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UniProtKB/Swiss-Prot entry Q10567

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AP1B1_HUMAN
Primary accession number Q10567
Secondary accession number P78436
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on October 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 68)
Name and origin of the protein
Protein name AP-1 complex subunit beta-1
Synonyms Adapter-related protein complex 1 subunit beta-1
Adaptor protein complex AP-1 subunit beta-1
Beta-adaptin 1
Beta1-adaptin
Golgi adaptor HA1/AP1 adaptin beta subunit
Clathrin assembly protein complex 1 beta large chain
Gene name
Name: AP1B1
Synonyms: ADTB1, BAM22, CLAPB2
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
TISSUE=Brain;
DOI=10.1093/hmg/3.8.1393; PubMed=7987321 [NCBI, ExPASy, EBI, Israel, Japan]
Peyrard M., Fransson I., Xie Y.-G., Han F.-Y., Ruttledge M.H., Swahn S., Collins J.E., Dunham I., Collins V.P., Dumanski J.P.;
"Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene.";
Hum. Mol. Genet. 3:1393-1399(1994).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-922.
DOI=10.1006/geno.1996.0431; PubMed=8812422 [NCBI, ExPASy, EBI, Israel, Japan]
Peyrard M., Pan H.-Q., Kedra D., Fransson I., Swahn S., Hartman K., Clifton S.W., Roe B.A., Dumanski J.P.;
"Structure of the promoter and genomic organization of the human beta'-adaptin gene (BAM22) from chromosome 22q12.";
Genomics 36:112-117(1996).
Comments
  • FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
  • SUBUNIT: Adaptor protein complex 1 (AP-1) is an heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).
  • SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
  • ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing.
    NameA
    Isoform IDQ10567-1
    This is the isoform sequence displayed in this entry.
    NameB
    Isoform IDQ10567-2
    Features which should be applied to build the isoform sequence: VSP_000163.
  • TISSUE SPECIFICITY: Widely expressed.
  • DISEASE: Deletion of the AP1B1 gene may play a role in the tumorigenesis of meningiomas.
  • SIMILARITY: Belongs to the adaptor complexes large subunit family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L13939; AAC98702.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U36268; AAC50684.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U36250; AAC50684.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U36251; AAC50684.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U36252; AAC50684.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U36253; AAC50684.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U36254; AAC50684.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U36255; AAC50684.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U36256; AAC50684.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U36257; AAC50684.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U36258; AAC50684.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U36259; AAC50684.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U36260; AAC50684.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U36261; AAC50684.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U36262; AAC50684.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U36263; AAC50684.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U36264; AAC50684.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U36265; AAC50684.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U36266; AAC50684.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U36267; AAC50684.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF379038; AAC50684.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF379039; AAC50684.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L48038; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
PIR I54360; I54360.
RefSeq NP_001118.2; -.
NP_663782.1; -.
UniGene Hs.368794
3D structure databases
HSSP P21851; 1GW5. [HSSP ENTRY / PDB]
SMR Q10567; 714-949.
ModBase Q10567.
Protein-protein interaction databases
DIP DIP:24207N; -.
IntAct Q10567; -.
PTM databases
PhosphoSite Q10567; -.
Enzyme and pathway databases
Reactome REACT_6185; HIV Infection.
Organism-specific databases
H-InvDB HIX0027860; -.
HGNC HGNC:554; AP1B1.
GenAtlas AP1B1.
MIM 600157; gene. [NCBI / EBI]
PharmGKB PA24844; -.
GeneCards Q10567.
Gene expression databases
ArrayExpress Q10567; -.
CleanEx HS_AP1B1; -.
GermOnline ENSG00000100280; Homo sapiens.
Ontologies
GO
GO:0005829; Cellular component: cytosol (inferred from experiment from Reactome).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from UniProtKB).
GO:0005215; Molecular function: transporter activity (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR016342; AP_complex_bsu.
IPR012295; b_Adaptin_TBP_C.
IPR002553; Clathrin/coatomer_adapt-like_N.
IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
IPR013037; Clathrin_b-adaptin_app_Ig-like.
IPR015151; Clathrin_b-adaptin_app_sub_C.
Graphical view of domain structure.
Gene3D G3DSA:3.30.310.10; b_Adaptin_TBP_C; 1.
G3DSA:2.60.40.1150; Clathrin_b-adaptin_app_Ig-like; 1.
Pfam PF01602; Adaptin_N; 1.
PF02883; Alpha_adaptinC2; 1.
PF09066; B2-adapt-app_C; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF002291; AP_complex_beta; 1.
SMART SM00809; Alpha_adaptinC2; 1.
SMART graphical view of domain structure.
BLOCKS Q10567.
Genome annotation databases
Ensembl ENSG00000100280; Homo sapiens. [Contig view]
GeneID 162; -.
KEGG hsa:162; -.
Phylogenomic databases
HOGENOM Q10567; -.
HOVERGEN Q10567; -.
Other
LinkHub Q10567; -.
SOURCE AP1B1; Homo sapiens.
ProtoNet Q10567.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Cytoplasmic vesicle; Endocytosis; Golgi apparatus; Membrane; Protein transport; Transport.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   949  949     AP-1 complex subunit beta-1. PRO_0000193738
COMPBIAS   576   725  150     Pro-rich (stalk region). 
VAR_SEQ   667   673        Missing (in isoform B). VSP_000163
Sequence information
Length: 949 AA [This is the length of the unprocessed precursor] Molecular weight: 104607 Da [This is the MW of the unprocessed precursor] CRC64: 0B010DD2F29B248E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTDSKYFTTT KKGEIFELKA ELNSDKKEKK KEAVKKVIAS MTVGKDVSAL FPDVVNCMQT 

