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UniProtKB/Swiss-Prot entry Q00024

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PPO1_AGABI
Primary accession number Q00024
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 47)
Name and origin of the protein
Protein name Polyphenol oxidase
Synonyms PPO
EC 1.10.3.1
Catechol oxidase
Gene name
Name: ppo1
From
Agaricus bisporus (Common mushroom) [TaxID: 5341] 
Taxonomy Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes; Agaricomycetidae; Agaricales; Agaricaceae; Agaricus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Horst U1;
DOI=10.1007/s00253-002-1194-2; PubMed=12743763 [NCBI, ExPASy, EBI, Israel, Japan]
Wichers H., Recourt K., Hendriks M., Ebbelaar C.E.M., Biancone G., Hoeberichts F., Mooibroek H., Soler-Rivas C.;
"Cloning, expression and characterisation of two tyrosinase cDNAs from Agaricus bisporus.";
Appl. Microbiol. Biotechnol. 61:336-341(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X85113; CAA59432.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S53017; S53017.
3D structure databases
ModBase Q00024.
Ontologies
GO
GO:0004097; Molecular function: catechol oxidase activity (inferred from electronic annotation from EC).
GO:0005507; Molecular function: copper ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR008922; Di-copper_centre.
IPR016216; Monophenol_mOase_fun.
IPR002227; Tyrosinase.
Graphical view of domain structure.
Gene3D G3DSA:1.10.1280.10; Di-copper_centre; 1.
Pfam PF00264; Tyrosinase; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000340; MPO_fungal; 1.
PRINTS PR00092; TYROSINASE.
PROSITE PS00497; TYROSINASE_1; 1.
PS00498; TYROSINASE_2; 1.
ProtoNet Q00024.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Copper; Metal-binding; Oxidoreductase; Thioether bond.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   568  568     Polyphenol oxidase. PRO_0000186740
METAL   57    57        Copper A (By similarity). 
METAL   85    85        Copper A (By similarity). 
METAL   94    94        Copper A (By similarity). 
METAL   257   257        Copper B (By similarity). 
METAL   261   261        Copper B (By similarity). 
METAL   286   286        Copper B (By similarity). 
CROSSLNK   83    85        2'-(S-cysteinyl)-histidine (Cys-His) (By similarity). 
Sequence information
Length: 568 AA [This is the length of the unprocessed precursor] Molecular weight: 63898 Da [This is the MW of the unprocessed precursor] CRC64: F5CBADB73533685A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSHLLVSPLG GGVQPRLEIN NFVKNDRQFS LYVQALDRMY ATPQNETASY FQVAGVHGYP 

        70         80         90        100        110        120 
LIPFDDAVGP TEFSPFDQWT GYCTHGSTLF PTWHRPYVLI LEQILSGHAQ QIADTYTVNK 

       130        140        150        160        170        180 
SEWKKAATEF RHPYWDWASN SVPPPEVISL PKVTITTPNG QKTSVANPLM RYTFNSVNDG 

       190        200        210        220        230        240 
GFYGPYNQWD TTLRQPDSTG VNAKDNVNRL KSVLKNAQAS LTRATYDMFN RVTTWPHFSS 

       250        260        270        280        290        300 
HTPASGGSTS NSIEAIHDNI HVLVGGNGHM SDPSVAPFDP IFFLHHANVD RLIALWSAIR 

       310        320        330        340        350        360 
YDVWTSPGDA QFGTYTLRYK QSVDESTDLA PWWKTQNEYW KSNELRSTES LGYTYPEFVG 

       370        380        390        400        410        420 
LDMYNKDAVN KTISRKVAQL YGPQRGGQRS LVEDLSNSHA RRSQRPAKRS RLGQLLKGLF 

       430        440        450        460        470        480 
SDWSAQIKFN RHEVGQSFSV CLFLGNVPED PREWLVSPNL VGARHAFVRS VKTDHVAEEI 

       490        500        510        520        530        540 
GFIPINQWIA EHTGLPSFAV DLVKPLLAQG LQWRVLLADG TPAELDSLEV TILEVPSELT 

       550        560 
DDEPNPRSRP PRYHKDITHG KRGGCREA
Q00024 in FASTA format

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