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UniProtKB/Swiss-Prot entry Q16288


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NTRK3_HUMAN
Primary accession number Q16288
Secondary accession numbers O75682 Q12827 Q16289
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on March 6, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 98)
Name and origin of the protein
Protein name NT-3 growth factor receptor [Precursor]
Synonyms EC 2.7.10.1
Neurotrophic tyrosine kinase receptor type 3
TrkC tyrosine kinase
GP145-TrkC
Trk-C
Gene name
Name: NTRK3
Synonyms: TRKC
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND C).
TISSUE=Fetal brain;
DOI=10.1006/geno.1994.1383; PubMed=7806211 [NCBI, ExPASy, EBI, Israel, Japan]
McGregor L.M., Baylin S.B., Griffin C.A., Hawkins A.L., Nelkin B.D.;
"Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant.";
Genomics 22:267-272(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C AND D), AND PARTIAL PROTEIN SEQUENCE.
TISSUE=Brain;
PubMed=7823156 [NCBI, ExPASy, EBI, Israel, Japan]
Shelton D.L., Sutherland J., Gripp J., Camerato T., Armanini M.P., Phillips H.S., Carroll K., Spencer S.D., Levinson A.D.;
"Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins.";
J. Neurosci. 15:477-491(1995).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1038/sj.onc.1202100; PubMed=9778053 [NCBI, ExPASy, EBI, Israel, Japan]
Ichaso N., Rodriguez R.E., Martin-Zanca D., Gonzalez-Sarmiento R.;
"Genomic characterization of the human trkC gene.";
Oncogene 17:1871-1875(1998).
[4]
X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 297-401, AND DISULFIDE BOND.
DOI=10.1006/jmbi.1999.2816; PubMed=10388563 [NCBI, ExPASy, EBI, Israel, Japan]
Ultsch M.H., Wiesmann C., Simmons L.C., Henrich J., Yang M., Reilly D., Bass S.H., de Vos A.M.;
"Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.";
J. Mol. Biol. 290:149-159(1999).
[5]
VARIANTS [LARGE SCALE ANALYSIS] ARG-149; CYS-306; LEU-307; GLN-336; TYR-677 AND GLN-678.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G., Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U05012; AAA75374.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S76475; AAB33111.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S76476; AAB33112.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ224521; CAA12029.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ224522; CAA12029.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ224523; CAA12029.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ224524; CAA12029.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ224525; CAA12029.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ224526; CAA12029.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ224527; CAA12029.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ224528; CAA12029.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ224529; CAA12029.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ224530; CAA12029.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ224531; CAA12029.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ224532; CAA12029.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ224533; CAA12029.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ224534; CAA12029.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ224535; CAA12029.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A55178; A55178.
I73632; I73632.
I73633; I73633.
RefSeq NP_001012338.1; -.
NP_002521.2; -.
UniGene Hs.410969
3D structure databases
PDB
1WWC; X-ray; 1.90 A; A=297-401.[ExPASy / RCSB / EBI]
PDBsum 1WWC; -.
ModBase Q16288.
Protein-protein interaction databases
DIP DIP:5723N; -.
PTM databases
PhosphoSite Q16288; -.
Organism-specific databases
H-InvDB HIX0012549; -.
HGNC HGNC:8033; NTRK3.
GeneLynx NTRK3; Homo sapiens.
GenAtlas NTRK3.
HPA CAB009233; -.
MIM 191316; gene. [NCBI / EBI]
PharmGKB PA31819; -.
GeneCards Q16288.
Gene expression databases
ArrayExpress Q16288; -.
CleanEx HS_NTRK3; -.
GermOnline ENSG00000140538; Homo sapiens.
Ontologies
GO
GO:0005887; Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0043121; Molecular function: neurotrophin binding (traceable author statement from ProtInc).
GO:0007169; Biological process: transmembrane receptor protein tyrosine kinase signaling pathway (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR013151; Ig.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR001611; LRR.
IPR000483; LRR_C.
IPR000372; LRR_cys_N.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR002011; Recept_tyr_kinase-II_CS.
IPR001245; Tyr_pkinase.
IPR008266; Tyr_pkinase_AS.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.10; Ig-like_fold; 2.
