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UniProtKB/Swiss-Prot entry Q2YR04

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AROE_BRUA2
Primary accession number Q2YR04
Secondary accession numbers None
Integrated into Swiss-Prot on March 18, 2008
Sequence was last modified on March 18, 2008 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 30)
Name and origin of the protein
Protein name Shikimate dehydrogenase
Synonym EC 1.1.1.25
Gene name
Name: aroE
OrderedLocusNames: BAB1_2070
From
Brucella abortus (strain 2308) [TaxID: 359391] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Brucellaceae; Brucella.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1128/IAI.73.12.8353-8361.2005; PubMed=16299333 [NCBI, ExPASy, EBI, Israel, Japan]
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.;
"Whole-genome analyses of speciation events in pathogenic Brucellae.";
Infect. Immun. 73:8353-8361(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AM040264; CAJ12026.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_415398.1; -.
3D structure databases
ModBase Q2YR04.
Enzyme and pathway databases
BioCyc BMEL359391:BAB1_2070-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0050661; Molecular function: NADP binding (inferred from electronic annotation from InterPro).
GO:0004764; Molecular function: shikimate 5-dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009073; Biological process: aromatic amino acid family biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_00222; -; 1.
PBIL [Tree]
InterPro IPR016040; NAD(P)-bd.
IPR011342; Quinate/shikimate_5-DHase.
IPR013708; Shikimate_DHase-bd_N.
IPR006151; Shikm_DHase/Glu-tRNA_Rdtase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF01488; Shikimate_DH; 1.
PF08501; Shikimate_dh_N; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00507; aroE; 1.
ProtoNet Q2YR04.
Genome annotation databases
GeneID 3788516; -.
GenomeReviews AM040264_GR; BAB1_2070.
KEGG bmf:BAB1_2070; -.
Phylogenomic databases
HOGENOM Q2YR04; -.
Genome annotation databases
CMR Q2YR04; BAB1_2070.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   289  289     Shikimate dehydrogenase. PRO_0000325109
NP_BIND   134   138  5     NADP (By similarity). 
ACT_SITE   73    73        Proton acceptor (Potential). 
Sequence information
Length: 289 AA [This is the length of the unprocessed precursor] Molecular weight: 30520 Da [This is the MW of the unprocessed precursor] CRC64: B1B17A56EED18496 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDDKSMARGR KAFVTGFPIR HSRSPLIHGF WLKELGIDGS YEAVEVKPED FSSFAASLAA 

        70         80         90        100        110        120 
NGFAGGNVTI PHKEAAYAAA ESLDEAARAI GAVNTLWLEN GRLCGGNTDA YGFAANLDAS 

       130        140        150        160        170        180 
APGWDKADRA LVLGAGGASR AVVHALLSRG VCHVSVVNRT LSRAEELAAH FGARVYAHSW 

       190        200        210        220        230        240 
DEAQALVSNA GLIVNTTALG MSGHGEGQDF PIDLTCAPKE AVATDIVYVP LRTAFLNKAE 

       250        260        270        280 
KAGLKTVDGL GMLLHQAVPG FERWFGQRPQ VTQALREHIL ADMAKAGAL
Q2YR04 in FASTA format

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