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UniProtKB/Swiss-Prot entry P12841


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FOS_RAT
Primary accession number P12841
Secondary accession number Q4FDN1
Integrated into Swiss-Prot on October 1, 1989
Sequence was last modified on October 1, 1989 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 69)
Name and origin of the protein
Protein name Proto-oncogene protein c-fos
Synonym Cellular oncogene fos
Gene name
Name: Fos
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3325886 [NCBI, ExPASy, EBI, Israel, Japan]
Curran T., Gordon M.B., Rubino K.L., Sambucetti L.C.;
"Isolation and characterization of the c-fos(rat) cDNA and analysis of post-translational modification in vitro.";
Oncogene 2:79-84(1987).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Sprague-Dawley;
TISSUE=Liver;
Weiler E.;
"cFOS expression in rat.";
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
[3]
DNA-BINDING.
PubMed=2105492 [NCBI, ExPASy, EBI, Israel, Japan]
Abate C., Luk D., Gentz R., Rauscher F.J. III, Curran T.;
"Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: both Fos and Jun contact DNA directly.";
Proc. Natl. Acad. Sci. U.S.A. 87:1032-1036(1990).
[4]
INTERACTION WITH MAFB.
DOI=10.1006/bbrc.1998.8447; PubMed=9571165 [NCBI, ExPASy, EBI, Israel, Japan]
Matsushima-Hibiya Y., Nishi S., Sakai M.;
"Rat maf-related factors: the specificities of DNA binding and heterodimer formation.";
Biochem. Biophys. Res. Commun. 245:412-418(1998).
Comments
  • FUNCTION: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.
  • SUBUNIT: Heterodimer. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with MAFB.
  • SUBCELLULAR LOCATION: Nucleus.
  • INDUCTION: C-fos expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury.
  • SIMILARITY: Belongs to the bZIP family. Fos subfamily.
  • SIMILARITY: Contains 1 bZIP domain.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X06769; CAA29937.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
DQ089699; AAZ13764.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A28263; TVRTFS.
RefSeq NP_071533.1; -.
UniGene Rn.103750
3D structure databases
HSSP P01100; 1FOS. [HSSP ENTRY / PDB]
SMR P12841; 139-198.
ModBase P12841.
Protein-protein interaction databases
DIP DIP:6001N; -.
PTM databases
PhosphoSite P12841; -.
Organism-specific databases
RGD 2626; Fos.
Gene expression databases
ArrayExpress P12841; -.
GermOnline ENSRNOG00000008015; Rattus norvegicus.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred from direct assay from MGI).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR011700; bZIP_2.
IPR000837; Leuzip_Fos.
IPR004827; TF_bZIP.
Graphical view of domain structure.
Pfam PF07716; bZIP_2; 1.
Pfam graphical view of domain structure.
PRINTS PR00042; LEUZIPPRFOS.
SMART SM00338; BRLZ; 1.
SMART graphical view of domain structure.
PROSITE PS50217; BZIP; 1.
PS00036; BZIP_BASIC; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P12841.
Genome annotation databases
Ensembl ENSRNOG00000008015; Rattus norvegicus. [Contig view]
GeneID 314322; -.
KEGG rno:314322; -.
Phylogenomic databases
HOVERGEN P12841; -.
Other
ProtoNet P12841.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
DNA-binding; Nucleus; Phosphoprotein; Proto-oncogene; Ubl conjugation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   380  380     Proto-oncogene protein c-fos. PRO_0000076469
DOMAIN   165   193  29     Leucine-zipper. 
DNA_BIND   139   160  22     Basic motif. 
CROSSLNK   113   113        Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) (By similarity). 
Sequence information
Length: 380 AA [This is the length of the unprocessed precursor] Molecular weight: 40927 Da [This is the MW of the unprocessed precursor] CRC64: E62D16A88CB2BEE9 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MMFSGFNADY EASSSRCSSA SPAGDSLSYY HSPADSFSSM GSPVNTQDFC ADLSVSSANF 

        70         80         90        100        110        120 
IPTVTAISTS PDLQWLVQPT LVSSVAPSQT RAPHPYGLPT PSTGAYARAG VVKTMSGGRA 

       130        140        150        160        170        180 
QSIGRRGKVE QLSPEEEEKR RIRRERNKMA AAKCRNRRRE LTDTLQAETD QLEDEKSALQ 

       190        200        210        220        230        240 
TEIANLLKEK EKLEFILAAH RPACKIPNDL GFPEEMSVTS LDLTGGLPEA TTPESEEAFT 

       250        260        270        280        290        300 
LPLLNDPEPK PSLEPVKNIS NMELKAEPFD DFLFPASSRP SGSETARSVP DVDLSGSFYA 

       310        320        330        340        350        360 
ADWEPLHSSS LGMGPMVTEL EPLCTPVVTC TPSCTTYTSS FVFTYPEADS FPSCAAAHRK 

       370        380 
GSSSNEPSSD SLSSPTLLAL 

P12841 in FASTA format

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