[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=BG1016; Eanes W.F., Kirchner M., Yoon J., Biermann C., Wang I., McCartney M., Verrelli B.C.; Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: D-glucose 6-phosphate + NADP⁺ = D-glucono-1,5-lactone 6-phosphate + NADPH.
PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3 .
SIMILARITY: Belongs to the glucose-6-phosphate dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U42750; AAB02813.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P11413; 1QKI. [HSSP ENTRY / PDB]

ModBase

Q27638.

Organism-specific databases

FlyBase

FBgn0015691; Dyak\Zw.

Ontologies

GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001282; Glc-6-P_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR23429; G6PDH; 1.

Pfam

PF02781; G6PD_C; 1.
PF00479; G6PD_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000110; G6PD; 1.

PRINTS

PR00079; G6PDHDRGNASE.

ProDom

PD001129; G6PD; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR00871; zwf; 1.

PROSITE

PS00069; G6P_DEHYDROGENASE; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Carbohydrate metabolism; Glucose metabolism; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`<1 518`	`>518`	`Glucose-6-phosphate 1-dehydrogenase.`	`PRO_0000068094`
`ACT_SITE`	`261 261`		`Proton acceptor (By similarity).`
`BINDING`	`38 38`		`NADP (By similarity).`
`BINDING`	`70 70`		`NADP (By similarity).`
`BINDING`	`199 199`		`Substrate (By similarity).`
`BINDING`	`203 203`		`Substrate (By similarity).`
`NON_TER`	`1 1`

Sequence information

Length: 518 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 59938 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 6AFA194E1D3A3E8B [This is a checksum on the sequence]

        10         20         30         40         50         60 
DHTALDLIIK SLKSPTMVCE GTHFDGKIPH TFVIFGASGD LAKKKIYPKL WWFYRDDLLP 

        70         80         90        100        110        120 
KLTKFCGYAR SMLTVDSIKE QCLPYMKVQS HEQKKYEEFW ALNEYVSGRY DGRTGFELLN 

       130        140        150        160        170        180 
QQLELMENKN KANRIFYLAL PPSVFEEVTV NIKQICMSVC GWNRVIIEKP FGRDDASSQA 

       190        200        210        220        230        240 
LSDHLAALFH EDQLYRIDHY LGKEMVQNLM TIRFGNKILS STWNRENIAS VLITFKEPFG 

       250        260        270        280        290        300 
TQGRGGYFDE FGIIRDVMQN HLLQILSLVA MEKPVSCHPD DIRDEKVKVL KSIETLTLKD 

       310        320        330        340        350        360 
MVLGQYLGNP QGTTDDARTG YVEDPTVSDD SNTPTYALGV LKINNERWQG VPFILRCGKR 

       370        380        390        400        410        420 
LNERKAEVRI QYQDVPGDIF EGNTKRNELV IRVQPGEALY FKMMTKSPGI TFDIEETELD 

       430        440        450        460        470        480 
LTYEHRYKDS YLPDAYERLI LDVFCGSQMH FVRSDQLREA WRIFTPILHQ IEREHIRPIT 

       490        500        510 
YQYGSRGPKE ADRMCEENNF KYSGSYKWHG GKAATSNL

Q27638 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools