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[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
TISSUE=Brain;
DOI=10.1093/hmg/3.8.1393; PubMed=7987321 [NCBI, ExPASy, EBI, Israel, Japan]
Peyrard M.,
Fransson I.,
Xie Y.-G.,
Han F.-Y.,
Ruttledge M.H.,
Swahn S.,
Collins J.E.,
Dunham I.,
Collins V.P.,
Dumanski J.P.;
"Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene.";
Hum. Mol. Genet. 3:1393-1399(1994).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-922.
DOI=10.1006/geno.1996.0431; PubMed=8812422 [NCBI, ExPASy, EBI, Israel, Japan]
Peyrard M.,
Pan H.-Q.,
Kedra D.,
Fransson I.,
Swahn S.,
Hartman K.,
Clifton S.W.,
Roe B.A.,
Dumanski J.P.;
"Structure of the promoter and genomic organization of the human beta'-adaptin gene (BAM22) from chromosome 22q12.";
Genomics 36:112-117(1996).
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[3]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-897, AND MASS SPECTROMETRY.
TISSUE=Lung;
DOI=10.1016/j.cell.2007.11.025; PubMed=18083107 [NCBI, ExPASy, EBI, Israel, Japan]
Rikova K.,
Guo A.,
Zeng Q.,
Possemato A.,
Yu J.,
Haack H.,
Nardone J.,
Lee K.,
Reeves C.,
Li Y.,
Hu Y.,
Tan Z.,
Stokes M.,
Sullivan L.,
Mitchell J.,
Wetzel R.,
Macneill J.,
Ren J.M.,
Yuan J., ![]()
Bakalarski C.E.,
Villen J.,
Kornhauser J.M.,
Smith B.,
Li D.,
Zhou X.,
Gygi S.P.,
Gu T.-L.,
Polakiewicz R.D.,
Rush J.,
Comb M.J.;
"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.";
Cell 131:1190-1203(2007).
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[4]
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IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J.,
Superti-Furga G.,
Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
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- FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
- SUBUNIT: Adaptor protein complex 1 (AP-1) is an heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).
- SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
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| Name | B |
| Isoform ID | Q10567-2 |
| Features which should be applied to build the isoform sequence: VSP_000163. |
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- TISSUE SPECIFICITY: Widely expressed.
- DISEASE: Deletion of the AP1B1 gene may play a role in the tumorigenesis of meningiomas.
- SIMILARITY: Belongs to the adaptor complexes large subunit family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 949 AA [This is the length of the unprocessed precursor] |
Molecular weight: 104607 Da [This is the MW of the unprocessed precursor] |
CRC64: 0B010DD2F29B248E [This is a checksum on the sequence] |
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10 20 30 40 50 60
MTDSKYFTTT KKGEIFELKA ELNSDKKEKK KEAVKKVIAS MTVGKDVSAL FPDVVNCMQT
70 80 90 100 110 120
DNLELKKLVY LYLMNYAKSQ PDMAIMAVNT FVKDCEDPNP LIRALAVRTM GCIRVDKITE
130 140 150 160 170 180
YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD INAQLVEDQG FLDTLKDLIS DSNPMVVANA
190 200 210 220 230 240
VAALSEIAES HPSSNLLDLN PQSINKLLTA LNECTEWGQI FILDCLANYM PKDDREAQSI
250 260 270 280 290 300
CERVTPRLSH ANSAVVLSAV KVLMKFMEML SKDLDYYGTL LKKLAPPLVT LLSAEPELQY
310 320 330 340 350 360
VALRNINLIV QKRPEILKHE MKVFFVKYND PIYVKLEKLD IMIRLASQAN IAQVLAELKE
370 380 390 400 410 420
YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ TKVNYVVQEA IVVIKDIFRK
430 440 450 460 470 480
YPNKYESVIA TLCENLDSLD EPEARAAMIW IVGEYAERID NADELLESFL EGFHDESTQV
490 500 510 520 530 540
QLQLLTAIVK LFLKKPTETQ ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVAAKEV
550 560 570 580 590 600
VLAEKPLISE ETDLIEPTLL DELICYIGTL ASVYHKPPSA FVEGGRGVVH KSLPPRTASS
610 620 630 640 650 660
ESAESPETAP TGAPPGEQPD VIPAQGDLLG DLLNLDLGPP VSGPPLATSS VQMGAVDLLG
670 680 690 700 710 720
GGLDSLMGDE PEGIGGTNFV APPTAAVPAN LGAPIGSGLS DLFDLTSGVG TLSGSYVAPK
730 740 750 760 770 780
AVWLPAMKAK GLEISGTFTR QVGSISMDLQ LTNKALQVMT DFAIQFNRNS FGLAPAAPLQ
790 800 810 820 830 840
VHAPLSPNQT VEISLPLSTV GSVMKMEPLN NLQVAVKNNI DVFYFSTLYP LHILFVEDGK
850 860 870 880 890 900
MDRQMFLATW KDIPNENEAQ FQIRDCPLNA EAASSKLQSS NIFTVAKRNV EGQDMLYQSL
910 920 930 940
KLTNGIWVLA ELRIQPGNPS CTDLELSLKC RAPEVSQHVY QAYETILKN
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Q10567 in FASTA format |
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