[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT ASP-173.
TISSUE=Myeloid leukemia cell;
DOI=10.1073/pnas.90.8.3516; PubMed=7682708 [NCBI, ExPASy, EBI, Israel, Japan]
Kozopas K.M.,
Yang T.,
Buchan H.L.,
Zhou P.,
Craig R.W.;
"MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.";
Proc. Natl. Acad. Sci. U.S.A. 90:3516-3520(1993).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND INDUCTION.
PubMed=8790944 [NCBI, ExPASy, EBI, Israel, Japan]
Umezawa A.,
Maruyama T.,
Inazawa J.,
Imai S.,
Takano T.,
Hata J.;
"Induction of mcl1/EAT, Bcl-2 related gene, by retinoic acid or heat shock in the human embryonal carcinoma cells, NCR-G3.";
Cell Struct. Funct. 21:143-150(1996).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
DOI=10.1007/PL00000728; PubMed=11130466 [NCBI, ExPASy, EBI, Israel, Japan]
Akgul C.,
Turner P.C.,
White M.R.H.,
Edwards S.W.;
"Functional analysis of the human MCL-1 gene.";
Cell. Mol. Life Sci. 57:684-691(2000).
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[4]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2), VARIANT ASP-173, AND FUNCTION.
TISSUE=Myeloid leukemia cell, and Neuroblastoma;
DOI=10.1074/jbc.M909572199; PubMed=10766760 [NCBI, ExPASy, EBI, Israel, Japan]
Bingle C.D.,
Craig R.W.,
Swales B.M.,
Singleton V.,
Zhou P.,
Whyte M.K.B.;
"Exon skipping in Mcl-1 results in a Bcl-2 homology domain 3 only gene product that promotes cell death.";
J. Biol. Chem. 275:22136-22146(2000).
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[5]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND INTERACTION WITH BAX; BAK1; BCL2L11 AND BETWEEN ISOFORMS 1 AND 2.
DOI=10.1074/jbc.M909826199; PubMed=10837489 [NCBI, ExPASy, EBI, Israel, Japan]
Bae J.,
Leo C.P.,
Hsu S.Y.,
Hsueh A.J.W.;
"MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain.";
J. Biol. Chem. 275:25255-25261(2000).
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[6]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Kalnine N.,
Chen X.,
Rolfs A.,
Halleck A.,
Hines L.,
Eisenstein S.,
Koundinya M.,
Raphael J.,
Moreira D.,
Kelley T.,
LaBaer J.,
Lin Y.,
Phelan M.,
Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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[7]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT VAL-227.
TISSUE=Thalamus;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T.,
Suzuki Y.,
Nishikawa T.,
Otsuki T.,
Sugiyama T.,
Irie R.,
Wakamatsu A.,
Hayashi K.,
Sato H.,
Nagai K.,
Kimura K.,
Makita H.,
Sekine M.,
Obayashi M.,
Nishi T.,
Shibahara T.,
Tanaka T.,
Ishii S.,
Yamamoto J., ![]()
Saito K.,
Kawai Y.,
Isono Y.,
Nakamura Y.,
Nagahari K.,
Murakami K.,
Yasuda T.,
Iwayanagi T.,
Wagatsuma M.,
Shiratori A.,
Sudo H.,
Hosoiri T.,
Kaku Y.,
Kodaira H.,
Kondo H.,
Sugawara M.,
Takahashi M.,
Kanda K.,
Yokoi T.,
Furuya T.,
Kikkawa E.,
Omura Y.,
Abe K.,
Kamihara K.,
Katsuta N.,
Sato K.,
Tanikawa M.,
Yamazaki M.,
Ninomiya K.,
Ishibashi T.,
Yamashita H.,
Murakawa K.,
Fujimori K.,
Tanai H.,
Kimata M.,
Watanabe M.,
Hiraoka S.,
Chiba Y.,
Ishida S.,
Ono Y.,
Takiguchi S.,
Watanabe S.,
Yosida M.,
Hotuta T.,
Kusano J.,
Kanehori K.,
Takahashi-Fujii A.,
Hara H.,
Tanase T.-O.,
Nomura Y.,
Togiya S.,
Komai F.,
Hara R.,
Takeuchi K.,
Arita M.,
Imose N.,
Musashino K.,
Yuuki H.,
Oshima A.,
Sasaki N.,
Aotsuka S.,
Yoshikawa Y.,
Matsunawa H.,
Ichihara T.,
Shiohata N.,
Sano S.,
Moriya S.,
Momiyama H.,
Satoh N.,
Takami S.,
Terashima Y.,
Suzuki O.,
Nakagawa S.,
Senoh A.,
Mizoguchi H.,
Goto Y.,
Shimizu F.,
Wakebe H.,
Hishigaki H.,
Watanabe T.,
Sugiyama A.,
Takemoto M.,
Kawakami B.,
Yamazaki M.,
Watanabe K.,
Kumagai A.,
Itakura S.,
Fukuzumi Y.,
Fujimori Y.,
Komiyama M.,
Tashiro H.,
Tanigami A.,
Fujiwara T.,
Ono T.,
Yamada K.,
Fujii Y.,
Ozaki K.,
Hirao M.,
Ohmori Y.,
Kawabata A.,
Hikiji T.,
Kobatake N.,
Inagaki H.,
Ikema Y.,
Okamoto S.,
Okitani R.,
Kawakami T.,
Noguchi S.,
Itoh T.,
Shigeta K.,
Senba T.,
Matsumura K.,
Nakajima Y.,
Mizuno T.,
Morinaga M.,
Sasaki M.,
Togashi T.,
Oyama M.,
Hata H.,
Watanabe M.,
Komatsu T.,
Mizushima-Sugano J.,
Satoh T.,
Shirai Y.,
Takahashi Y.,
Nakagawa K.,
Okumura K.,
Nagase T.,
Nomura N.,
Kikuchi H.,
Masuho Y.,
Yamashita R.,
Nakai K.,
Yada T.,
Nakamura Y.,
Ohara O.,
Isogai T.,
Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
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[8]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT VAL-227.
NIEHS SNPs program;
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
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[9]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G.,
Barlow K.F.,
McLay K.E.,
Kaul R.,
Swarbreck D.,
Dunham A.,
Scott C.E.,
Howe K.L.,
Woodfine K.,
Spencer C.C.A.,
Jones M.C.,
Gillson C.,
Searle S.,
Zhou Y.,
Kokocinski F.,
McDonald L.,
Evans R.,
Phillips K.,
Atkinson A., ![]()
Cooper R.,
Jones C.,
Hall R.E.,
Andrews T.D.,
Lloyd C.,
Ainscough R.,
Almeida J.P.,
Ambrose K.D.,
Anderson F.,
Andrew R.W.,
Ashwell R.I.S.,
Aubin K.,
Babbage A.K.,
Bagguley C.L.,
Bailey J.,
Beasley H.,
Bethel G.,
Bird C.P.,
Bray-Allen S.,
Brown J.Y.,
Brown A.J.,
Buckley D.,
Burton J.,
Bye J.,
Carder C.,
Chapman J.C.,
Clark S.Y.,
Clarke G.,
Clee C.,
Cobley V.,
Collier R.E.,
Corby N.,
Coville G.J.,
Davies J.,
Deadman R.,
Dunn M.,
Earthrowl M.,
Ellington A.G.,
Errington H.,
Frankish A.,
Frankland J.,
French L.,
Garner P.,
Garnett J.,
Gay L.,
Ghori M.R.J.,
Gibson R.,
Gilby L.M.,
Gillett W.,
Glithero R.J.,
Grafham D.V.,
Griffiths C.,
Griffiths-Jones S.,
Grocock R.,
Hammond S.,
Harrison E.S.I.,
Hart E.,
Haugen E.,
Heath P.D.,
Holmes S.,
Holt K.,
Howden P.J.,
Hunt A.R.,
Hunt S.E.,
Hunter G.,
Isherwood J.,
James R.,
Johnson C.,
Johnson D.,
Joy A.,
Kay M.,
Kershaw J.K.,
Kibukawa M.,
Kimberley A.M.,
King A.,
Knights A.J.,
Lad H.,
Laird G.,
Lawlor S.,
Leongamornlert D.A.,
Lloyd D.M.,
Loveland J.,
Lovell J.,
Lush M.J.,
Lyne R.,
Martin S.,
Mashreghi-Mohammadi M.,
Matthews L.,
Matthews N.S.W.,
McLaren S.,
Milne S.,
Mistry S.,
Moore M.J.F.,
Nickerson T.,
O'Dell C.N.,
Oliver K.,
Palmeiri A.,
Palmer S.A.,
Parker A.,
Patel D.,
Pearce A.V.,
Peck A.I.,
Pelan S.,
Phelps K.,
Phillimore B.J.,
Plumb R.,
Rajan J.,
Raymond C.,
Rouse G.,
Saenphimmachak C.,
Sehra H.K.,
Sheridan E.,
Shownkeen R.,
Sims S.,
Skuce C.D.,
Smith M.,
Steward C.,
Subramanian S.,
Sycamore N.,
Tracey A.,
Tromans A.,
Van Helmond Z.,
Wall M.,
Wallis J.M.,
White S.,
Whitehead S.L.,
Wilkinson J.E.,
Willey D.L.,
Williams H.,
Wilming L.,
Wray P.W.,
Wu Z.,
Coulson A.,
Vaudin M.,
Sulston J.E.,
Durbin R.M.,
Hubbard T.,
Wooster R.,
Dunham I.,
Carter N.P.,
McVean G.,
Ross M.T.,
Harrow J.,
Olson M.V.,
Beck S.,
Rogers J.,
Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
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[10]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Mammary gland, and Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[11]
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NUCLEOTIDE SEQUENCE [MRNA] OF 182-289 (ISOFORM 1), AND VARIANT VAL-227.
TISSUE=Ewing sarcoma;
DOI=10.1016/S0145-2126(99)00137-X; PubMed=10634649 [NCBI, ExPASy, EBI, Israel, Japan]
Okita H.,
Umezawa A.,
Fukuma M.,
Hata J.;
"Acute myeloid leukemia possessing jumping translocation is related to highly elevated levels of EAT/mcl-1, a Bcl-2 related gene with anti-apoptotic functions.";
Leuk. Res. 24:73-77(2000).
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[12]
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PROTEIN SEQUENCE OF N-TERMINUS OF FRAGMENTS OBTAINED BY CASPASE CLEAVAGE, AND MUTAGENESIS OF ASP-127 AND ASP-157.
DOI=10.1038/sj.onc.1207648; PubMed=15122313 [NCBI, ExPASy, EBI, Israel, Japan]
Michels J.,
O'Neill J.W.,
Dallman C.L.,
Mouzakiti A.,
Habens F.,
Brimmell M.,
Zhang K.Y.J.,
Craig R.W.,
Marcusson E.G.,
Johnson P.W.M.,
Packham G.;
"Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage.";
Oncogene 23:4818-4827(2004).
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[13]
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INDUCTION.
PubMed=9671497 [NCBI, ExPASy, EBI, Israel, Japan]
Chao J.-R.,
Wang J.-M.,
Lee S.-F.,
Peng H.-W.,
Lin Y.-H.,
Chou C.-H.,
Li J.-C.,
Huang H.-M.,
Chou C.-K.,
Kuo M.-L.,
Yen J.J.-Y.,
Yang-Yen H.-F.;
"Mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response.";
Mol. Cell. Biol. 18:4883-4898(1998).
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[14]
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INTERACTION WITH TPT1, AND SUBCELLULAR LOCATION.
DOI=10.1074/jbc.M207413200; PubMed=12149273 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang D.,
Li F.,
Weidner D.,
Mnjoyan Z.H.,
Fujise K.;
"Physical and functional interaction between myeloid cell leukemia 1 protein (MCL1) and fortilin. The potential role of MCL1 as a fortilin chaperone.";
J. Biol. Chem. 277:37430-37438(2002).
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[15]
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PHOSPHORYLATION AT SER-121 AND THR-163.
DOI=10.1074/jbc.M207951200; PubMed=12223490 [NCBI, ExPASy, EBI, Israel, Japan]
Inoshita S.,
Takeda K.,
Hatai T.,
Terada Y.,
Sano M.,
Hata J.,
Umezawa A.,
Ichijo H.;
"Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress.";
J. Biol. Chem. 277:43730-43734(2002).
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[16]
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INTERACTION WITH BAK, AND SUBCELLULAR LOCATION.
DOI=10.1038/ncb1123; PubMed=15077116 [NCBI, ExPASy, EBI, Israel, Japan]
Leu J.I.-J.,
Dumont P.,
Hafey M.,
Murphy M.E.,
George D.L.;
"Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.";
Nat. Cell Biol. 6:443-450(2004).
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[17]
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PHOSPHORYLATION AT THR-163, AND MUTAGENESIS OF SER-162 AND THR-163.
DOI=10.1038/sj.onc.1207692; PubMed=15241487 [NCBI, ExPASy, EBI, Israel, Japan]
Domina A.M.,
Vrana J.A.,
Gregory M.A.,
Hann S.R.,
Craig R.W.;
"MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol.";
Oncogene 23:5301-5315(2004).
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[18]
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UBIQUITINATION, AND MUTAGENESIS OF LYS-5; LYS-40; LYS-136; LYS-194; LYS-197; LYS-208 AND LYS-234.
DOI=10.1016/j.cell.2005.06.009; PubMed=15989957 [NCBI, ExPASy, EBI, Israel, Japan]
Zhong Q.,
Gao W.,
Du F.,
Wang X.;
"Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis.";
Cell 121:1085-1095(2005).
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[19]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-163, AND MASS SPECTROMETRY.
DOI=10.1021/pr0705441; PubMed=18220336 [NCBI, ExPASy, EBI, Israel, Japan]
Cantin G.T.,
Yi W.,
Lu B.,
Park S.K.,
Xu T.,
Lee J.-D.,
Yates J.R. III;
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.";
J. Proteome Res. 7:1346-1351(2008).
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[20]
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X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 151-307 IN COMPLEXES WITH PMAIP1 AND BCL2L11.
DOI=10.1073/pnas.0701297104; PubMed=17389404 [NCBI, ExPASy, EBI, Israel, Japan]
Czabotar P.E.,
Lee E.F.,
van Delft M.F.,
Day C.L.,
Smith B.J.,
Huang D.C.S.,
Fairlie W.D.,
Hinds M.G.,
Colman P.M.;
"Structural insights into the degradation of Mcl-1 induced by BH3 domains.";
Proc. Natl. Acad. Sci. U.S.A. 104:6217-6222(2007).
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[21]
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X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 172-327 IN COMPLEX WITH BCL2L11.
Bare E.,
Grant R.A.,
Keating A.E.;
"X-ray crystal structure of human MCL-1 in complex with BIM BH3.";
Submitted (JUN-2007) to the PDB data bank.
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[22]
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VARIANT [LARGE SCALE ANALYSIS] LEU-231.
DOI=10.1038/nature07485; PubMed=18987736 [NCBI, ExPASy, EBI, Israel, Japan]
Ley T.J.,
Mardis E.R.,
Ding L.,
Fulton B.,
McLellan M.D.,
Chen K.,
Dooling D.,
Dunford-Shore B.H.,
McGrath S.,
Hickenbotham M.,
Cook L.,
Abbott R.,
Larson D.E.,
Koboldt D.C.,
Pohl C.,
Smith S.,
Hawkins A.,
Abbott S.,
Locke D., ![]()
Hillier L.W.,
Miner T.,
Fulton L.,
Magrini V.,
Wylie T.,
Glasscock J.,
Conyers J.,
Sander N.,
Shi X.,
Osborne J.R.,
Minx P.,
Gordon D.,
Chinwalla A.,
Zhao Y.,
Ries R.E.,
Payton J.E.,
Westervelt P.,
Tomasson M.H.,
Watson M.,
Baty J.,
Ivanovich J.,
Heath S.,
Shannon W.D.,
Nagarajan R.,
Walter M.J.,
Link D.C.,
Graubert T.A.,
DiPersio J.F.,
Wilson R.K.;
"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.";
Nature 456:66-72(2008).
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