[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Ochiai H., Inoue Y., Takeya M., Sasaki A., Kaku H.; "Genome sequence of Xanthomonas oryzae pv. oryzae suggests contribution of large numbers of effector genes and insertion sequences to its race diversity."; Jpn. Agric. Res. Q. 39:275-287(2005).

Comments

FUNCTION: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity).
CATALYTIC ACTIVITY: 3-hydroxyanthranilate + O₂ = 2-amino-3-carboxymuconate semialdehyde.
COFACTOR: Binds 2 Fe(2+) ions per subunit (By similarity).
SUBUNIT: Homodimer (By similarity).
SIMILARITY: Belongs to the 3-HAO family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AP008229; BAE69057.1; ALT_INIT; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_451331.1; -.

3D structure databases

ModBase

Q2P320.

Enzyme and pathway databases

BioCyc

XORY342109:XOO2302-MON; -.

Ontologies

GO:0000334;	Molecular function: 3-hydroxyanthranilate 3,4-dioxygenase activity (inferred from electronic annotation from HAMAP).
GO:0008198;	Molecular function: ferrous iron binding (inferred from electronic annotation from HAMAP).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

HAMAP

MF_00825; -; 1.
PBIL [Tree]

InterPro

IPR010329; 3hydroanth_dOase.
Graphical view of domain structure.

Pfam

PF06052; 3-HAO; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR03037; anthran_nbaC; 1.

ProtoNet

Q2P320.

Genome annotation databases

GeneID

3856660; -.

GenomeReviews

AP008229_GR; XOO2302.

KEGG

xom:XOO_2302; -.

Phylogenomic databases

HOGENOM

Q2P320; -.

Genome annotation databases

CMR

Q2P320; XOO2302.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 176`	`176`	`3-hydroxyanthranilate 3,4-dioxygenase.`	`PRO_0000245483`
`METAL`	`48 48`		`Iron 1; catalytic (By similarity).`
`METAL`	`54 54`		`Iron 1; catalytic (By similarity).`
`METAL`	`92 92`		`Iron 1; catalytic (By similarity).`
`METAL`	`121 121`		`Iron 2 (By similarity).`
`METAL`	`124 124`		`Iron 2 (By similarity).`
`METAL`	`158 158`		`Iron 2 (By similarity).`
`METAL`	`161 161`		`Iron 2 (By similarity).`
`BINDING`	`44 44`		`Dioxygen (By similarity).`
`BINDING`	`54 54`		`Substrate (By similarity).`
`BINDING`	`96 96`		`Substrate (By similarity).`
`BINDING`	`106 106`		`Substrate (By similarity).`

Sequence information

Length: 176 AA [This is the length of the unprocessed precursor]

Molecular weight: 20196 Da [This is the MW of the unprocessed precursor]

CRC64: 4274767A24F2B088 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLIPPINLHA WIEEHRHLLK PPVGNKCIQQ DGFIIMIVGG PNARTDYHYD EGPEWFFQLE 

        70         80         90        100        110        120 
GEMVLKVQDD GVARDIPIRA GEIFLLPPRV PHSPQRAAGS IGIVIERVRL PHEQDGLQWY 

       130        140        150        160        170 
CPQCNHKLYE AMFPLKNIET DFPPVFDHFY RSLALRTCSQ CGHLHPAPER YAAVED

Q2P320 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools