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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Pancreas;
PubMed=8326004 [NCBI, ExPASy, EBI, Israel, Japan]
Pietropaolo M.,
Castano L.,
Babu S.,
Buelow R.,
Kuo Y.-L.S.,
Martin S.,
Martin A.,
Powers A.C.,
Prochazka M.,
Naggert J.,
Leiter E.H.,
Eisenbarth G.S.;
"Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen.";
J. Clin. Invest. 92:359-371(1993).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Pancreatic islet;
DOI=10.1016/0925-4439(94)90113-9; PubMed=7918678 [NCBI, ExPASy, EBI, Israel, Japan]
Miyazaki I.,
Gaedigk R.,
Hui M.F.,
Cheung R.K.,
Morkowski J.,
Rajotte R.V.,
Dosch H.-M.;
"Cloning of human and rat p69 cDNA, a candidate autoimmune target in type 1 diabetes.";
Biochim. Biophys. Acta 1227:101-104(1994).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1006/geno.1996.0641; PubMed=8975715 [NCBI, ExPASy, EBI, Israel, Japan]
Gaedigk R.,
Karges W.,
Hui M.F.,
Scherer S.W.,
Dosch H.-M.;
"Genomic organization and transcript analysis of ICAp69, a target antigen in diabetic autoimmunity.";
Genomics 38:382-391(1996).
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[4]
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SUBCELLULAR LOCATION.
DOI=10.1074/jbc.M213222200; PubMed=12682071 [NCBI, ExPASy, EBI, Israel, Japan]
Spitzenberger F.,
Pietropaolo S.,
Verkade P.,
Habermann B.,
Lacas-Gervais S.,
Mziaut H.,
Pietropaolo M.,
Solimena M.;
"Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells.";
J. Biol. Chem. 278:26166-26173(2003).
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- FUNCTION: May play a role in neurotransmitter secretion (By similarity).
- INTERACTION:
P26441:CNTF; NbExp=1; IntAct=EBI-1046751, EBI-1050897;
Q14525:KRT33B; NbExp=1; IntAct=EBI-1046751, EBI-1049638;
Q9HB66:MKKS; NbExp=1; IntAct=EBI-1046751, EBI-1054754;
O75716:STK16; NbExp=1; IntAct=EBI-1046751, EBI-1046308;
- SUBCELLULAR LOCATION: Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein (Potential). Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein (Potential). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein (Potential). Note=Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules.
- TISSUE SPECIFICITY: Expressed abundantly in pancreas, heart and brain with low levels of expression in lung, kidney, liver and thyroid.
- DISEASE: Identified as an autoantigen in insulin-dependent diabetes mellitus.
- SIMILARITY: Contains 1 AH domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 483 AA [This is the length of the unprocessed precursor] |
Molecular weight: 54645 Da [This is the MW of the unprocessed precursor] |
CRC64: 1696F928EE7454C9 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MSGHKCSYPW DLQDRYAQDK SVVNKMQQKY WETKQAFIKA TGKKEDEHVV ASDADLDAKL
70 80 90 100 110 120
ELFHSIQRTC LDLSKAIVLY QKRICFLSQE ENELGKFLRS QGFQDKTRAG KMMQATGKAL
130 140 150 160 170 180
CFSSQQRLAL RNPLCRFHQE VETFRHRAIS DTWLTVNRME QCRTEYRGAL LWMKDVSQEL
190 200 210 220 230 240
DPDLYKQMEK FRKVQTQVRL AKKNFDKLKM DVCQKVDLLG ASRCNLLSHM LATYQTTLLH
250 260 270 280 290 300
FWEKTSHTMA AIHESFKGYQ PYEFTTLKSL QDPMKKLVEK EEKKKINQQE STDAAVQEPS
310 320 330 340 350 360
QLISLEEENQ RKESSSFKTE DGKSILSALD KGSTHTACSG PIDELLDMKS EEGACLGPVA
370 380 390 400 410 420
GTPEPEGADK DDLLLLSEIF NASSLEEGEF SKEWAAVFGD GQVKEPVPTM ALGEPDPKAQ
430 440 450 460 470 480
TGSGFLPSQL LDQNMKDLQA SLQEPAKAAS DLTAWFSLFA DLDPLSNPDA VGKTDKEHEL
LNA
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Q05084 in FASTA format |
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