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UniProtKB/Swiss-Prot entry Q61120

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SHC3_MOUSE
Primary accession number Q61120
Secondary accession numbers None
Integrated into Swiss-Prot on March 29, 2004
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 57)
Name and origin of the protein
Protein name SHC-transforming protein 3
Synonyms Src homology 2 domain-containing-transforming protein C3
SH2 domain protein C3
Neuronal Shc
N-Shc
Gene name
Name: Shc3
Synonyms: Nshc, ShcC
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1073/pnas.93.7.2729; PubMed=8610109 [NCBI, ExPASy, EBI, Israel, Japan]
O'Bryan J.P., Songyang Z., Cantley L., Der C.J., Pawson T.;
"A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain.";
Proc. Natl. Acad. Sci. U.S.A. 93:2729-2734(1996).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U46854; AAC52508.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_033193.2; -.
UniGene Mm.247622
3D structure databases
HSSP P29353; 1SHC. [HSSP ENTRY / PDB]
SMR Q61120; 16-190.
ModBase Q61120.
Protein-protein interaction databases
IntAct Q61120; -.
PTM databases
PhosphoSite Q61120; -.
Organism-specific databases
MGI MGI:106179; Shc3.
Gene expression databases
ArrayExpress Q61120; -.
GermOnline ENSMUSG00000021448; Mus musculus.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0007611; Biological process: learning or memory (inferred from mutant phenotype from MGI).
GO:0035249; Biological process: synaptic transmission, glutamatergic (inferred from mutant phenotype from MGI).
QuickGo view.
Family and domain databases
InterPro IPR011993; PH_type.
IPR006019; PID_domain.
IPR006020; PTB_PID.
IPR000980; SH2.
Graphical view of domain structure.
Gene3D G3DSA:2.30.29.30; PH_type; 1.
G3DSA:3.30.505.10; SH2; 1.
Pfam PF00640; PID; 1.
PF00017; SH2; 1.
Pfam graphical view of domain structure.
PRINTS PR00401; SH2DOMAIN.
PR00629; SHCPIDOMAIN.
ProDom PD000093; SH2; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00462; PTB; 1.
SM00252; SH2; 1.
SMART graphical view of domain structure.
PROSITE PS01179; PID; 1.
PS50001; SH2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q61120.
Genome annotation databases
Ensembl ENSMUSG00000021448; Mus musculus. [Contig view]
GeneID 20418; -.
KEGG mmu:20418; -.
Phylogenomic databases
HOGENOM Q61120; -.
HOVERGEN Q61120; -.
Other
SOURCE Shc3; Mus musculus.
ProtoNet Q61120.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Phosphoprotein; SH2 domain.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   474  474     SHC-transforming protein 3. PRO_0000097735
DOMAIN   29   214  186     PID. 
DOMAIN   379   470  92     SH2. 
REGION   215   378  164     CH1. 
Sequence information
Length: 474 AA [This is the length of the unprocessed precursor] Molecular weight: 52206 Da [This is the MW of the unprocessed precursor] CRC64: DEE6CBA83A54A6C4 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSATRKSRAG DEPLPRPPRG APHTSDQVLG PGVTYVVKYL GCIEVLRSMR SLDFSTRTQV 

        70         80         90        100        110        120 
TREAISRVCE RVPGAKGALK KRKPPSKMLS SILGKSNLQF AGMSISLTIS TASLNLRTPD 

       130        140        150        160        170        180 
SKQIIANHHM RSISFASGGD PDTTDYVAYV AKDPVNRRAC HILECCDGLA QDVIGSIGQA 

       190        200        210        220        230        240 
FELRFKQYLQ CPSKVPALQD RMQSLDEPWT EEEGDGPDHP YYNSVPTKMP PPGGFLDARL 

       250        260        270        280        290        300 
KGRPHAPEAA QFAGKEQTYY QGRHLGDTFG EDWQRAPTRQ GSLDIYSTAE GKTHMVPVGE 

       310        320        330        340        350        360 
TPTYVNTQPV PPQVWPAATS STESSPRKDL FDMKPFEDAL RNQPLGPMLS KAASVECISP 

       370        380        390        400        410        420 
VTPRAPDARM LEELNAEPWY QGEMSRKEAE ALLREDGDFL VRKSTTNPGS FVLTGMHNGQ 

       430        440        450        460        470 
AKHLLLVDPE GTIRTKDRVF DSISHLINYH LESSLPIVSA GSELCLQQPV ERKP
Q61120 in FASTA format

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