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UniProtKB/Swiss-Prot entry Q04440

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name COX1_BACPF
Primary accession number Q04440
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1994
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 59)
Name and origin of the protein
Protein name Cytochrome c oxidase subunit 1
Synonyms EC 1.9.3.1
Cytochrome c oxidase polypeptide I
Cytochrome aa3 subunit 1
Gene name
Name: ctaD
From
Bacillus pseudofirmus [TaxID: 79885] 
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-13.
STRAIN=OF4;
PubMed=7678007 [NCBI, ExPASy, EBI, Israel, Japan]
Quirk P.G., Hicks D.B., Krulwich T.A.;
"Cloning of the cta operon from alkaliphilic Bacillus firmus OF4 and characterization of the pH-regulated cytochrome caa3 oxidase it encodes.";
J. Biol. Chem. 268:678-685(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M94110; AAA22365.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P18401; 1FFT. [HSSP ENTRY / PDB]
ModBase Q04440.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0005746; Cellular component: mitochondrial respiratory chain (inferred from electronic annotation from UniProtKB-KW).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005507; Molecular function: copper ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004129; Molecular function: cytochrome-c oxidase activity (inferred from electronic annotation from InterPro).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0020037; Molecular function: heme binding (inferred from electronic annotation from InterPro).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from InterPro).
GO:0009060; Biological process: aerobic respiration (inferred from electronic annotation from InterPro).
GO:0022900; Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810; Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000883; COX1.
IPR014241; COX1_bac-type.
Graphical view of domain structure.
Gene3D G3DSA:1.20.210.10; COX1; 1.
PANTHER PTHR10422; COX1; 1.
Pfam PF00115; COX1; 1.
Pfam graphical view of domain structure.
PRINTS PR01165; CYCOXIDASEI.
TIGRFAMs TIGR02891; CtaD_CoxA; 1.
PROSITE PS50855; COX1; 1.
PS00077; COX1_CUB; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q04440.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell membrane; Copper; Direct protein sequencing; Electron transport; Heme; Iron; Membrane; Metal-binding; Oxidoreductase; Respiratory chain; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   625  624     Cytochrome c oxidase subunit 1. PRO_0000183434
TRANSMEM   23    43  21     Potential. 
TRANSMEM   72    92  21     Potential. 
TRANSMEM   99   119  21     Potential. 
TRANSMEM   151   171  21     Potential. 
TRANSMEM   195   215  21     Potential. 
TRANSMEM   240   260  21     Potential. 
TRANSMEM   272   292  21     Potential. 
TRANSMEM   309   329  21     Potential. 
TRANSMEM   343   363  21     Potential. 
TRANSMEM   382   402  21     Potential. 
TRANSMEM   417   437  21     Potential. 
TRANSMEM   460   480  21     Potential. 
TRANSMEM   551   571  21     Potential. 
TRANSMEM   577   597  21     Potential. 
METAL   69    69        Iron (heme A axial ligand) (Probable). 
METAL   246   246        Copper B (Probable). 
METAL   250   250        Copper B (Probable). 
METAL   295   295        Copper B (Probable). 
METAL   296   296        Copper B (Probable). 
METAL   381   381        Iron (heme A3 axial ligand) (Probable). 
METAL   383   383        Iron (heme A axial ligand) (Probable). 
CROSSLNK   246   250        1'-histidyl-3'-tyrosine (His-Tyr) (By similarity). 
Sequence information
Length: 625 AA [This is the length of the unprocessed precursor] Molecular weight: 69885 Da [This is the MW of the unprocessed precursor] CRC64: 6D805E8F9DA1E4A4 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MATQKQEKSV IWDWLTTVDH KKIAIMYLIA GTLFFVKAGV MALFMRIQLM YPEMNFLSGQ 

        70         80         90        100        110        120 
TFNEFITMHG TIMLFLAATP LLFAFMNYVI PLQIGARDVA FPFVNALGFW IFFFGGLLLS 

       130        140        150        160        170        180 
LSWFFGGGPD AGWTAYVPLS SRDYGGLGID FYVLGLQVSG IGTLISAINF LVTIVNMRAP 

       190        200        210        220        230        240 
GMTMMRLPLF VWTSFISSTL ILFAFTPLAA GLALLMLDRL FEAQYFIPSM GGNVVLWQHI 

       250        260        270        280        290        300 
FWIFGHPEVY ILVLPAFGII SEVIPAFSRK RLFGYTAMVF ATMIIAFLGF MVWAHHMFTV 

       310        320        330        340        350        360 
GMGPVANSIF AVATMTIAVP TGIKIFNWLF TMWGGKITFN TAMLFASSFV PTFVLGGVTG 

       370        380        390        400        410        420 
VMLAMAPVDY LYHDTYFVVA HFHYIIVGGI VLSLFAGLFY WYPKMFGHML NETLGKLFFW 

       430        440        450        460        470        480 
VFYIGFHLTF FVQHLLGLMG MPRRVYTYLG DQGLDAFNFI STIGTFFMSA GVILLVINVI 

       490        500        510        520        530        540 
YSAFKGERVT VADPWDARTL EWATPTPVPE YNFAQTPQVR SLDPLFYEKI HGDGTMKPAE 

       550        560        570        580        590        600 
PVTDIHMPNG SILPFIMSIG LFFAGFGLIM LNMDKPIINP WIVAIGGLAL TFGCMFVRSI 

       610        620 
KEDHGYHIPA EQVKADLAEL KKGGN
Q04440 in FASTA format

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