[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM B), AND VARIANT GLU-78.
TISSUE=Lymphocyte;
DOI=10.1016/0167-4781(92)90125-J; PubMed=1482686 [NCBI, ExPASy, EBI, Israel, Japan]
Tominaga S.,
Yokota T.,
Yanagisawa K.,
Tsukamoto T.,
Takagi T.,
Tetsuka T.;
"Nucleotide sequence of a complementary DNA for human ST2.";
Biochim. Biophys. Acta 1171:215-218(1992).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C), AND VARIANT GLU-78.
DOI=10.1006/bbrc.1999.1469; PubMed=10527832 [NCBI, ExPASy, EBI, Israel, Japan]
Tominaga S.,
Kuroiwa K.,
Tago K.,
Iwahana H.,
Yanagisawa K.,
Komatsu N.;
"Presence and expression of a novel variant form of ST2 gene product in human leukemic cell line UT-7/GM.";
Biochem. Biophys. Res. Commun. 264:14-18(1999).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), AND VARIANTS GLU-78 AND THR-433.
TISSUE=Megakaryoblast;
DOI=10.1006/geno.2000.6269; PubMed=10936050 [NCBI, ExPASy, EBI, Israel, Japan]
Li H.,
Tago K.,
Io K.,
Kuroiwa K.,
Arai T.,
Iwahana H.,
Tominaga S.,
Yanagisawa K.;
"The cloning and nucleotide sequence of human ST2L cDNA.";
Genomics 67:284-290(2000).
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[4]
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SEQUENCE REVISION TO 433.
Yanagisawa K.;
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03466; PubMed=15815621 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W.,
Graves T.A.,
Fulton R.S.,
Fulton L.A.,
Pepin K.H.,
Minx P.,
Wagner-McPherson C.,
Layman D.,
Wylie K.,
Sekhon M.,
Becker M.C.,
Fewell G.A.,
Delehaunty K.D.,
Miner T.L.,
Nash W.E.,
Kremitzki C.,
Oddy L.,
Du H.,
Sun H., ![]()
Bradshaw-Cordum H.,
Ali J.,
Carter J.,
Cordes M.,
Harris A.,
Isak A.,
van Brunt A.,
Nguyen C.,
Du F.,
Courtney L.,
Kalicki J.,
Ozersky P.,
Abbott S.,
Armstrong J.,
Belter E.A.,
Caruso L.,
Cedroni M.,
Cotton M.,
Davidson T.,
Desai A.,
Elliott G.,
Erb T.,
Fronick C.,
Gaige T.,
Haakenson W.,
Haglund K.,
Holmes A.,
Harkins R.,
Kim K.,
Kruchowski S.S.,
Strong C.M.,
Grewal N.,
Goyea E.,
Hou S.,
Levy A.,
Martinka S.,
Mead K.,
McLellan M.D.,
Meyer R.,
Randall-Maher J.,
Tomlinson C.,
Dauphin-Kohlberg S.,
Kozlowicz-Reilly A.,
Shah N.,
Swearengen-Shahid S.,
Snider J.,
Strong J.T.,
Thompson J.,
Yoakum M.,
Leonard S.,
Pearman C.,
Trani L.,
Radionenko M.,
Waligorski J.E.,
Wang C.,
Rock S.M.,
Tin-Wollam A.-M.,
Maupin R.,
Latreille P.,
Wendl M.C.,
Yang S.-P.,
Pohl C.,
Wallis J.W.,
Spieth J.,
Bieri T.A.,
Berkowicz N.,
Nelson J.O.,
Osborne J.,
Ding L.,
Meyer R.,
Sabo A.,
Shotland Y.,
Sinha P.,
Wohldmann P.E.,
Cook L.L.,
Hickenbotham M.T.,
Eldred J.,
Williams D.,
Jones T.A.,
She X.,
Ciccarelli F.D.,
Izaurralde E.,
Taylor J.,
Schmutz J.,
Myers R.M.,
Cox D.R.,
Huang X.,
McPherson J.D.,
Mardis E.R.,
Clifton S.W.,
Warren W.C.,
Chinwalla A.T.,
Eddy S.R.,
Marra M.A.,
Ovcharenko I.,
Furey T.S.,
Miller W.,
Eichler E.E.,
Bork P.,
Suyama M.,
Torrents D.,
Waterston R.H.,
Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.";
Nature 434:724-731(2005).
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[6]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
TISSUE=Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[7]
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PROTEIN SEQUENCE OF 19-33.
DOI=10.1110/ps.04682504; PubMed=15340161 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Z.,
Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
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[8]
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SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
DOI=10.1006/bbrc.2001.5306; PubMed=11478810 [NCBI, ExPASy, EBI, Israel, Japan]
Tago K.,
Noda T.,
Hayakawa M.,
Iwahana H.,
Yanagisawa K.,
Yashiro T.,
Tominaga S.;
"Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V.";
Biochem. Biophys. Res. Commun. 285:1377-1383(2001).
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[9]
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FUNCTION, AND SUBUNIT.
DOI=10.1016/j.immuni.2005.09.015; PubMed=16286016 [NCBI, ExPASy, EBI, Israel, Japan]
Schmitz J.,
Owyang A.,
Oldham E.,
Song Y.,
Murphy E.,
McClanahan T.K.,
Zurawski G.,
Moshrefi M.,
Qin J.,
Li X.,
Gorman D.M.,
Bazan J.F.,
Kastelein R.A.;
"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines.";
Immunity 23:479-490(2005).
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[10]
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SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
DOI=10.1186/gb-2004-5-2-r8; PubMed=14759258 [NCBI, ExPASy, EBI, Israel, Japan]
Hillman R.T.,
Green R.E.,
Brenner S.E.;
"An unappreciated role for RNA surveillance.";
Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004).
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- FUNCTION: Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.
- SUBUNIT: Interacts with MYD88, IRAK1, IRAK4, and TRAF6.
- INTERACTION:
O95760:IL33; NbExp=2; IntAct=EBI-993762, EBI-724057;
Q9NWZ3:IRAK4; NbExp=1; IntAct=EBI-993762, EBI-448378;
Q99836:MYD88; NbExp=1; IntAct=EBI-993762, EBI-447677;
Q9Y4K3:TRAF6; NbExp=1; IntAct=EBI-993762, EBI-359276;
- SUBCELLULAR LOCATION: Isoform C: Cell membrane.
- SUBCELLULAR LOCATION: Isoform B: Secreted.
- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
- ALTERNATIVE PRODUCTS:
3 named isoforms [FASTA] produced by alternative splicing.
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| Name | C |
| Synonyms | ST2V |
| Isoform ID | Q01638-3 |
| Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. |
| Features which should be applied to build the isoform sequence: VSP_002664, VSP_002665. |
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- TISSUE SPECIFICITY: Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Expression of isoform A is prevalent in the lung, testis, placenta, stomach and colon. However, isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle.
- SIMILARITY: Belongs to the interleukin-1 receptor family.
- SIMILARITY: Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
- SIMILARITY: Contains 1 TIR domain.
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