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UniProtKB/Swiss-Prot entry Q4UKR1

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDH_RICFE
Primary accession number Q4UKR1
Secondary accession numbers None
Integrated into Swiss-Prot on June 26, 2007
Sequence was last modified on June 26, 2007 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 25)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NADP]
Synonyms IDH
EC 1.1.1.42
Oxalosuccinate decarboxylase
NADP(+)-specific ICDH
IDP
Gene name
Name: icd
OrderedLocusNames: RF_1015
From
Rickettsia felis (Rickettsia azadi) [TaxID: 42862] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC VR-1525 / URRWXCal2;
DOI=10.1371/journal.pbio.0030248; PubMed=15984913 [NCBI, ExPASy, EBI, Israel, Japan]
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.;
"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite.";
PLoS Biol. 3:1-12(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000053; AAY61866.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_247031.1; -.
3D structure databases
ModBase Q4UKR1.
Enzyme and pathway databases
BioCyc RFEL315456:RF_1015-MON; -.
Ontologies
GO
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006097; Biological process: glyoxylate cycle (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001804; IsoCit_IM_DHase.
IPR014273; Isocitrate_DH_bac.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR02924; ICDH_alpha; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q4UKR1.
ProtoNet Q4UKR1.
Genome annotation databases
GeneID 3401026; -.
GenomeReviews CP000053_GR; RF_1015.
KEGG rfe:RF_1015; -.
NMPDR fig|315456.3.peg.1015; -.
Phylogenomic databases
HOGENOM Q4UKR1; -.
Genome annotation databases
CMR Q4UKR1; RF_1015.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Glyoxylate bypass; Magnesium; Metal-binding; NADP; Oxidoreductase; Phosphoprotein; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   483  483     Isocitrate dehydrogenase [NADP]. PRO_0000292203
METAL   208   208        Magnesium or manganese (By similarity). 
METAL   232   232        Magnesium or manganese (By similarity). 
METAL   236   236        Magnesium or manganese (By similarity). 
BINDING   89    89        Substrate (By similarity). 
BINDING   99    99        Substrate (By similarity). 
BINDING   121   121        Substrate (By similarity). 
BINDING   208   208        Substrate (By similarity). 
SITE   128   128  1     Critical for catalysis (By similarity). 
SITE   175   175  1     Critical for catalysis (By similarity). 
MOD_RES   83    83        Phosphoserine (By similarity). 
Sequence information
Length: 483 AA [This is the length of the unprocessed precursor] Molecular weight: 54062 Da [This is the MW of the unprocessed precursor] CRC64: 57322A4AD6884B3C [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAEFTPITIA YGDGIGPEIM EAVLYILRKA EARIRLETIE VGEKLYKKHY TSGISEESWE 

        70         80         90        100        110        120 
SIQRTGIILK APITTPQGGG YKSLNVTIRK TLQLFANIRP SVSFHPFTMT LHPHLNLTII 

       130        140        150        160        170        180 
RENEEDLYAG IEYRQTHNMY ESIKLISHTG CEKIIRYAFE YAVKNNRKKV TCLSKDNIMK 

       190        200        210        220        230        240 
FSDGVFHKIF NEIAKEYPQI NNEHYIIDIG TARLATKPEI FDVIVTSNLY GDIISDVAAE 

       250        260        270        280        290        300 
ISGSVGLAGS ANIGQHYAMF EAVHGSAPDI AGKDIANPSG LLNAAIMMLV HIGQGDIASL 

       310        320        330        340        350        360 
IENAWKKTIE DGVHTADIYN EQNSSKKVGT KEFAEEVTKR LGQIPTKLPK ADYPLIAEKQ 

       370        380        390        400        410        420 
ESNIDYKIDT NEVKKLVGTD IFVNMNISSA HDIADKINKL DLGNIELKTI SSKGLKLWPR 

       430        440        450        460        470        480 
DTRFETISDH WCCRFMNKDG TEIKHLDITR LLEALSKANI DFIKVENLFE FDGVAGYSLA 


QGE
Q4UKR1 in FASTA format

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