        70         80         90        100        110        120 
DNLELKKLVY LYLMNYAKSQ PDMAIMAVNT FVKDCEDPNP LIRALAVRTM GCIRVDKITE 

       130        140        150        160        170        180 
YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD INAQLVEDQG FLDTLKDLIS DSNPMVVANA 

       190        200        210        220        230        240 
VAALSEIAES HPSSNLLDLN PQSINKLLTA LNECTEWGQI FILDCLANYM PKDDREAQSI 

       250        260        270        280        290        300 
CERVTPRLSH ANSAVVLSAV KVLMKFMEML SKDLDYYGTL LKKLAPPLVT LLSAEPELQY 

       310        320        330        340        350        360 
VALRNINLIV QKRPEILKHE MKVFFVKYND PIYVKLEKLD IMIRLASQAN IAQVLAELKE 

       370        380        390        400        410        420 
YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ TKVNYVVQEA IVVIKDIFRK 

       430        440        450        460        470        480 
YPNKYESVIA TLCENLDSLD EPEARAAMIW IVGEYAERID NADELLESFL EGFHDESTQV 

       490        500        510        520        530        540 
QLQLLTAIVK LFLKKPTETQ ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVAAKEV 

       550        560        570        580        590        600 
VLAEKPLISE ETDLIEPTLL DELICYIGTL ASVYHKPPSA FVEGGRGVVH KSLPPRTASS 

       610        620        630        640        650        660 
ESAESPETAP TGAPPGEQPD VIPAQGDLLG DLLNLDLGPP VSGPPLATSS VQMGAVDLLG 

       670        680        690        700        710        720 
GGLDSLMGDE PEGIGGTNFV APPTAAVPAN LGAPIGSGLS DLFDLTSGVG TLSGSYVAPK 

       730        740        750        760        770        780 
AVWLPAMKAK GLEISGTFTR QVGSISMDLQ LTNKALQVMT DFAIQFNRNS FGLAPAAPLQ 

       790        800        810        820        830        840 
VHAPLSPNQT VEISLPLSTV GSVMKMEPLN NLQVAVKNNI DVFYFSTLYP LHILFVEDGK 

       850        860        870        880        890        900 
MDRQMFLATW KDIPNENEAQ FQIRDCPLNA EAASSKLQSS NIFTVAKRNV EGQDMLYQSL 

       910        920        930        940 
KLTNGIWVLA ELRIQPGNPS CTDLELSLKC RAPEVSQHVY QAYETILKN
Q10567 in FASTA format

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View entry in raw text format (no links)
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