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UniProtKB/Swiss-Prot entry Q2GH90

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_EHRCR
Primary accession number Q2GH90
Secondary accession numbers None
Integrated into Swiss-Prot on March 18, 2008
Sequence was last modified on March 21, 2006 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 22)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: ECH_0373
From
Ehrlichia chaffeensis (strain Arkansas) [TaxID: 205920] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; Anaplasmataceae; Ehrlichia.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1371/journal.pgen.0020021; PubMed=16482227 [NCBI, ExPASy, EBI, Israel, Japan]
Dunning Hotopp J.C., Lin M., Madupu R., Crabtree J., Angiuoli S.V., Eisen J.A., Seshadri R., Ren Q., Wu M., Utterback T.R., Smith S., Lewis M., Khouri H., Zhang C., Niu H., Lin Q., Ohashi N., Zhi N., Nelson W.C., Brinkac L.M., Dodson R.J., Rosovitz M.J., Sundaram J.P., Daugherty S.C., Davidsen T., Durkin A.S., Gwinn M.L., Haft D.H., Selengut J.D., Sullivan S.A., Zafar N., Zhou L., Benahmed F., Forberger H., Halpin R., Mulligan S., Robinson J., White O., Rikihisa Y., Tettelin H.;
"Comparative genomics of emerging human ehrlichiosis agents.";
PLoS Genet. 2:208-222(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000236; ABD45465.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_507193.1; -.
3D structure databases
ModBase Q2GH90.
Enzyme and pathway databases
BioCyc ECHA205920:ECH_0373-MON; -.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00220; -; 1.
PBIL [Tree]
InterPro IPR006680; Amidohydro_1.
IPR004722; DHOmult.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.
ProDom PD000518; DHOase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00857; pyrC_multi; 1.
PROSITE PS00482; DIHYDROOROTASE_1; 1.
PS00483; DIHYDROOROTASE_2; 1.
ProtoNet Q2GH90.
Genome annotation databases
GeneID 3927284; -.
GenomeReviews CP000236_GR; ECH_0373.
KEGG ech:ECH_0373; -.
TIGR ECH_0373; -.
Phylogenomic databases
HOGENOM Q2GH90; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   447  447     Dihydroorotase. PRO_0000325593
METAL   81    81        Zinc 1 (By similarity). 
METAL   83    83        Zinc 1 (By similarity). 
METAL   161   161        Zinc 1; via carbamate group (By similarity). 
METAL   161   161        Zinc 2; via carbamate group (By similarity). 
METAL   198   198        Zinc 2 (By similarity). 
METAL   252   252        Zinc 2 (By similarity). 
METAL   325   325        Zinc 1 (By similarity). 
MOD_RES   161   161        N6-carboxylysine (By similarity). 
Sequence information
Length: 447 AA [This is the length of the unprocessed precursor] Molecular weight: 49167 Da [This is the MW of the unprocessed precursor] CRC64: A077FA4FA5361C26 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MYKQSWELLG NGQHADLTVA YINARIIDPE SKLDIRGSLL TKGDKIIDFG PDLFANGIPS 

        70         80         90        100        110        120 
TIDEVIDCNN NILLPGLIDI HVHFREPGQE HKETINTGSK SAAAGGITTV VCQPNTIPTI 

       130        140        150        160        170        180 
SSVITAKYIK MRALESAYVN IEFYASITKS DNSLSDMALL KEVGAVGFTD DGMPVMNALT 

       190        200        210        220        230        240 
MRQALSYSSM LDTVIAQHAE DLNISNNGCI NEGIISYELG LKGIPDISES IIVNRDIALM 

       250        260        270        280        290        300 
KNIKNVHYHI LHVSSQESLH IIKQAKSQGL KVTCEVTPHH FTLTERDIMT HGSLAKMNPP 

       310        320        330        340        350        360 
LRTENDRLSM IEGLKSGIID CIATDHAPHD INAKELPLDT AAFGIVGLET MLPISLELYH 

       370        380        390        400        410        420 
NGTMPLIDLL ATLTYKPADI IKVPRGRIKK DYVADLIILD LDHEWVVDIS KFASKSKNSP 

       430        440 
FHNRKVKGKV LRTIVSGKTT YKAEIII
Q2GH90 in FASTA format

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