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UniProtKB/Swiss-Prot entry Q13009


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TIAM1_HUMAN
Primary accession number Q13009
Secondary accession number Q17RT7
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on July 10, 2007 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 83)
Name and origin of the protein
Protein name T-lymphoma invasion and metastasis-inducing protein 1
Synonym TIAM-1
Gene name
Name: TIAM1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT HIS-844.
TISSUE=Fetal brain;
PubMed=7731688 [NCBI, ExPASy, EBI, Israel, Japan]
Habets G.G.M., van der Kammen R.A., Stam J.C., Michiels F., Collard J.G.;
"Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin.";
Oncogene 10:1371-1376(1995).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/35012518; PubMed=10830953 [NCBI, ExPASy, EBI, Israel, Japan]
Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
"The DNA sequence of human chromosome 21.";
Nature 405:311-319(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
INTERACTION WITH RAC.
TISSUE=Brain;
DOI=10.1038/375338a0; PubMed=7753201 [NCBI, ExPASy, EBI, Israel, Japan]
Michiels F., Habets G.G.M., Stam J.C., van der Kammen R.A., Collard J.G.;
"A role for Rac in Tiam1-induced membrane ruffling and invasion.";
Nature 375:338-340(1995).
[5]
MAPPING.
PubMed=7736788 [NCBI, ExPASy, EBI, Israel, Japan]
Habets G.G.M., van der Kammen R.A., Jenkins N.A., Gilbert D.J., Copeland N.G., Hagemeijer A., Collard J.G.;
"The invasion-inducing TIAM1 gene maps to human chromosome band 21q22 and mouse chromosome 16.";
Cytogenet. Cell Genet. 70:48-51(1995).
[6]
INTERACTION WITH BAIAP2.
DOI=10.1128/MCB.25.11.4602-4614.2005; PubMed=15899863 [NCBI, ExPASy, EBI, Israel, Japan]
Connolly B.A., Rice J., Feig L.A., Buchsbaum R.J.;
"Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation.";
Mol. Cell. Biol. 25:4602-4614(2005).
[7]
STRUCTURE BY NMR OF 835-935.
RIKEN structural genomics initiative (RSGI);
"Solution structure of the PDZ domain of T-cell lymphoma invasion and metastasis 1 variant.";
Submitted (JUN-2006) to the PDB data bank.
[8]
VARIANTS [LARGE SCALE ANALYSIS] CYS-678 AND VAL-1339.
DOI=10.1126/science.1133427; PubMed=16959974 [NCBI, ExPASy, EBI, Israel, Japan]
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal cancers.";
Science 314:268-274(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U16296; AAA98443.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AP000246; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AP000247; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
BC117192; AAI17193.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC117196; AAI17197.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00011400; -.
RefSeq NP_003244.2; -.
UniGene Hs.517228
3D structure databases
PDB
2D8I; NMR; -; A=835-935.[ExPASy / RCSB / EBI]
PDBsum 2D8I; -.
SMR Q13009; 1034-1401.
ModBase Q13009.
Protein-protein interaction databases
IntAct Q13009; 6.
PTM databases
PhosphoSite Q13009; -.
Enzyme and pathway databases
Pathway_Interaction_DB arf6downstreampathway; Arf6 downstream pathway.
pi3kcipathway; Class I PI3K signaling events.
epha2_fwdpathway; EPHA2 forward signaling.
ephrinbrevpathway; Ephrin B reverse signaling.
lysophospholipid_pathway; LPA receptor mediated events.
trkrpathway; Neurotrophic factor-mediated Trk receptor signaling.
Reactome REACT_11044; Signaling by Rho GTPases.
Organism-specific databases
GeneCards GC21M031414; -.
H-InvDB HIX0016054; -.
HGNC HGNC:11805; TIAM1.
GenAtlas TIAM1.
HPA CAB010416; -.
MIM 600687; gene. [NCBI / EBI]
PharmGKB PA36514; -.
