[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Brain; DOI=10.1074/jbc.272.47.29672; PubMed=9368034 [NCBI, ExPASy, EBI, Israel, Japan] Boulay G., Zhu X., Peyton M., Jiang M., Hurst R., Stefani E., Birnbaumer L.; "Cloning and expression of a novel mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the Gq class of G protein."; J. Biol. Chem. 272:29672-29680(1997).
[2]	NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=DBA/2; DOI=10.1038/sj.onc.1202445; PubMed=10050885 [NCBI, ExPASy, EBI, Israel, Japan] Buess M., Engler O., Hirsch H.H., Moroni C.; "Search for oncogenic regulators in an autocrine tumor model using differential display PCR: identification of novel candidate genes including the calcium channel mtrp6."; Oncogene 18:1487-1494(1999).
[3]	NUCLEOTIDE SEQUENCE [MRNA] OF 631-739. TISSUE=Brain; DOI=10.1016/S0092-8674(00)81233-7; PubMed=8646775 [NCBI, ExPASy, EBI, Israel, Japan] Zhu X., Jiang M., Peyton M., Boulay G., Hurst R., Stefani E., Birnbaumer L.; "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry."; Cell 85:661-671(1996).

Comments

FUNCTION: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable).
TISSUE SPECIFICITY: Lung and brain.
PTM: N-glycosylated.
SIMILARITY: Belongs to the transient receptor family. STrpC subfamily.
SIMILARITY: Contains 3 ANK repeats.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U49069; AAC06146.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF057748; AAC64394.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

UniGene

Mm.325086

3D structure databases

ModBase

Q61143.

PTM databases

PhosphoSite

Q61143; -.

Organism-specific databases

MGI

MGI:109523; Trpc6.

Gene expression databases

ArrayExpress

Q61143; -.

GermOnline

ENSMUSG00000031997; Mus musculus.

Ontologies

GO:0015279;	Molecular function: store-operated calcium channel activity (inferred from direct assay from MGI).
GO:0007204;	Biological process: elevation of cytosolic calcium ion concentration (inferred from direct assay from MGI).
QuickGo view.

Family and domain databases

InterPro

IPR002110; ANK.
IPR005821; Ion_trans.
IPR002153; Trans_rcpt.
IPR013555; TRP_2.
IPR004729; TRP_channel.
IPR005462; TRP_channel6.
Graphical view of domain structure.

Gene3D

G3DSA:1.25.40.20; ANK; 1.

Pfam

PF00023; Ank; 3.
PF00520; Ion_trans; 1.
PF08344; TRP_2; 1.
Pfam graphical view of domain structure.

PRINTS

PR01097; TRNSRECEPTRP.
PR01647; TRPCHANNEL6.

SMART

SM00248; ANK; 3.
SMART graphical view of domain structure.

TIGRFAMs

TIGR00870; trp; 1.

PROSITE

PS50297; ANK_REP_REGION; 1.
PS50088; ANK_REPEAT; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q61143.

Genome annotation databases

Ensembl

ENSMUSG00000031997; Mus musculus. [Contig view]

Phylogenomic databases

HOGENOM

Q61143; -.

HOVERGEN

Q61143; -.

Other

Q61143; -.

Trpc6; Mus musculus.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ANK repeat; Calcium; Calcium channel; Calcium transport; Glycoprotein; Ion transport; Ionic channel; Membrane; Phosphoprotein; Repeat; Transmembrane; Transport.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 930`	`930`	`Short transient receptor potential channel 6.`	`PRO_0000215323`
`TOPO_DOM`	`1 437`	`437`	`Cytoplasmic (Potential).`
`TRANSMEM`	`438 458`	`21`	`Potential.`
`TOPO_DOM`	`459 486`	`28`	`Extracellular (Potential).`
`TRANSMEM`	`487 507`	`21`	`Potential.`
`TOPO_DOM`	`508 520`	`13`	`Cytoplasmic (Potential).`
`TRANSMEM`	`521 541`	`21`	`Potential.`
`TOPO_DOM`	`542 591`	`50`	`Extracellular (Potential).`
`TRANSMEM`	`592 612`	`21`	`Potential.`
`TOPO_DOM`	`613 635`	`23`	`Cytoplasmic (Potential).`
`TRANSMEM`	`636 656`	`21`	`Potential.`
`TOPO_DOM`	`657 705`	`49`	`Extracellular (Potential).`
`TRANSMEM`	`706 726`	`21`	`Potential.`
`TOPO_DOM`	`727 930`	`204`	`Cytoplasmic (Potential).`
`REPEAT`	`131 160`	`30`	`ANK 1.`
`REPEAT`	`162 188`	`27`	`ANK 2.`
`REPEAT`	`217 246`	`30`	`ANK 3.`
`MOD_RES`	`69 69`		`Phosphothreonine (By similarity).`
`MOD_RES`	`814 814`		`Phosphoserine (By similarity).`
`MOD_RES`	`838 838`		`Phosphoserine (By similarity).`
`CARBOHYD`	`560 560`		`N-linked (GlcNAc...) (Potential).`
`CONFLICT`	`3 56`		`Missing (in Ref. 2).`
`CONFLICT`	`105 105`		`V -> A (in Ref. 2; AAC64394).`
`CONFLICT`	`114 114`		`W -> R (in Ref. 2; AAC64394).`
`CONFLICT`	`134 134`		`N -> D (in Ref. 2; AAC64394).`
`CONFLICT`	`184 184`		`S -> A (in Ref. 2; AAC64394).`
`CONFLICT`	`371 371`		`D -> Y (in Ref. 2; AAC64394).`
`CONFLICT`	`436 437`		`PR -> RG (in Ref. 2; AAC64394).`
`CONFLICT`	`905 905`		`S -> T (in Ref. 2; AAC64394).`

Sequence information

Length: 930 AA [This is the length of the unprocessed precursor]

Molecular weight: 106733 Da [This is the MW of the unprocessed precursor]

CRC64: CF21A426972732F3 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSQSPRFVTR RGGSLKAAPG AGTRRNESQD YLLMDELGDD GYPQLPLPPY GYYPSFRGNE 

        70         80         90        100        110        120 
NRLTHRRQTI LREKGRRLAN RGPAYMFNDH STSLSIEEER FLDAVEYGNI PVVWKMLEEC 

       130        140        150        160        170        180 
HSLNVNCVDY MGQNALQLAV ANEHLEITEL LLKKENLSRV GDALLLAISK GYVRIVEAIL 

       190        200        210        220        230        240 
NHPSFAEGKR LATSPSQSEL QQDDFYAYDE DGTRFSHDVT PIILAAHCQE YEIVHTLLRK 

       250        260        270        280        290        300 
GARIERPHDY FCKCTECSQK QKHDSFSHSR SRINAYKGLA SPAYLSLSSE DPVMTALELS 

       310        320        330        340        350        360 
NELAVLANIE KEFKNDYRKL SMQCKDFVVG LLDLCRNTEE VEAILNGDAE TRQPGDFGRP 

       370        380        390        400        410        420 
NLSRLKLAIK DEVKKFVAHP NCQQQLLSIW YENLSGLRQQ TMAVKFLVVL AVAIGLPFLA 

       430        440        450        460        470        480 
LIYWCAPCSK MGKILPRPFM KFVAHAASFT IFLGLLVMNA ADRFEGTKLL PNETSTDNAR 

       490        500        510        520        530        540 
QLFRMKTSCF SWMEMLIISW VIGMIWAECK EIWTQGPKEY LFELWNMLDF GMLAIFAASF 

       550        560        570        580        590        600 
IARFMAFWHA SKAQSIIDAN DTLKDLTKVT LGDNVKYYNL ARIKWDPTDP QIISEGLYAI 

       610        620        630        640        650        660 
AVVLSFSRIA YILPANESFG PLQISLGRTV KDIFKFMVIF IMVFVAFMIG MFNLYSYYIG 

       670        680        690        700        710        720 
AKQNEAFTTV EESFKTLFWA IFGLSEVKSV VINYNHKFIE NIGYVLYGVY NVTMVIVLLN 

       730        740        750        760        770        780 
MLIAMINSSF QEIEDDADVE WKFARAKLWF SYFEEGRTLP VPFNLVPSPK SLLYLLLKFK 

       790        800        810        820        830        840 
KWMCELIQGQ KQGFQEDAEM NKRNEEKKFG ISGSHEDLSK FSLDKNQLAH NKQSSTRSSE 

       850        860        870        880        890        900 
DYHLNSFSNP PRQYQKIMKR LIKRYVLQAQ IDKESDEVNE GELKEIKQDI SSLRYELLEE 

       910        920        930 
KSQNSEDLAE LIRKLGERLS LEPKLEESRR

Q61143 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools