Boulay G., Zhu X., Peyton M., Jiang M., Hurst R., Stefani E., Birnbaumer L.;
"Cloning and expression of a novel mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the Gq class of G protein.";
J. Biol. Chem. 272:29672-29680(1997).
[2]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=DBA/2;
DOI=10.1038/sj.onc.1202445; PubMed=10050885 [NCBI, ExPASy, EBI, Israel, Japan]
Buess M., Engler O., Hirsch H.H., Moroni C.;
"Search for oncogenic regulators in an autocrine tumor model using differential display PCR: identification of novel candidate genes including the calcium channel mtrp6.";
Oncogene 18:1487-1494(1999).
[3]
 NUCLEOTIDE SEQUENCE [MRNA] OF 631-739.
TISSUE=Brain;
DOI=10.1016/S0092-8674(00)81233-7; PubMed=8646775 [NCBI, ExPASy, EBI, Israel, Japan]
Zhu X., Jiang M., Peyton M., Boulay G., Hurst R., Stefani E., Birnbaumer L.;
"trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry.";
Cell 85:661-671(1996).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U49069; AAC06146.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF057748; AAC64394.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00117824; -.
UniGene Mm.325086
3D structure databases
ModBase Q61143.
PTM databases
PhosphoSite Q61143; -.
Organism-specific databases
MGI MGI:109523; Trpc6.
Gene expression databases
ArrayExpress Q61143; -.
Bgee Q61143; -.
GermOnline ENSMUSG00000031997; Mus musculus.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005509; Molecular function: calcium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0015279; Molecular function: store-operated calcium channel activity (inferred from direct assay from MGI).
GO:0006816; Biological process: calcium ion transport (inferred from electronic annotation from UniProtKB-KW).
GO:0007204; Biological process: elevation of cytosolic calcium ion concentration (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR002110; ANK.
IPR005821; Ion_trans.
IPR002153; Trans_rcpt.
IPR013555; TRP_2.
IPR004729; TRP_channel.
IPR005462; TRP_channel6.
Graphical view of domain structure.
Gene3D G3DSA:1.25.40.20; ANK; 1.
Pfam PF00023; Ank; 3.
PF00520; Ion_trans; 1.
PF08344; TRP_2; 1.
Pfam graphical view of domain structure.
PRINTS PR01097; TRNSRECEPTRP.
PR01647; TRPCHANNEL6.
SMART SM00248; ANK; 3.
SMART graphical view of domain structure.
TIGRFAMs TIGR00870; trp; 1.
PROSITE PS50297; ANK_REP_REGION; 1.
PS50088; ANK_REPEAT; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q61143; -.
Genome annotation databases
Ensembl ENSMUSG00000031997; Mus musculus. [Contig view]
Phylogenomic databases
HOGENOM Q61143; -.
HOVERGEN Q61143; -.
Other
SOURCE Trpc6; Mus musculus.
ProtoNet Q61143.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ANK repeat; Calcium; Calcium channel; Calcium transport; Glycoprotein; Ion transport; Ionic channel; Membrane; Phosphoprotein; Repeat; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   930  930     Short transient receptor potential channel 6. PRO_0000215323
TOPO_DOM   1   437  437     Cytoplasmic (Potential). 
TRANSMEM   438   458  21     Potential. 
TOPO_DOM   459   486  28     Extracellular (Potential). 
TRANSMEM   487   507  21     Potential. 
TOPO_DOM   508   520  13     Cytoplasmic (Potential). 
TRANSMEM   521   541  21     Potential. 
TOPO_DOM   542   591  50     Extracellular (Potential). 
TRANSMEM   592   612  21     Potential. 
TOPO_DOM   613   635  23     Cytoplasmic (Potential). 
TRANSMEM   636   656  21     Potential. 
TOPO_DOM   657   705  49     Extracellular (Potential). 
TRANSMEM   706   726  21     Potential. 
TOPO_DOM   727   930  204     Cytoplasmic (Potential). 
REPEAT   131   160  30     ANK 1. 
REPEAT   162   188  27     ANK 2. 
REPEAT   217   246  30     ANK 3. 
MOD_RES   69    69        Phosphothreonine (By similarity). 
MOD_RES   814   814        Phosphoserine (By similarity). 
MOD_RES   838   838        Phosphoserine (By similarity). 
CARBOHYD   560   560        N-linked (GlcNAc...) (Potential). 
CONFLICT   3    56        Missing (in Ref. 2). 
CONFLICT   105   105        V -> A (in Ref. 2; AAC64394). 
CONFLICT   114   114        W -> R (in Ref. 2; AAC64394). 
CONFLICT   134   134        N -> D (in Ref. 2; AAC64394). 
CONFLICT   184   184        S -> A (in Ref. 2; AAC64394). 
CONFLICT   371   371        D -> Y (in Ref. 2; AAC64394). 
CONFLICT   436   437        PR -> RG (in Ref. 2; AAC64394). 
CONFLICT   905   905        S -> T (in Ref. 2; AAC64394). 
Sequence information
Length: 930 AA [This is the length of the unprocessed precursor] Molecular weight: 106733 Da [This is the MW of the unprocessed precursor] CRC64: CF21A426972732F3 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSQSPRFVTR RGGSLKAAPG AGTRRNESQD YLLMDELGDD GYPQLPLPPY GYYPSFRGNE 

