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UniProtKB/Swiss-Prot entry Q37619

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NDUS2_PROWI
Primary accession number Q37619
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 52)
Name and origin of the protein
Protein name NADH-ubiquinone oxidoreductase 49 kDa subunit
Synonyms EC 1.6.5.3
EC 1.6.99.3
NADH dehydrogenase subunit 7
Gene name
Name: NAD7
From
Prototheca wickerhamii [TaxID: 3111] 
Encoded on Mitochondrion.
Taxonomy Eukaryota; Viridiplantae; Chlorophyta; Trebouxiophyceae; Chlorellales; Chlorellaceae; Prototheca.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=263-11;
DOI=10.1006/jmbi.1994.1210; PubMed=8133522 [NCBI, ExPASy, EBI, Israel, Japan]
Wolff G., Plante I., Lang B.F., Kueck U., Burger G.;
"Complete sequence of the mitochondrial DNA of the chlorophyte alga Prototheca wickerhamii. Gene content and genome organization.";
J. Mol. Biol. 237:75-86(1994).
Comments
  • FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme.
  • CATALYTIC ACTIVITY: NADH + ubiquinone = NAD+ + ubiquinol.
  • CATALYTIC ACTIVITY: NADH + acceptor = NAD+ + reduced acceptor.
  • SUBCELLULAR LOCATION: Mitochondrion.
  • SIMILARITY: Belongs to the complex I 49 kDa subunit family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U02970; AAD12640.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T11921; T11921.
RefSeq NP_042252.1; -.
3D structure databases
ModBase Q37619.
Ontologies
GO
GO:0005746; Cellular component: mitochondrial respiratory chain (inferred from electronic annotation from UniProtKB-KW).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0008137; Molecular function: NADH dehydrogenase (ubiquinone) activity (inferred from electronic annotation from EC).
GO:0022900; Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810; Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR014029; NADH-UbQ_OxRdtase_49kDa_CS.
IPR010219; NADH_DH_1_dsu.
IPR001135; NADH_UbQ_OxRdtase_49kDa.
Graphical view of domain structure.
Pfam PF00346; Complex1_49kDa; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01962; NuoD; 1.
PROSITE PS00535; COMPLEX1_49K; 1.
ProtoNet Q37619.
Genome annotation databases
GeneID 802126; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Electron transport; Mitochondrion; NAD; Oxidoreductase; Respiratory chain; Transport; Ubiquinone.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   400  400     NADH-ubiquinone oxidoreductase 49 kDa subunit. PRO_0000118591
Sequence information
Length: 400 AA [This is the length of the unprocessed precursor] Molecular weight: 45810 Da [This is the MW of the unprocessed precursor] CRC64: 7227458FE80BC9D2 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MALEKIITAP KYKNFTINFG PQHPAAHGVL RLVLEMNGEV VQRSDPHIGL LHRGTEKLIE 

        70         80         90        100        110        120 
YKNYLQALPY FDRLDYVSMM CQEHAYSLAV EKLLNISKDI PLRAQYIRVL FSEITRILNH 

       130        140        150        160        170        180 
LLAVTCHAMD VGALTPFLWG FEEREKLMEF YERVSGARMH AAYIRPGGVA LDLPLGLCED 

       190        200        210        220        230        240 
IYKFSKQFAS RIDEIEEMLT SNRIWKQRLV DVGVVSAEQA LDWSFSGVLL RGSGIAWDLR 

       250        260        270        280        290        300 
KTQPYEVYDR MKFNIPVGTR GDCYDRYLIR VQEMRESLRI VMQTINEMSK GIIRLDDRKI 

       310        320        330        340        350        360 
TPPTRDQMKQ SMESLIHHFK FYTGGFVVPA GETYTAVEAP KGEFGVYLVS NGTSKPYRCK 

       370        380        390        400 
IRAPGFAHLQ GLDFMARNHM LADVVTIIGT QDIVFGEVDR
Q37619 in FASTA format

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