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UniProtKB/Swiss-Prot entry Q3JKG9

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LEU3_BURP1
Primary accession number Q3JKG9
Secondary accession numbers None
Integrated into Swiss-Prot on September 19, 2006
Sequence was last modified on November 8, 2005 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 25)
Name and origin of the protein
Protein name 3-isopropylmalate dehydrogenase
Synonyms EC 1.1.1.85
Beta-IPM dehydrogenase
IMDH
3-IPM-DH
Gene name
Name: leuB
OrderedLocusNames: BURPS1710b_A0775
From
Burkholderia pseudomallei (strain 1710b) [TaxID: 320372] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Burkholderia; pseudomallei group.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Woods D.E., Nierman W.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000125; ABA53170.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_335934.1; -.
3D structure databases
ModBase Q3JKG9.
Enzyme and pathway databases
BioCyc BPSE320372:BURPS1710B_B0915-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003862; Molecular function: 3-isopropylmalate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0030145; Molecular function: manganese ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0009098; Biological process: leucine biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_01033; -; 1.
PBIL [Tree]
InterPro IPR004429; 3-isopropylmalate_DHase.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
PTHR11835:SF13; IPMDH; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00169; leuB; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q3JKG9.
ProtoNet Q3JKG9.
Genome annotation databases
GeneID 3693001; -.
GenomeReviews CP000125_GR; BURPS1710b_A0775.
KEGG bpm:BURPS1710b_A0775; -.
TIGR BURPS1710b_A0775; -.
Phylogenomic databases
HOGENOM Q3JKG9; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Cytoplasm; Leucine biosynthesis; Magnesium; Manganese; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   355  355     3-isopropylmalate dehydrogenase. PRO_0000250107
NP_BIND   280   292  13     NAD (By similarity). 
METAL   222   222        Magnesium or manganese (By similarity). 
METAL   246   246        Magnesium or manganese (By similarity). 
METAL   250   250        Magnesium or manganese (By similarity). 
BINDING   90    90        Substrate (By similarity). 
BINDING   100   100        Substrate (By similarity). 
BINDING   128   128        Substrate (By similarity). 
BINDING   222   222        Substrate (By similarity). 
SITE   135   135  1     Important for catalysis (By similarity). 
SITE   190   190  1     Important for catalysis (By similarity). 
Sequence information
Length: 355 AA [This is the length of the unprocessed precursor] Molecular weight: 38187 Da [This is the MW of the unprocessed precursor] CRC64: 8BB994DF67538F7A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKIAVLPGDG IGPEIVNEAV KVLNALDEKF ELEQAPVGGA GYEASGHPLP DATLALAKEA 

        70         80         90        100        110        120 
DAILFGAVGD WKYDSLERAL RPEQAILGLR KHLELFANFR PAICYPQLVD ASPLKPELVA 

       130        140        150        160        170        180 
GLDILIVREL NGDIYFGQPR GVRAAPDGPF AGAREGFDTM RYSEPEVRRI AHVAFQAARK 

       190        200        210        220        230        240 
RAKKLLSVDK SNVLETSQFW RDVMIDVSKE YADVELSHMY VDNAAMQLAK APKQFDVIVT 

       250        260        270        280        290        300 
GNMFGDILSD EASMLTGSIG MLPSASLDQR NKGLYEPSHG SAPDIAGKGI ANPLATILSA 

       310        320        330        340        350 
AMLLRYSLNR AEQADRIERA VKAVLEQGYR TGDIATPGCK QVGTAAMGDA VVAAL
Q3JKG9 in FASTA format

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