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UniProtKB/Swiss-Prot entry Q01860


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PO5F1_HUMAN
Primary accession number Q01860
Secondary accession numbers A6NCS1 A6NLL8 P31359 Q15167 Q15168 Q16422 Q5STF3 Q5STF4
Integrated into Swiss-Prot on July 1, 1993
Sequence was last modified on July 1, 1993 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 100)
Name and origin of the protein
Protein name POU domain, class 5, transcription factor 1
Synonyms Octamer-binding transcription factor 3
Oct-3
Oct-4
Gene name
Name: POU5F1
Synonyms: OCT3, OCT4, OTF3
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), VARIANTS ALA-322 AND LEU-357, AND TISSUE SPECIFICITY.
TISSUE=Kidney;
DOI=10.1093/nar/20.17.4613; PubMed=1408763 [NCBI, ExPASy, EBI, Israel, Japan]
Takeda J., Seino S., Bell G.I.;
"Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues.";
Nucleic Acids Res. 20:4613-4620(1992).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Peripheral blood leukocyte;
DOI=10.1534/genetics.106.057034; PubMed=16702430 [NCBI, ExPASy, EBI, Israel, Japan]
Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A., Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S.;
"Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.";
Genetics 173:1555-1570(2006).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Shiina S., Tamiya G., Oka A., Inoko H.;
"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02055; PubMed=14574404 [NCBI, ExPASy, EBI, Israel, Japan]
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
"The DNA sequence and analysis of human chromosome 6.";
Nature 425:805-811(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
NUCLEOTIDE SEQUENCE [MRNA] OF 188-274, AND TISSUE SPECIFICITY.
TISSUE=Heart, and Skeletal muscle;
DOI=10.1111/j.1432-1033.1994.tb18676.x; PubMed=7908264 [NCBI, ExPASy, EBI, Israel, Japan]
Wey E., Lyons G.E., Schaefer B.W.;
"A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues.";
Eur. J. Biochem. 220:753-762(1994).
[8]
NUCLEOTIDE SEQUENCE [MRNA] OF 212-283.
PubMed=8567814 [NCBI, ExPASy, EBI, Israel, Japan]
Abdel-Rahman B., Fiddler M., Rappolee D., Pergament E.;
"Expression of transcription regulating genes in human preimplantation embryos.";
Hum. Reprod. 10:2787-2792(1995).
[9]
IDENTIFICATION.
DOI=10.1016/j.bbrc.2005.09.157; PubMed=16229821 [NCBI, ExPASy, EBI, Israel, Japan]
Suo G., Han J., Wang X., Zhang J., Zhao Y., Zhao Y., Dai J.;
"Oct4 pseudogenes are transcribed in cancers.";
Biochem. Biophys. Res. Commun. 337:1047-1051(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z11898; CAA77951.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z11899; CAA77952.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB088113; BAC54946.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB202105; BAE78630.1; -; Genomic_RNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB103619; BAF31281.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BA000025; BAB63311.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL662833; CAI17407.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL662833; CAI17408.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL662844; CAI18331.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL773544; CAI18485.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL773544; CAI18486.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX088580; CAI18708.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX088580; CAI18709.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR759815; CAQ07092.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR759815; CAQ07093.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR388229; CAQ09226.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR388229; CAQ09227.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR847794; CAQ10780.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR847794; CAQ10781.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CH471081; EAX03367.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CH471081; EAX03368.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC117435; AAI17436.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC117437; AAI17438.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z21963; CAA79974.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z21964; CAA79975.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S81255; AAB35990.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00219089; -.
IPI00294177; -.
PIR S25561; S25561.
S32652; S32652.
RefSeq NP_002692.2; -.
NP_976034.3; -.
UniGene Hs.249184
3D structure databases
HSSP P20263; 1OCP. [HSSP ENTRY / PDB]