Gene expression databases
ArrayExpress Q13009; -.
Bgee Q13009; -.
CleanEx HS_TIAM1; -.
GermOnline ENSG00000156299; Homo sapiens.
Ontologies
GO
GO:0005622; Cellular component: intracellular (inferred from electronic annotation from InterPro).
GO:0005057; Molecular function: receptor signaling protein activity (inferred from electronic annotation from InterPro).
GO:0005089; Molecular function: Rho guanyl-nucleotide exchange factor activity (traceable author statement from ProtInc).
GO:0035023; Biological process: regulation of Rho protein signal transduction (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000219; DH-domain.
IPR001331; GDS_CDC24_CS.
IPR001478; PDZ/DHR/GLGF.
IPR011993; PH_type.
IPR001849; Pleckstrin_homology.
IPR003116; Raf-like_ras_bd.
Graphical view of domain structure.
Gene3D G3DSA:2.30.29.30; PH_type; 1.
Pfam PF00595; PDZ; 1.
PF00169; PH; 2.
PF02196; RBD; 1.
PF00621; RhoGEF; 1.
Pfam graphical view of domain structure.
SMART SM00228; PDZ; 1.
SM00233; PH; 2.
SM00455; RBD; 1.
SM00325; RhoGEF; 1.
SMART graphical view of domain structure.
PROSITE PS00741; DH_1; 1.
PS50010; DH_2; 1.
PS50106; PDZ; 1.
PS50003; PH_DOMAIN; 1.
PS50898; RBD; 1.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
Ensembl ENSG00000156299; Homo sapiens. [Contig view]
GeneID 7074; -.
KEGG hsa:7074; -.
NMPDR fig|9606.3.peg.20867; -.
Phylogenomic databases
HOGENOM Q13009; -.
HOVERGEN Q13009; -.
OMA Q13009; IHRNSEV.
Other
NextBio 27667; -.
SOURCE TIAM1; Homo sapiens.
ProtoNet Q13009.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Guanine-nucleotide releasing factor; Lipoprotein; Myristate; Phosphoprotein; Polymorphism; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
INIT_MET   1      1        Removed (Potential). 
CHAIN   2   1591  1590     T-lymphoma invasion and metastasis-inducing protein 1. PRO_0000080976
DOMAIN   434    549  116     PH 1. 
DOMAIN   765    832  68     RBD. 
DOMAIN   845    908  64     PDZ. 
DOMAIN   1040   1234  195     DH. 
DOMAIN   1261   1397  137     PH 2. 
COMPBIAS   595    598  4     Poly-Lys. 
COMPBIAS   1445   1449  5     Poly-Arg. 
MOD_RES   231    231        Phosphoserine (By similarity). 
MOD_RES   1323   1323        Phosphotyrosine (By similarity). 
LIPID   2      2        N-myristoyl glycine (Potential). 
VARIANT   247    247  1     G -> R (in dbSNP:rs2070418 [NCBI]). VAR_051991 
VARIANT   247    247  1     G -> V (in dbSNP:rs2070417 [NCBI]). VAR_051992 
VARIANT   678    678  1     R -> C (in a colorectal cancer sample; somatic mutation). VAR_035977 
VARIANT   844    844  1     Q -> H (in dbSNP:rs16987932 [NCBI]). VAR_051993 
VARIANT   1339   1339  1     A -> V (in a colorectal cancer sample; somatic mutation). VAR_035978 
CONFLICT   24     25        KH -> ND (in Ref. 1; AAA98443). 
CONFLICT   247    247        G -> M (in Ref. 1; AAA98443). 
CONFLICT   951    951        G -> D (in Ref. 1; AAA98443). 
CONFLICT   1018   1018        S -> N (in Ref. 1; AAA98443). 
CONFLICT   1040   1041        KL -> NV (in Ref. 1; AAA98443). 
CONFLICT   1148   1148        S -> I (in Ref. 1; AAA98443). 
STRAND   842    849  8      
TURN   853    855  3      
STRAND   861    867  7      
STRAND   870    877  8      
HELIX   884    887  4      
STRAND   895    900  6      
HELIX   903    905  3      
HELIX   908    915  8      
STRAND   917    926  10      
Sequence information
Length: 1591 AA [This is the length of the unprocessed precursor] Molecular weight: 177508 Da [This is the MW of the unprocessed precursor] CRC64: 0DAFBEE9A84B3452 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGNAESQHVE HEFYGEKHAS LGRKHTSRSL RLSHKTRRTR HASSGKVIHR NSEVSTRSSS 

        70         80         90        100        110        120 
TPSIPQSLAE NGLEPFSQDG TLEDFGSPIW VDRVDMGLRP VSYTDSSVTP SVDSSIVLTA 

       130        140        150        160        170        180 
ASVQSMPDTE ESRLYGDDAT YLAEGGRRQH SYTSNGPTFM ETASFKKKRS KSADIWREDS 

       190        200        210        220        230        240 
LEFSLSDLSQ EHLTSNEEIL GSAEEKDCEE ARGMETRASP RQLSTCQRAN SLGDLYAQKN 

       250        260        270        280        290        300 
SGVTANGGPG SKFAGYCRNL VSDIPNLANH KMPPAAAEET PPYSNYNTLP CRKSHCLSEG 

       310        320        330        340        350        360 
ATNPQISHSN SMQGRRAKTT QDVNAGEGSE FADSGIEGAT TDTDLLSRRS NATNSSYSPT 

       370        380        390        400        410        420 
TGRAFVGSDS GSSSTGDAAR QGVYENFRRE LEMSTTNSES LEEAGSAHSD EQSSGTLSSP 

       430        440        450        460        470        480 
GQSDILLTAA QGTVRKAGAL AVKNFLVHKK NKKVESATRR KWKHYWVSLK GCTLFFYESD 

       490        500        510        520        530        540 
GRSGIDHNSI PKHAVWVENS IVQAVPEHPK KDFVFCLSNS LGDAFLFQTT SQTELENWIT 

       550        560        570        580        590        600 
AIHSACATAV ARHHHKEDTL RLLKSEIKKL EQKIDMDEKM KKMGEMQLSS VTDSKKKKTI 

       610        620        630        640        650        660 
LDQIFVWEQN LEQFQMDLFR FRCYLASLQG GELPNPKRLL AFASRPTKVA MGRLGIFSVS 

       670        680        690        700        710        720 
SFHALVAART GETGVRRRTQ AMSRSASKRR SRFSSLWGLD TTSKKKQGRP SINQVFGEGT 

       730        740        750        760        770        780 
EAVKKSLEGI FDDIVPDGKR EKEVVLPNVH QHNPDCDIWV HEYFTPSWFC LPNNQPALTV 

       790        800        810        820        830        840 
VRPGDTARDT LELICKTHQL DHSAHYLRLK FLIENKMQLY VPQPEEDIYE LLYKEIEICP 

       850        860        870        880        890        900 
KVTQSIHIEK SDTAADTYGF SLSSVEEDGI RRLYVNSVKE TGLASKKGLK AGDEILEINN 

       910        920        930        940        950        960 
RAADALNSSM LKDFLSQPSL GLLVRTYPEL EEGVELLESP PHRVDGPADL GESPLAFLTS 

       970        980        990       1000       1010       1020 
NPGHSLCSEQ GSSAETAPEE TEGPDLESSD ETDHSSKSTE QVAAFCRSLH EMNPSDQSPS 

      1030       1040       1050       1060       1070       1080 
PQDSTGPQLA TMRQLSDADK LRKVICELLE TERTYVKDLN CLMERYLKPL QKETFLTQDE 

      1090       1100       1110       1120       1130       1140 
LDVLFGNLTE MVEFQVEFLK TLEDGVRLVP DLEKLEKVDQ FKKVLFSLGG SFLYYADRFK 

      1150       1160       1170       1180       1190       1200 
LYSAFCASHT KVPKVLVKAK TDTAFKAFLD AQNPKQQHSS TLESYLIKPI QRILKYPLLL 

      1210       1220       1230       1240       1250       1260 
RELFALTDAE SEEHYHLDVA IKTMNKVASH INEMQKIHEE FGAVFDQLIA EQTGEKKEVA 

      1270       1280       1290       1300       1310       1320 
DLSMGDLLLH TTVIWLNPPA SLGKWKKEPE LAAFVFKTAV VLVYKDGSKQ KKKLVGSHRL 

      1330       1340       1350       1360       1370       1380 
SIYEDWDPFR FRHMIPTEAL QVRALASADA EANAVCEIVH VKSESEGRPE RVFHLCCSSP 

      1390       1400       1410       1420       1430       1440 
ESRKDFLKAV HSILRDKHRR QLLKTESLPS SQQYVPFGGK RLCALKGARP AMSRAVSAPS 

      1450       1460       1470       1480       1490       1500 
KSLGRRRRRL ARNRFTIDSD AVSASSPEKE SQQPPGGGDT DRWVEEQFDL AQYEEQDDIK 

      1510       1520       1530       1540       1550       1560 
ETDILSDDDE FCESVKGASV DRDLQERLQA TSISQRERGR KTLDSHASRM AQLKKQAALS 

      1570       1580       1590 
GINGGLESAS EEVIWVRRED FAPSRKLNTE I 

Q13009 in FASTA format

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