Pfam PF07679; I-set; 1.
PF00047; ig; 1.
PF00560; LRR_1; 1.
PF01462; LRRNT; 1.
PF07714; Pkinase_Tyr; 1.
Pfam graphical view of domain structure.
PRINTS PR00109; TYRKINASE.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00409; IG; 1.
SM00082; LRRCT; 1.
SM00013; LRRNT; 1.
SM00219; TyrKc; 1.
SMART graphical view of domain structure.
PROSITE PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q16288.
Genome annotation databases
Ensembl ENSG00000140538; Homo sapiens. [Contig view]
GeneID 4916; -.
Phylogenomic databases
HOGENOM Q16288; -.
HOVERGEN Q16288; -.
Other
SOURCE NTRK3; Homo sapiens.
ProtoNet Q16288.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Alternative splicing; ATP-binding; Developmental protein; Differentiation; Direct protein sequencing; Glycoprotein; Immunoglobulin domain; Kinase; Leucine-rich repeat; Membrane; Neurogenesis; Nucleotide-binding; Phosphoprotein; Polymorphism; Receptor; Repeat; Signal; Transferase; Transmembrane; Tyrosine-protein kinase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    31  31      
CHAIN   32   839  808     NT-3 growth factor receptor. PRO_0000016731
TOPO_DOM   32   429  398     Extracellular (Potential). 
TRANSMEM   430   453  24     Potential. 
TOPO_DOM   454   839  386     Cytoplasmic (Potential). 
REPEAT   102   125  24     LRR 1. 
REPEAT   126   149  24     LRR 2. 
DOMAIN   210   300  91     Ig-like C2-type 1. 
DOMAIN   309   382  74     Ig-like C2-type 2. 
DOMAIN   538   839  302     Protein kinase. 
NP_BIND   544   552  9     ATP (By similarity). 
ACT_SITE   679   679        Proton acceptor (By similarity). 
BINDING   572   572        ATP (By similarity). 
SITE   516   516  1     Interaction with SHC1 (By similarity). 
SITE   834   834  1     Interaction with PLC-gamma-1 (By similarity). 
MOD_RES   516   516        Phosphotyrosine; by autocatalysis (By similarity). 
MOD_RES   705   705        Phosphotyrosine; by autocatalysis (By similarity). 
MOD_RES   709   709        Phosphotyrosine; by autocatalysis (By similarity). 
MOD_RES   710   710        Phosphotyrosine; by autocatalysis (By similarity). 
MOD_RES   834   834        Phosphotyrosine (By similarity). 
CARBOHYD   72    72        N-linked (GlcNAc...) (Potential). 
CARBOHYD   79    79        N-linked (GlcNAc...) (Potential). 
CARBOHYD   133   133        N-linked (GlcNAc...) (Potential). 
CARBOHYD   163   163        N-linked (GlcNAc...) (Potential). 
CARBOHYD   203   203        N-linked (GlcNAc...) (Potential). 
CARBOHYD   218   218        N-linked (GlcNAc...) (Potential). 
CARBOHYD   232   232        N-linked (GlcNAc...) (Potential). 
CARBOHYD   259   259        N-linked (GlcNAc...) (Potential). 
CARBOHYD   267   267        N-linked (GlcNAc...) (Potential). 
CARBOHYD   272   272        N-linked (GlcNAc...) (Potential). 
CARBOHYD   294   294        N-linked (GlcNAc...) (Potential). 
CARBOHYD   375   375        N-linked (GlcNAc...) (Potential). 
CARBOHYD   388   388        N-linked (GlcNAc...) (Potential). 
DISULFID   320   362         
VAR_SEQ   402   410        Missing (in isoform D). VSP_002924
VAR_SEQ   529   612        YVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKML VAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVC GDGDP -> WVFSNIDNHGILNLKDNRDHLVPSTHYIYEEPEVQSGEVS YPRSHGFREIMLNPISLPGHSKPLNHGIYVEDVNVYFSK GRHGF (in isoform B). VSP_002925
VAR_SEQ   613   839        Missing (in isoform B). VSP_002926
VAR_SEQ   712   725        Missing (in isoform C). VSP_002927
VARIANT   149   149  1     T -> R (in a gastric adenocarcinoma sample; somatic mutation). VAR_041471 
VARIANT   306   306  1     R -> C. VAR_041472 [3D]
VARIANT   307   307  1     V -> L (in a lung adenocarcinoma sample; somatic mutation). VAR_041473 [3D]
VARIANT   336   336  1     L -> Q (in a lung adenocarcinoma sample; somatic mutation). VAR_041474 [3D]
VARIANT   677   677  1     H -> Y (in a lung adenocarcinoma sample; somatic mutation). VAR_041475 
VARIANT   678   678  1     R -> Q. VAR_041476 
CONFLICT   70    70        S -> N (in Ref. 2; AAB33111/AAB33112). 
CONFLICT   635   635        D -> N (in Ref. 1; AAA75374). 
STRAND   303   310  8      
STRAND   314   329  16      
STRAND   332   337  6      
STRAND   345   354  10      
STRAND   356   367  12      
HELIX   370   372  3      
STRAND   374   382  9      
STRAND   385   393  9      
Sequence information
Length: 839 AA [This is the length of the unprocessed precursor] Molecular weight: 94428 Da [This is the MW of the unprocessed precursor] CRC64: 7FE8846830083C08 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEINCRRPDD GNLFPLLEGQ 

        70         80         90        100        110        120 
DSGNSNGNAS INITDISRNI TSIHIENWRS LHTLNAVDME LYTGLQKLTI KNSGLRSIQP 

       130        140        150        160        170        180 
RAFAKNPHLR YINLSSNRLT TLSWQLFQTL SLRELQLEQN FFNCSCDIRW MQLWQEQGEA 

       190        200        210        220        230        240 
KLNSQNLYCI NADGSQLPLF RMNISQCDLP EISVSHVNLT VREGDNAVIT CNGSGSPLPD 

       250        260        270        280        290        300 
VDWIVTGLQS INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT 

       310        320        330        340        350        360 
VYYPPRVVSL EEPELRLEHC IEFVVRGNPP PTLHWLHNGQ PLRESKIIHV EYYQEGEISE 

       370        380        390        400        410        420 
GCLLFNKPTH YNNGNYTLIA KNPLGTANQT INGHFLKEPF PESTDNFILF DEVSPTPPIT 

       430        440        450        460        470        480 
VTHKPEEDTF GVSIAVGLAA FACVLLVVLF VMINKYGRRS KFGMKGPVAV ISGEEDSASP 

       490        500        510        520        530        540 
LHHINHGITT PSSLDAGPDT VVIGMTRIPV IENPQYFRQG HNCHKPDTYV QHIKRRDIVL 

       550        560        570        580        590        600 
KRELGEGAFG KVFLAECYNL SPTKDKMLVA VKALKDPTLA ARKDFQREAE LLTNLQHEHI 

       610        620        630        640        650        660 
VKFYGVCGDG DPLIMVFEYM KHGDLNKFLR AHGPDAMILV DGQPRQAKGE LGLSQMLHIA 

       670        680        690        700        710        720 
SQIASGMVYL ASQHFVHRDL ATRNCLVGAN LLVKIGDFGM SRDVYSTDYY RLFNPSGNDF 

       730        740        750        760        770        780 
CIWCEVGGHT MLPIRWMPPE SIMYRKFTTE SDVWSFGVIL WEIFTYGKQP WFQLSNTEVI 

       790        800        810        820        830 
ECITQGRVLE RPRVCPKEVY DVMLGCWQRE PQQRLNIKEI YKILHALGKA TPIYLDILG 

Q16288 in FASTA format

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