ModBase Q01860.
Protein-protein interaction databases
IntAct Q01860; 1.
PTM databases
PhosphoSite Q01860; -.
Organism-specific databases
GeneCards GC06M031240; -.
H-InvDB HIX0050476; -.
HIX0058021; -.
HIX0058196; -.
HGNC HGNC:9221; POU5F1.
GenAtlas POU5F1.
MIM 164177; gene. [NCBI / EBI]
PharmGKB PA33545; -.
Gene expression databases
Bgee Q01860; -.
GermOnline ENSG00000204531; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from direct assay from UniProtKB).
GO:0005634; Cellular component: nucleus (inferred by curator from HGNC).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0043565; Molecular function: sequence-specific DNA binding (inferred from electronic annotation from InterPro).
GO:0003700; Molecular function: transcription factor activity (inferred from direct assay from HGNC).
GO:0009653; Biological process: anatomical structure morphogenesis (traceable author statement from ProtInc).
GO:0006355; Biological process: regulation of transcription, DNA-dependent (inferred from direct assay from HGNC).
GO:0006350; Biological process: transcription (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001356; Homeobox.
IPR017970; Homeobox_CS.
IPR012287; Homeodomain-rel.
IPR013847; POU.
IPR015585; POU_dom_5.
IPR000327; POU_specific.
Graphical view of domain structure.
Gene3D G3DSA:1.10.10.60; Homeodomain-rel; 1.
PANTHER PTHR11636:SF15; POU_5; 1.
Pfam PF00046; Homeobox; 1.
PF00157; Pou; 1.
Pfam graphical view of domain structure.
PRINTS PR00028; POUDOMAIN.
ProDom PD000010; Homeobox; 1.
PD000583; POU; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00389; HOX; 1.
SM00352; POU; 1.
SMART graphical view of domain structure.
PROSITE PS00027; HOMEOBOX_1; 1.
PS50071; HOMEOBOX_2; 1.
PS00035; POU_1; 1.
PS00465; POU_2; 1.
PS51179; POU_3; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q01860; -.
Genome annotation databases
Ensembl ENSG00000204531; Homo sapiens. [Contig view]
ENSG00000206349; Homo sapiens. [Contig view]
ENSG00000206454; Homo sapiens. [Contig view]
GeneID 5460; -.
KEGG hsa:5460; -.
Phylogenomic databases
HOVERGEN Q01860; -.
OMA Q01860; LENMFLQ.
Other
NextBio 21135; -.
SOURCE POU5F1; Homo sapiens.
ProtoNet Q01860.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; DNA-binding; Homeobox; Isopeptide bond; Nucleus; Polymorphism; Transcription; Transcription regulation; Ubl conjugation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   360  360     POU domain, class 5, transcription factor 1. PRO_0000100747
DOMAIN   138   212  75     POU-specific. 
DNA_BIND   230   289  60     Homeobox. 
CROSSLNK   123   123        Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) (By similarity). 
VAR_SEQ   1   135        MAGHLASDFAFSPPPGGGGDGPGGPEPGWVDPRTWLSFQG PPGGPGIGPGVGPGSEVWGIPPCPPPYEFCGGMAYCGPQV GVGLVPQGGLETSQPEGEAGVGVESNSDGASPEPCTVTPG AVKLEKEKLEQNPEE -> MHFYRLFLGATRRFLNPEWKGEIDNWCVYVLTSLLPFKIQ (in isoform B). VSP_002333
VARIANT   226   226  1     L -> F (in dbSNP:rs1150767 [NCBI]). VAR_046203 
VARIANT   322   322  1     T -> A. VAR_003774 
VARIANT   351   351  1     T -> I (in dbSNP:rs1061120 [NCBI]). VAR_046204 
VARIANT   357   357  1     M -> L. VAR_003775 
CONFLICT   189   189        A -> G (in Ref. 7; CAA79974). 
CONFLICT   220   220        I -> T (in Ref. 7; CAA79974). 
CONFLICT   227   227        V -> L (in Ref. 7; CAA79974). 
CONFLICT   230   230        R -> G (in Ref. 7; CAA79975). 
CONFLICT   240   240        R -> Q (in Ref. 7; CAA79975). 
CONFLICT   251   251        Q -> R (in Ref. 7; CAA79975). 
CONFLICT   272   272        D -> DVVR (in Ref. 8; AAB35990). 
Sequence information
Length: 360 AA [This is the length of the unprocessed precursor] Molecular weight: 38571 Da [This is the MW of the unprocessed precursor] CRC64: 934C58DAEA0C535B [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAGHLASDFA FSPPPGGGGD GPGGPEPGWV DPRTWLSFQG PPGGPGIGPG VGPGSEVWGI 

        70         80         90        100        110        120 
PPCPPPYEFC GGMAYCGPQV GVGLVPQGGL ETSQPEGEAG VGVESNSDGA SPEPCTVTPG 

       130        140        150        160        170        180 
AVKLEKEKLE QNPEESQDIK ALQKELEQFA KLLKQKRITL GYTQADVGLT LGVLFGKVFS 

       190        200        210        220        230        240 
QTTICRFEAL QLSFKNMCKL RPLLQKWVEE ADNNENLQEI CKAETLVQAR KRKRTSIENR 

       250        260        270        280        290        300 
VRGNLENLFL QCPKPTLQQI SHIAQQLGLE KDVVRVWFCN RRQKGKRSSS DYAQREDFEA 

       310        320        330        340        350        360 
AGSPFSGGPV SFPLAPGPHF GTPGYGSPHF TALYSSVPFP EGEAFPPVSV TTLGSPMHSN 

Q01860 in FASTA format

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