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UniProtKB/Swiss-Prot entry Q54I10


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MMSA_DICDI
Primary accession number Q54I10
Secondary accession numbers None
Integrated into Swiss-Prot on April 8, 2008
Sequence was last modified on May 24, 2005 (Sequence version 1)
Annotations were last modified on    September 23, 2008 (Entry version 21)
Name and origin of the protein
Protein name Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial [Precursor]
Synonyms MMSDH
Malonate-semialdehyde dehydrogenase [acylating]
EC 1.2.1.27
EC 1.2.1.18
Gene name
Name: mmsdh
Synonyms: aldh6
ORFNames: DDB_0231483
From
Dictyostelium discoideum (Slime mold) [TaxID: 44689] 
Taxonomy Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
DOI=10.1038/nature03481; PubMed=15875012 [NCBI, ExPASy, EBI, Israel, Japan]
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AAFI02000130; EAL62892.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_636395.1; -.
3D structure databases
ModBase Q54I10.
Organism-specific databases
dictyBase DDB0231483; mmsdh.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR010061; MeMal-semiAld_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
PTHR11699:SF27; MMSDH; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01722; MMSDH; 1.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; FALSE_NEG.
BLOCKS Q54I10.
ProtoNet Q54I10.
Genome annotation databases
GeneID 3387978; -.
KEGG ddi:DDB_0231483; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Mitochondrion; NAD; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    26  26     Mitochondrion (Potential). 
CHAIN   27   528  502     Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial. PRO_0000327926
NP_BIND   199   203  5     NAD (Potential). 
NP_BIND   251   256  6     NAD (Potential). 
ACT_SITE   307   307        Nucleophile (By similarity). 
BINDING   408   408        NAD (Potential). 
Sequence information
Length: 528 AA [This is the length of the unprocessed precursor] Molecular weight: 56696 Da [This is the MW of the unprocessed precursor] CRC64: D83629D894CC3E68 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLSFKFAKSA SKVIGNRNFH SSSASLANTT KLFINGKFVE SKTKEWLEVR NPATQELVTK 

        70         80         90        100        110        120 
VPVSTKEEME AAVKAASDAF PAWRDTSVSN RSRIISNYKN LINKNMDKIA AIITEEQGKT 

       130        140        150        160        170        180 
LPDAKGDVFR GLEVVEHSVN VASLMMGETV ENVSKNVDIY SYVQPLGVCA GITPFNFPAM 

       190        200        210        220        230        240 
IPLWMFPLAI ACGNTFVLKP SERVPSASMF LVQLAQEAGV PDGVVNVIHG GKEAVNFICD 

       250        260        270        280        290        300 
APEVRAISFV GADQAGRHIH ARGTANGKRV QSNMAAKNHA TIVPDAHKER TLDALTGAAF 

       310        320        330        340        350        360 
GASGQRCMAL SAAVFVGESK NWIPELAERA KKLKVAGGAA PGADLGPVIS AASKQRIHEL 

       370        380        390        400        410        420 
IQSGIDEGAK CILDGRNVVV DPEFSKGNFV GPTILTDVKP HMRCYKEEIF GPVLVCLNVD 

       430        440        450        460        470        480 
TVDQAIQLIN ANPYGNGTAV FTSSGAVARK YQREIDVGQV GINLPIPVPL PFFSFTGSRG 

       490        500        510        520 
SFVGAGHFYG KTGVQFFTQI KTITSNWRDD DISHGVSSSM NMPILGKN 

Q54I10 in FASTA format

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