[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=AX3; DOI=10.1093/dnares/2.3.129; PubMed=8581739 [NCBI, ExPASy, EBI, Israel, Japan] Iwamoto M., Yanagisawa K., Tanaka Y.; "Mitochondrial ribosomal protein L11 gene of Dictyostelium discoideum resides not in the nuclear genome but in the mitochondrial genome."; DNA Res. 2:129-132(1995).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=AX3; DOI=10.1007/s004380051196; PubMed=10821186 [NCBI, ExPASy, EBI, Israel, Japan] Ogawa S., Yoshino R., Angata K., Iwamoto M., Pi M., Kuroe K., Matsuo K., Morio T., Urushihara H., Yanagisawa K., Tanaka Y.; "The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene content and genome organization."; Mol. Gen. Genet. 263:514-519(2000).

Comments

FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme (By similarity).
CATALYTIC ACTIVITY: NADH + ubiquinone = NAD⁺ + ubiquinol.
CATALYTIC ACTIVITY: NADH + acceptor = NAD⁺ + reduced acceptor.
SUBUNIT: Complex I is composed of about 45 different subunits (By similarity).
SUBCELLULAR LOCATION: Mitochondrion (By similarity).
SIMILARITY: Belongs to the complex I 49 kDa subunit family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

D21196; BAA04731.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB000109; BAA78067.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

T43763; T43763.

RefSeq

NP_050085.1; -.

3D structure databases

ModBase

Q23883.

Organism-specific databases

dictyBase

DDB_G0294030; nad7.

Ontologies

GO:0005746;	Cellular component: mitochondrial respiratory chain (inferred from electronic annotation from UniProtKB-KW).
GO:0009055;	Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0051287;	Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0008137;	Molecular function: NADH dehydrogenase (ubiquinone) activity (inferred from electronic annotation from EC).
GO:0022900;	Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810;	Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR014029; NADH-UbQ_OxRdtase_49kDa_CS.
IPR010219; NADH_DH_1_dsu.
IPR001135; NADH_UbQ_OxRdtase_49kDa.
Graphical view of domain structure.

Pfam

PF00346; Complex1_49kDa; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR01962; NuoD; 1.

PROSITE

PS00535; COMPLEX1_49K; 1.

ProtoNet

Q23883.

Genome annotation databases

GeneID

2193913; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Electron transport; Mitochondrion; NAD; Oxidoreductase; Respiratory chain; Transport; Ubiquinone.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 406`	`406`		`NADH-ubiquinone oxidoreductase 49 kDa subunit.`	`PRO_0000118589`

Sequence information

Length: 406 AA [This is the length of the unprocessed precursor]

Molecular weight: 46833 Da [This is the MW of the unprocessed precursor]

CRC64: 581BCF7AD71F86A8 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLNISKIFEE VKVMKNFTLN FGPQHPAAHG VLRLIVELES ENVVRVEPHI GLLHRGTEKL 

        70         80         90        100        110        120 
IEGKTYTQAL PYFDRLDYVS MNVQEHAYSL AVERLYLDSL DIELEIPQRA KVIRVLFSEI 

       130        140        150        160        170        180 
TRVLNHIMAT TTHAMDVGAL TPFLWAFEER EKLMEFYERV SGARMHAAYI RPGGVAFDLP 

       190        200        210        220        230        240 
MNISEDIYKF VIQYRKRLEE IEDMLINNRI WKQRLVDIGI VSAEEALNYG FTGPLLRGAG 

       250        260        270        280        290        300 
IVYDIRKNYP YDDYDKYDFK IIIGEENNSY TRFIIRMKEM YQSLSIIEQA LNNLRPGLIK 

       310        320        330        340        350        360 
LEGVNITAPD RAFVKKDMES CINHFKFFSE GFIIPANENY TIVEAPKGEF GIYLNANDTA 

       370        380        390        400 
KPYRCRIKAP GFLHLQGLNM MSKDHLLADV VTLIGTQDIV FGEVDR

Q23883 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools