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UniProtKB/Swiss-Prot entry Q16572

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name VACHT_HUMAN
Primary accession number Q16572
Secondary accession numbers None
Integrated into Swiss-Prot on September 19, 2003
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    May 5, 2009 (Entry version 71)
Name and origin of the protein
Protein name Vesicular acetylcholine transporter
Synonyms VAChT
Solute carrier family 18 member 3
Gene name
Name: SLC18A3
Synonyms: VACHT
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, AND TISSUE SPECIFICITY.
TISSUE=Brain;
PubMed=8071310 [NCBI, ExPASy, EBI, Israel, Japan]
Erickson J.D., Varoqui H., Schafer M.K.-H., Modi W., Diebler M.-F., Weihe E., Rand J.B., Eiden L.E., Bonner T.I., Usdin T.B.;
"Functional identification of a vesicular acetylcholine transporter and its expression from a 'cholinergic' gene locus.";
J. Biol. Chem. 269:21929-21932(1994).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U10554; AAB92675.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U09210; AAA20497.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC007765; AAH07765.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00017623; -.
PIR I38658; I38658.
RefSeq NP_003046.2; -.
UniGene Hs.654374
3D structure databases
ModBase Q16572.
Protein family/group databases
TCDB 2.A.1.2.28; major facilitator superfamily (MFS).
PTM databases
PhosphoSite Q16572; -.
Enzyme and pathway databases
Reactome REACT_13685; Synaptic Transmission.
Organism-specific databases
GeneCards GC10P050488; -.
H-InvDB HIX0008818; -.
HGNC HGNC:10936; SLC18A3.
GenAtlas SLC18A3.
MIM 600336; gene. [NCBI / EBI]
PharmGKB PA326; -.
Gene expression databases
ArrayExpress Q16572; -.
Bgee Q16572; -.
CleanEx HS_SLC18A3; -.
GermOnline ENSG00000187714; Homo sapiens.
Ontologies
GO
GO:0005887; Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0005624; Cellular component: membrane fraction (traceable author statement from ProtInc).
GO:0005277; Molecular function: acetylcholine transmembrane transporter activity (traceable author statement from ProtInc).
GO:0015870; Biological process: acetylcholine transport (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR011701; MFS_1.
Graphical view of domain structure.
Pfam PF07690; MFS_1; 1.
Pfam graphical view of domain structure.
PROSITE PS50850; MFS; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q16572; -.
Genome annotation databases
Ensembl ENSG00000187714; Homo sapiens. [Contig view]
GeneID 6572; -.
KEGG hsa:6572; -.
Phylogenomic databases
HOGENOM Q16572; -.
HOVERGEN Q16572; -.
Other
NextBio 25571; -.
SOURCE SLC18A3; Homo sapiens.
ProtoNet Q16572.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glycoprotein; Membrane; Neurotransmitter transport; Polymorphism; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   532  532     Vesicular acetylcholine transporter. PRO_0000127517
TOPO_DOM   1    33  33     Cytoplasmic (Potential). 
TRANSMEM   34    54  21     Potential. 
TOPO_DOM   55   125  71     Lumenal, vesicle (Potential). 
TRANSMEM   126   146  21     Potential. 
TOPO_DOM   147   152  6     Cytoplasmic (Potential). 
TRANSMEM   153   173  21     Potential. 
TOPO_DOM   174   182  9     Lumenal, vesicle (Potential). 
TRANSMEM   183   203  21     Potential. 
TOPO_DOM   204   213  10     Cytoplasmic (Potential). 
TRANSMEM   214   234  21     Potential. 
TOPO_DOM   235   242  8     Lumenal, vesicle (Potential). 
TRANSMEM   243   263  21     Potential. 
TOPO_DOM   264   289  26     Cytoplasmic (Potential). 
TRANSMEM   290   310  21     Potential. 
TOPO_DOM   311   325  15     Lumenal, vesicle (Potential). 
TRANSMEM   326   346  21     Potential. 
TOPO_DOM   347   356  10     Cytoplasmic (Potential). 
TRANSMEM   357   377  21     Potential. 
TOPO_DOM   378   388  11     Lumenal, vesicle (Potential). 
TRANSMEM   389   409  21     Potential. 
TOPO_DOM   410   422  13     Cytoplasmic (Potential). 
TRANSMEM   423   443  21     Potential. 
TOPO_DOM   444   447  4     Lumenal, vesicle (Potential). 
TRANSMEM   448   468  21     Potential. 
TOPO_DOM   469   532  64     Cytoplasmic (Potential). 
CARBOHYD   89    89        N-linked (GlcNAc...) (Potential). 
CARBOHYD   96    96        N-linked (GlcNAc...) (Potential). 
VARIANT   11    11  1     R -> Q (in dbSNP:rs8187732 [NCBI]). VAR_029152 
VARIANT   13    13  1     A -> P (in dbSNP:rs8187733 [NCBI]). VAR_020034 
VARIANT   29    29  1     R -> W (in dbSNP:rs8187734 [NCBI]). VAR_020035 
VARIANT   520   520  1     E -> A (in dbSNP:rs8187730 [NCBI]). VAR_024638 
Sequence information
Length: 532 AA [This is the length of the unprocessed precursor] Molecular weight: 56961 Da [This is the MW of the unprocessed precursor] CRC64: 445CDF48F59AD31D [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MESAEPAGQA RAAATKLSEA VGAALQEPRR QRRLVLVIVC VALLLDNMLY MVIVPIVPDY 

        70         80         90        100        110        120 
IAHMRGGGEG PTRTPEVWEP TLPLPTPANA SAYTANTSAS PTAAWPAGSA LRPRYPTESE 

       130        140        150        160        170        180 
DVKIGVLFAS KAILQLLVNP LSGPFIDRMS YDVPLLIGLG VMFASTVLFA FAEDYATLFA 

       190        200        210        220        230        240 
ARSLQGLGSA FADTSGIAMI ADKYPEEPER SRALGVALAF ISFGSLVAPP FGGILYEFAG 

       250        260        270        280        290        300 
KRVPFLVLAA VSLFDALLLL AVAKPFSAAA RARANLPVGT PIHRLMLDPY IAVVAGALTT 

       310        320        330        340        350        360 
CNIPLAFLEP TIATWMKHTM AASEWEMGMA WLPAFVPHVL GVYLTVRLAA RYPHLQWLYG 

       370        380        390        400        410        420 
ALGLAVIGAS SCIVPACRSF APLVVSLCGL CFGIALVDTA LLPTLAFLVD VRHVSVYGSV 

       430        440        450        460        470        480 
YAIADISYSV AYALGPIVAG HIVHSLGFEQ LSLGMGLANL LYAPVLLLLR NVGLLTRSRS 

       490        500        510        520        530 
ERDVLLDEPP QGLYDAVRLR ERPVSGQDGE PRSPPGPFDE CEDDYNYYYT RS
Q16572 in FASTA format

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