FUNCTION: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrB may have a function in energy transduction (By similarity).
CATALYTIC ACTIVITY: Coenzyme B + coenzyme M + methanophenazine = N-(7-((2-sulfoethyl)dithio)heptanoyl)-O³-phospho-L-threonine + dihydromethanophenazine.
PATHWAY: Cofactor metabolism; coenzyme B/coenzyme M regeneration; coenzyme B and coenzyme M from CoB-CoM heterodisulfide: step 1/1 .
SUBUNIT: The heterodisulfide reductase is composed of three subunits; hdrA, hdrB and hdrC (By similarity).
SIMILARITY: Belongs to the hdrB family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L77117; AAB98868.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

G64407; G64407.

RefSeq

NP_247858.1; -.

3D structure databases

ModBase

Q58273.

Enzyme and pathway databases

BioCyc

MJAN243232:MJ_0863-MON; -.

Ontologies

GO:0051912;	Molecular function: CoB--CoM heterodisulfide reductase activity (inferred from electronic annotation from EC).
GO:0015948;	Biological process: methanogenesis (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR017678; CoB/CoM_hetero-S_rdtase_bsu.
IPR004017; Cys_rich_region.
Graphical view of domain structure.

Pfam

PF02754; CCG; 2.
Pfam graphical view of domain structure.

Genome annotation databases

1451752; -.

L77117_GR; MJ0863.

mja:MJ0863; -.

fig|243232.1.peg.895; -.

TIGR

MJ0863; -.

Phylogenomic databases

HOGENOM

Q58273; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Methanogenesis; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 295`	`295`		`CoB--CoM heterodisulfide reductase subunit B 2.`	`PRO_0000150066`

Sequence information

Length: 295 AA [This is the length of the unprocessed precursor]

Molecular weight: 32789 Da [This is the MW of the unprocessed precursor]

CRC64: 35A2A278491E8ED0 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKYAFFLGCI MPHRYPGVEK ATKIVMEELG VELEYMPGAS CCPAPGVFGS FDQKTWLTLA 

        70         80         90        100        110        120 
ARNLCIAEEM GLDIVTVCNG CYGSLFEAAH ILHENKEALD FVNEKLDKIG KQYKGTIKVR 

       130        140        150        160        170        180 
HFAELIYKDI GVDKIKEKVV KPLDVLNVAI HYGCHFLKPS DVKHLDSPER PKLLEEIVAA 

       190        200        210        220        230        240 
TGAKPVMYRD YLMCCGAGGG VRARFLPTAL DMTKEKIRNM LEAGADCTVN VCPFCHLQFD 

       250        260        270        280        290 
RGQVEIKEKF GEEYKLPVLH LSQLLGLAFG MKPEDLAVSV HAIPVDPVLK KLGIE

Q58273 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools