NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
STRAIN=cv. Y-63;
PubMed=8987656 [NCBI, ExPASy, EBI, Israel, Japan]
Kawai S., Mori A., Shiokawa T., Kajita S., Katayama Y., Morohoshi N.;
"Isolation and analysis of cinnamic acid 4-hydroxylase homologous genes from a hybrid aspen, Populus kitakamiensis.";
Biosci. Biotechnol. Biochem. 60:1586-1597(1996).

Comments

FUNCTION: Controls carbon flux to pigments essential for pollination or UV protection, to numerous pytoalexins synthesized by plants when challenged by pathogens, and to lignins.
CATALYTIC ACTIVITY: Trans-cinnamate + NADPH + O₂ = 4-hydroxycinnamate + NADP⁺ + H₂O.
COFACTOR: Heme group (By similarity).
PATHWAY: Phenylpropanoid metabolism; 4-coumaric acid biosynthesis; 4-coumaric acid from trans-cinnamic acid: step 1/1 .
SIMILARITY: Belongs to the cytochrome P450 family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

D82812; BAA11576.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
D82815; BAA11579.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

Q43054.

Ontologies

GO:0016710;	Molecular function: trans-cinnamate 4-monooxygenase activity (inferred from electronic annotation from EC).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001128; Cyt_P450.
IPR002401; Cyt_P450_E_grp-I.
Graphical view of domain structure.

Gene3D

G3DSA:1.10.630.10; Cyt_P450; 1.

PANTHER

PTHR19383; Cyt_P450; 1.

Pfam

PF00067; p450; 1.
Pfam graphical view of domain structure.

PRINTS

PR00463; EP450I.
PR00385; P450.

PROSITE

PS00086; CYTOCHROME_P450; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Heme; Iron; Metal-binding; Monooxygenase; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 505`	`505`	`Trans-cinnamate 4-monooxygenase.`	`PRO_0000052251`
`METAL`	`447 447`		`Iron (heme axial ligand) (By similarity).`

Sequence information

Length: 505 AA [This is the length of the unprocessed precursor]

Molecular weight: 57973 Da [This is the MW of the unprocessed precursor]

CRC64: FA97C0FA9B138151 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDLLLLEKTL LGSFVAVLVA ILVSKLRGKR FKLPPGPLPV PVFGNWLQVG DDLNHRNLTD 

        70         80         90        100        110        120 
LAKKFGDIFL LRMGQRNLVV VSSPDLSKEV LHTQGVEFGS RTRNVVFDIF TGKGQDMVFT 

       130        140        150        160        170        180 
VYGEHWRKMR RIMTVPFFTN KVVQQYRYGW EEEAAQVVED VKKNPEAATN GIVLRRRLQL 

       190        200        210        220        230        240 
MMYNNMYRIM FDRRFESEDD PLFNKLKALN GERSRLAQSF DYNYGDFIPI LRPFLRGYLK 

       250        260        270        280        290        300 
ICQEVKERRL QLFKDYFVDE RKKLASTKNM SNEGLKCAID HILDAQKKGE INEDNVLYIV 

       310        320        330        340        350        360 
ENINVAAIET TLWSIEWGIA ELVNHPEIQK KLRHELDTLL GPGHQITEPD TYKLPYLNAV 

       370        380        390        400        410        420 
VKETLRLRMA IPLLVPHMNL HDAKLGGFDI PAESKILVNA WWLANNPAHW KNPEEFRPER 

       430        440        450        460        470        480 
FLEEGAKVEA NGNDFRYLPF GVGRRSCPGI ILALPILGIT LGRLVQNFEL LPPPGQSKID 

       490        500 
TSEKGGQFSL HILKHSTIVA KPRSF

Q43054 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools