[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION. STRAIN=SAS56; PubMed=11929539 [NCBI, ExPASy, EBI, Israel, Japan] Schouten A., Wagemakers L., Stefanato F.L., van der Kaaij R.M., van Kan J.A.L.; "Resveratrol acts as a natural profungicide and induces self-intoxication by a specific laccase."; Mol. Microbiol. 43:883-894(2002).
[2]	NUCLEOTIDE SEQUENCE [MRNA] OF 115-561. STRAIN=SAS56; Cantone F.A., Staples R.C.; "A laccase cDNA from Botrytis cinerea."; Phytopathology 83:1383-1383(1993).

Comments

FUNCTION: Lignin degradation and detoxification of lignin-derived products (By similarity).
CATALYTIC ACTIVITY: 4 benzenediol + O₂ = 4 benzosemiquinone + 2 H₂O.
COFACTOR: Binds 4 copper ions per monomer (By similarity).
SUBCELLULAR LOCATION: Secreted (Potential).
INDUCTION: Not induced by resveratrol or tannins.
SIMILARITY: Belongs to the multicopper oxidase family.
SIMILARITY: Contains 3 plastocyanin-like domains.
SEQUENCE CAUTION:
- Sequence=AAB41823.1; Type=Erroneous gene model prediction; Note=The sequence does probably not originate from mRNA or it was not properly spliced

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF243854; AAK77952.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U20192; AAB41823.1; ALT_SEQ; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

Q9Y780; 1HFU. [HSSP ENTRY / PDB]

ModBase

Q12570.

Ontologies

GO:0005576;	Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
GO:0008471;	Molecular function: laccase activity (inferred from electronic annotation from EC).
GO:0046274;	Biological process: lignin catabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001117; Cu-oxidase.
IPR011706; Cu-oxidase_2.
IPR011707; Cu-oxidase_3.
IPR002355; Cu_oxidase_Cu_BS.
Graphical view of domain structure.

Pfam

PF00394; Cu-oxidase; 1.
PF07731; Cu-oxidase_2; 1.
PF07732; Cu-oxidase_3; 1.
Pfam graphical view of domain structure.

PROSITE

PS00079; MULTICOPPER_OXIDASE1; 1.
PS00080; MULTICOPPER_OXIDASE2; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Copper; Glycoprotein; Lignin degradation; Metal-binding; Oxidoreductase; Repeat; Secreted; Signal.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 20`	`20`	`Potential.`
`CHAIN`	`21 561`	`541`	`Laccase-1.`	`PRO_0000085584`
`DOMAIN`	`68 185`	`118`	`Plastocyanin-like 1.`
`DOMAIN`	`191 337`	`147`	`Plastocyanin-like 2.`
`DOMAIN`	`396 525`	`130`	`Plastocyanin-like 3.`
`METAL`	`119 119`		`Copper 1; type 2 (By similarity).`
`METAL`	`121 121`		`Copper 2; type 3 (By similarity).`
`METAL`	`163 163`		`Copper 2; type 3 (By similarity).`
`METAL`	`165 165`		`Copper 3; type 3 (By similarity).`
`METAL`	`445 445`		`Copper 4; type 1 (By similarity).`
`METAL`	`448 448`		`Copper 1; type 2 (By similarity).`
`METAL`	`450 450`		`Copper 3; type 3 (By similarity).`
`METAL`	`504 504`		`Copper 3; type 3 (By similarity).`
`METAL`	`505 505`		`Copper 4; type 1 (By similarity).`
`METAL`	`506 506`		`Copper 2; type 3 (By similarity).`
`METAL`	`510 510`		`Copper 4; type 1 (By similarity).`
`CARBOHYD`	`71 71`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`87 87`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`114 114`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`226 226`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`284 284`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`327 327`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`391 391`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`398 398`		`N-linked (GlcNAc...) (Potential).`
`CONFLICT`	`117 118`		`SI -> TM (in Ref. 2; AAB41823).`
`CONFLICT`	`372 372`		`V -> I (in Ref. 2; AAB41823).`
`CONFLICT`	`429 429`		`N -> K (in Ref. 2; AAB41823).`
`CONFLICT`	`481 481`		`M -> L (in Ref. 2; AAB41823).`
`CONFLICT`	`484 484`		`P -> S (in Ref. 2; AAB41823).`
`CONFLICT`	`511 511`		`A -> V (in Ref. 2; AAB41823).`
`CONFLICT`	`547 547`		`A -> G (in Ref. 2; AAB41823).`

Sequence information

Length: 561 AA [This is the length of the unprocessed precursor]

Molecular weight: 60337 Da [This is the MW of the unprocessed precursor]

CRC64: 7F366B289EF73C23 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKNSFFSSLA KFASLSLAFA LPTAEVIPSA LEERQSCANT ATTRSCWGQY SASTNSYTTV 

        70         80         90        100        110        120 
PKTGYWLVVQ NTTLSADGVS RPTLNFNGTI PGPQITADWG DDVIVHVTNK LTSNGTSIHW 

       130        140        150        160        170        180 
HGIRQLNNAQ YDGVPGITQC PIAPGGTLTY KFHADNYGSS WYHSHFILQY GDGLFGPLVI 

       190        200        210        220        230        240 
NGPATANYDV DLGMLFLNDW NHVPVQSLWD KAKTGAPPTL LTGLMNGTNT YNGAGKKFQT 

       250        260        270        280        290        300 
TFTPGLKYRI RVVNTAVDGH FQFSIDGHSF QVIAMDFVPI VPYNATSILV SIAQRYDIIV 

       310        320        330        340        350        360 
TANAAVGNYW IRAGWQTACS GNTNAANITG ILRYTGSSST ADPTTTSTVT ASTSCLDEPL 

       370        380        390        400        410        420 
ASLVPFVPIN PVASSIMKTT LTTGGGQWLF NGSSLLLNWT DPTLLTVLNS GNIWPTEYNV 

       430        440        450        460        470        480 
IPIESTTANK GWAVLAISGP NGPNHPIHLH GHDFWTLSQG TGAYTATTAL NLVNPPRRDV 

       490        500        510        520        530        540 
MTLPTGGHLV IAFQIDNPGS WLMHCHIAWH ASEGLALQFV ESESSILPTI GTADVSTFQN 

       550        560 
TCAAWKAWTP TEPFPQDDSG I

Q12570 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools