ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q07647

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name GTR3_RAT
Primary accession number Q07647
Secondary accession number Q62729
Integrated into Swiss-Prot on October 1, 1994
Sequence was last modified on October 1, 1994 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 71)
Name and origin of the protein
Protein name Solute carrier family 2, facilitated glucose transporter member 3
Synonyms Glucose transporter type 3, brain
GLUT-3
Gene name
Name: Slc2a3
Synonyms: Glut-3, Glut3
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0014-5793(93)80697-S; PubMed=8243635 [NCBI, ExPASy, EBI, Israel, Japan]
Nagamatsu S., Sawa H., Kamada K., Nakamichi Y., Yoshimoto K., Hoshino T.;
"Neuron-specific glucose transporter (NSGT): CNS distribution of GLUT3 rat glucose transporter (RGT3) in rat central neurons.";
FEBS Lett. 334:289-295(1993).
[2]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
TISSUE=Brain;
DOI=10.1016/0024-3205(95)00058-E; PubMed=7475896 [NCBI, ExPASy, EBI, Israel, Japan]
Krishnan S.N., Haddad G.G.;
"Cloning of glucose transporter-3 (GLUT3) cDNA from rat brain.";
Life Sci. 56:1193-1197(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D13962; BAA03065.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U17978; AAA62503.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00198723; -.
PIR S38981; S38981.
RefSeq NP_058798.2; -.
UniGene Rn.95055
3D structure databases
ModBase Q07647.
Protein family/group databases
TCDB 2.A.1.1.12; major facilitator superfamily (MFS).
PTM databases
PhosphoSite Q07647; -.
Organism-specific databases
RGD 3706; Slc2a3.
Gene expression databases
ArrayExpress Q07647; -.
GermOnline ENSRNOG00000008376; Rattus norvegicus.
Ontologies
GO
GO:0005901; Cellular component: caveola (inferred from direct assay from RGD).
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0030672; Cellular component: synaptic vesicle membrane (inferred from direct assay from RGD).
GO:0055056; Molecular function: D-glucose transmembrane transporter activity (inferred from direct assay from RGD).
GO:0016936; Molecular function: galactoside binding (inferred from direct assay from RGD).
GO:0005536; Molecular function: glucose binding (inferred from direct assay from RGD).
GO:0019900; Molecular function: kinase binding (inferred from physical interaction from RGD).
GO:0005351; Molecular function: sugar:hydrogen symporter activity (inferred from electronic annotation from UniProtKB-KW).
GO:0033222; Molecular function: xylose binding (inferred from direct assay from RGD).
GO:0046323; Biological process: glucose import (inferred from direct assay from RGD).
GO:0043066; Biological process: negative regulation of apoptosis (inferred from direct assay from RGD).
GO:0055085; Biological process: transmembrane transport (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR002945; Glc_transpt_3.
IPR005828; Sub_transporter.
IPR003663; Sugar/inositol_transpt.
IPR005829; Sugar_transporter_CS.
Graphical view of domain structure.
PANTHER PTHR11600:SF113; Glu_transpt3; 1.
Pfam PF00083; Sugar_tr; 1.
Pfam graphical view of domain structure.
PRINTS PR01192; GLUCTRSPORT3.
PR00171; SUGRTRNSPORT.
TIGRFAMs TIGR00879; SP; 1.
PROSITE PS50850; MFS; 1.
PS00216; SUGAR_TRANSPORT_1; 1.
PS00217; SUGAR_TRANSPORT_2; 1.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
Ensembl ENSRNOG00000008376; Rattus norvegicus. [Contig view]
GeneID 25551; -.
KEGG rno:25551; -.
Phylogenomic databases
HOVERGEN Q07647; -.
Other
NextBio 607101; -.
ProtoNet Q07647.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glycoprotein; Membrane; Sugar transport; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   493  493     Solute carrier family 2, facilitated glucose transporter member 3. PRO_0000050358
TOPO_DOM   1    10  10     Cytoplasmic (Potential). 
TRANSMEM   11    31  21     1 (Potential). 
TOPO_DOM   32    64  33     Extracellular (Potential). 
TRANSMEM   65    85  21     2 (Potential). 
TOPO_DOM   86    93  8     Cytoplasmic (Potential). 
TRANSMEM   94   114  21     3 (Potential). 
TOPO_DOM   115   124  10     Extracellular (Potential). 
TRANSMEM   125   145  21     4 (Potential). 
TOPO_DOM   146   153  8     Cytoplasmic (Potential). 
TRANSMEM   154   174  21     5 (Potential). 
TOPO_DOM   175   183  9     Extracellular (Potential). 
TRANSMEM   184   204  21     6 (Potential). 
TOPO_DOM   205   269  65     Cytoplasmic (Potential). 
TRANSMEM   270   290  21     7 (Potential). 
TOPO_DOM   291   304  14     Extracellular (Potential). 
TRANSMEM   305   325  21     8 (Potential). 
TOPO_DOM   326   334  9     Cytoplasmic (Potential). 
TRANSMEM   335   355  21     9 (Potential). 
TOPO_DOM   356   363  8     Extracellular (Potential). 
TRANSMEM   364   384  21     10 (Potential). 
TOPO_DOM   385   399  15     Cytoplasmic (Potential). 
TRANSMEM   400   420  21     11 (Potential). 
TOPO_DOM   421   424  4     Extracellular (Potential). 
TRANSMEM   425   445  21     12 (Potential). 
TOPO_DOM   446   493  48     Cytoplasmic (Potential). 
REGION   277   279  3     Defines substrate specificity (By similarity). 
CARBOHYD   43    43        N-linked (GlcNAc...) (Potential). 
CONFLICT   55    55        R -> S (in Ref. 2; AAA62503). 
CONFLICT   447   447        S -> F (in Ref. 2; AAA62503). 
CONFLICT   470   470        H -> Q (in Ref. 2; AAA62503). 
Sequence information
Length: 493 AA [This is the length of the unprocessed precursor] Molecular weight: 53581 Da [This is the MW of the unprocessed precursor] CRC64: 745446B59BDF4399 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGTAKVTPSL VFAVTVATIG SFQFGYNTGV INAPETIIKD FLNYTLEERL EDLPREGLLT 

        70         80         90        100        110        120 
TLWSLCVAIF SVGGMIGSFS VGLFVNRFGR RNSMLLVNLI AILGGCLMGF AKIAESVEML 

       130        140        150        160        170        180 
ILGRLIIGIF CGLCTGFVPM YIGEVSPTAL RGAFGTLNQL GIVVGILVAQ VFGLDFILGS 

       190        200        210        220        230        240 
EELWPGLLGL TIIPAILQSA ALPFCPESPR FLLINRKEED QATEILQRLW GTPDVIQEIQ 

       250        260        270        280        290        300 
EMKDESIRMS QEKQVTVLEL FKSPSYFQPL LISVVLQLSQ QFSGINAVFY YSTGIFQDAG 

       310        320        330        340        350        360 
VQEPIYATIG AGVVNTIFTV VSLFLVERAG RRTLHMIGLG GMAVCSVFMT ISLLLKDEYE 

       370        380        390        400        410        420 
AMSFVCIVAI LVYVAFFEIG PGPIPWFIVA ELFSQGPRPA AMAVAGCSNW TSNFLVGMFF 

       430        440        450        460        470        480 
PSAAAYLGAY VFIIFAAFLV FFLIFTSFKV PETKGRTFED ITRAFEGQAH SGKGSAGVEL 

       490 
NSMQPVKETP GNA
Q07647 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by ca flag CBR Canada Mirror sites: Australia Brazil China Korea Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!