        70         80         90        100        110        120 
NRLTHRRQTI LREKGRRLAN RGPAYMFNDH STSLSIEEER FLDAVEYGNI PVVWKMLEEC 

       130        140        150        160        170        180 
HSLNVNCVDY MGQNALQLAV ANEHLEITEL LLKKENLSRV GDALLLAISK GYVRIVEAIL 

       190        200        210        220        230        240 
NHPSFAEGKR LATSPSQSEL QQDDFYAYDE DGTRFSHDVT PIILAAHCQE YEIVHTLLRK 

       250        260        270        280        290        300 
GARIERPHDY FCKCTECSQK QKHDSFSHSR SRINAYKGLA SPAYLSLSSE DPVMTALELS 

       310        320        330        340        350        360 
NELAVLANIE KEFKNDYRKL SMQCKDFVVG LLDLCRNTEE VEAILNGDAE TRQPGDFGRP 

       370        380        390        400        410        420 
NLSRLKLAIK DEVKKFVAHP NCQQQLLSIW YENLSGLRQQ TMAVKFLVVL AVAIGLPFLA 

       430        440        450        460        470        480 
LIYWCAPCSK MGKILPRPFM KFVAHAASFT IFLGLLVMNA ADRFEGTKLL PNETSTDNAR 

       490        500        510        520        530        540 
QLFRMKTSCF SWMEMLIISW VIGMIWAECK EIWTQGPKEY LFELWNMLDF GMLAIFAASF 

       550        560        570        580        590        600 
IARFMAFWHA SKAQSIIDAN DTLKDLTKVT LGDNVKYYNL ARIKWDPTDP QIISEGLYAI 

       610        620        630        640        650        660 
AVVLSFSRIA YILPANESFG PLQISLGRTV KDIFKFMVIF IMVFVAFMIG MFNLYSYYIG 

       670        680        690        700        710        720 
AKQNEAFTTV EESFKTLFWA IFGLSEVKSV VINYNHKFIE NIGYVLYGVY NVTMVIVLLN 

       730        740        750        760        770        780 
MLIAMINSSF QEIEDDADVE WKFARAKLWF SYFEEGRTLP VPFNLVPSPK SLLYLLLKFK 

       790        800        810        820        830        840 
KWMCELIQGQ KQGFQEDAEM NKRNEEKKFG ISGSHEDLSK FSLDKNQLAH NKQSSTRSSE 

       850        860        870        880        890        900 
DYHLNSFSNP PRQYQKIMKR LIKRYVLQAQ IDKESDEVNE GELKEIKQDI SSLRYELLEE 

       910        920        930 
KSQNSEDLAE LIRKLGERLS LEPKLEESRR
Q61143 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by ca flag CBR Canada Mirror sites: Australia Brazil China Korea Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!