Epithelial discoidin domain receptor 1
EC 2.7.10.1
Tyrosine kinase DDR
Discoidin receptor tyrosine kinase
Tyrosine-protein kinase CAK
Cell adhesion kinase
Protein-tyrosine kinase MPK-6
CD167 antigen-like family member A
CD167a antigen

Gene name

	Name:	Ddr1
	Synonyms:	Cak, Eddr1, Mpk6

From

Mus musculus (Mouse)

[TaxID: 10090]

Taxonomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.

Protein existence

2: Evidence at transcript level;

References

[1]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). STRAIN=C57BL/6; PubMed=8622863 [NCBI, ExPASy, EBI, Israel, Japan] Perez J.L., Jing S.Q., Wong T.W.; "Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines."; Oncogene 12:1469-1477(1996).
[2]	NUCLEOTIDE SEQUENCE [MRNA] OF 766-822. STRAIN=C57BL/6; TISSUE=Embryonic brain; PubMed=1281307 [NCBI, ExPASy, EBI, Israel, Japan] Gilardi-Hebenstreit P., Nieto M.A., Frain M., Mattei M.-G., Chestier A., Wilkinson D.G., Charnay P.; "An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain."; Oncogene 7:2499-2506(1992).

Comments

FUNCTION: May be involved in cell-cell interactions and recognition (By similarity).
CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing.

Name	1
Synonyms	CAK I
Isoform ID	Q03146-1
This is the isoform sequence displayed in this entry.

Name	2
Synonyms	CAK II
Isoform ID	Q03146-2
Features which should be applied to build the isoform sequence: VSP_002954.

TISSUE SPECIFICITY: Isoform 1 is predominant and is expressed in developing embryo and adult brain. Isoform 2 is expressed in various epithelial cells.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
SIMILARITY: Contains 1 F5/8 type C domain.
SIMILARITY: Contains 1 protein kinase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L57509; AAB05209.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X57240; CAA40516.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

S30502; S30502.

NP_031610.1; -.

3D structure databases

HSSP

Q62838; 1LUF. [HSSP ENTRY / PDB]

ModBase

Q03146.

PTM databases

PhosphoSite

Q03146; -.

Organism-specific databases

MGI

MGI:99216; Ddr1.

Gene expression databases

ArrayExpress

Q03146; -.

CleanEx

MM_DDR1; -.

GermOnline

ENSMUSG00000003534; Mus musculus.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886;	Cellular component: plasma membrane (inferred from direct assay from MGI).
GO:0005524;	Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0004714;	Molecular function: transmembrane receptor protein tyrosine kinase activity (inferred from electronic annotation from InterPro).
GO:0043583;	Biological process: ear development (inferred from mutant phenotype from MGI).
GO:0007566;	Biological process: embryo implantation (inferred from mutant phenotype from MGI).
GO:0030879;	Biological process: mammary gland development (inferred from mutant phenotype from MGI).
GO:0008285;	Biological process: negative regulation of cell proliferation (inferred from mutant phenotype from MGI).
GO:0018108;	Biological process: peptidyl-tyrosine phosphorylation (inferred from direct assay from MGI).
GO:0001558;	Biological process: regulation of cell growth (inferred from mutant phenotype from MGI).
GO:0001952;	Biological process: regulation of cell-matrix adhesion (inferred from mutant phenotype from MGI).
GO:0051789;	Biological process: response to protein stimulus (inferred from mutant phenotype from MGI).
GO:0007169;	Biological process: transmembrane receptor protein tyrosine kinase signaling pathway (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR000421; Coagulation_factor_5/8-type_C.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR002011; Recept_tyr_kinase-II_CS.
IPR001245; Tyr_pkinase.
IPR008266; Tyr_pkinase_AS.
Graphical view of domain structure.

Pfam

PF00754; F5_F8_type_C; 1.
PF07714; Pkinase_Tyr; 1.
Pfam graphical view of domain structure.

PRINTS

PR00109; TYRKINASE.

ProDom

PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00231; FA58C; 1.
SM00219; TyrKc; 1.
SMART graphical view of domain structure.

PROSITE

PS01285; FA58C_1; 1.
PS01286; FA58C_2; 1.
PS50022; FA58C_3; 1.
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
PROSITE graphical view of domain structure (profiles).

ProtoNet

Q03146.

Genome annotation databases

Ensembl

ENSMUSG00000003534; Mus musculus. [Contig view]

GeneID

12305; -.

KEGG

mmu:12305; -.

Phylogenomic databases

HOGENOM

Q03146; -.

HOVERGEN

Q03146; -.

Other

NextBio

280834; -.

SOURCE

Ddr1; Mus musculus.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; ATP-binding; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Signal; Transferase; Transmembrane; Tyrosine-protein kinase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 19`	`19`	`Potential.`
`CHAIN`	`20 911`	`892`	`Epithelial discoidin domain-containing receptor 1.`	`PRO_0000016743`
`TOPO_DOM`	`20 414`	`395`	`Extracellular (Potential).`
`TRANSMEM`	`415 441`	`27`	`Potential.`
`TOPO_DOM`	`442 911`	`470`	`Cytoplasmic (Potential).`
`DOMAIN`	`32 186`	`155`	`F5/8 type C.`
`DOMAIN`	`608 903`	`296`	`Protein kinase.`
`NP_BIND`	`614 622`	`9`	`ATP (By similarity).`
`COMPBIAS`	`379 413`	`35`	`Gly/Pro-rich.`
`COMPBIAS`	`474 599`	`126`	`Gly/Pro-rich.`
`ACT_SITE`	`764 764`		`Proton acceptor (By similarity).`
`BINDING`	`653 653`		`ATP (By similarity).`
`MOD_RES`	`511 511`		`Phosphotyrosine; by autocatalysis (By similarity).`
`MOD_RES`	`790 790`		`Phosphotyrosine; by autocatalysis (By similarity).`
`MOD_RES`	`794 794`		`Phosphotyrosine; by autocatalysis (By similarity).`
`MOD_RES`	`795 795`		`Phosphotyrosine; by autocatalysis (By similarity).`
`CARBOHYD`	`213 213`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`262 262`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`372 372`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`392 392`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`32 186`		`By similarity.`
`VAR_SEQ`	`503 539`		`Missing (in isoform 2).`	`VSP_002954`

Sequence information

Length: 911 AA [This is the length of the unprocessed precursor]

Molecular weight: 101161 Da [This is the MW of the unprocessed precursor]

CRC64: DBB7FE03DDD79510 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGTGTLSSLL LLLLLVTIGD ADMKGHFDPA KCRYALGMQD RTIPDSDISV SSSWSDSTAA 

        70         80         90        100        110        120 
RHSRLESSDG DGAWCPAGPV FPKEEEYLQV DLRRLHLVAL VGTQGRHAGG LGKEFSRSYR 

       130        140        150        160        170        180 
LRYSRDGRRW MDWKDRWGQE VISGNEDPGG VVLKDLGPPM VARLVRFYPR ADRVMSVCLR 

       190        200        210        220        230        240 
VELYGCLWRD GLLSYTAPVG QTMQLSEVMV HLNDSTYDGY TAGGLQYGGL GQLADGVVGL 

       250        260        270        280        290        300 
DDFRQSQELR VWPGYDYVGW SNQSFPTGYV EMEFEFDRLR TFQTMQVHCN NMHTLGARLP 

       310        320        330        340        350        360 
GGVECRFKRG PAMAWEGEPV RHALGGSLGD PRARAISVPL GGHVGRFLQC RFLFAGPWLL 

       370        380        390        400        410        420 
FSEISFISDV VNDSSDTFPP APWWPPGPPP TNFSSLELEP RGQQPVAKAE GSPTAILIGC 

       430        440        450        460        470        480 
LVAIILLLLL IIALMLWRLH WRRLLSKAER RVLEEELTVH LSVPGDTILI NNRPGPREPP 

       490        500        510        520        530        540 
PYQEPRPRGT PPHSAPCVPN GSALLLSNPA YRLLLATYAR PPRGPGPPTP AWAKPTNTQA 

       550        560        570        580        590        600 
CSGDYMEPEK PGAPLLPPPP QNSVPHYAEA DIVTLQGVTG GNTYAVPALP PGAVGDGPPR 

       610        620        630        640        650        660 
VDFPRSRLRF KEKLGEGQFG EVHLCEVEDP QDLVSSDFPI SVHKGHPLLV AVKILRPDAT 

       670        680        690        700        710        720 
KNARNDFLKE VKIMSRLKDP NIIRLLGVCV QDDPLCMITD YMENGDLNQF LSARQLENKA 

       730        740        750        760        770        780 
TQGLSGDTES DQGPTISYPM LLHVGAQIAS GMRYLATLNF VHRDLATRNC LVGENFTIKI 

       790        800        810        820        830        840 
ADFGMSRNLY AGDYYRVQGR AVLPIRWMAW ECILMGKFTT ASDVWAFGVT LWEVLMLCRS 

       850        860        870        880        890        900 
QPFGQLTDEQ VIENAGEFFR DQGRQVYLSR PPACPQTLYE LMLRCWSREP EQRPPFAQLH 

       910 
RFLADDALNT V

Q03146 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools