[1]	PROTEIN SEQUENCE. TISSUE=Leaf; PubMed=2753596 [NCBI, ExPASy, EBI, Israel, Japan] Montecucchi P.-C., Lazzarini A.M., Barbieri L., Stirpe F., Soria M., Lappi D.; "N-terminal sequence of some ribosome-inactivating proteins."; Int. J. Pept. Protein Res. 33:263-267(1989).

Comments

FUNCTION: Ribosome-inactivating protein of type 1, inhibits protein synthesis in animal cells (By similarity).
CATALYTIC ACTIVITY: Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
SIMILARITY: Belongs to the ribosome-inactivating protein family. Type 1 RIP subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

S16331; S16331.

3D structure databases

Ontologies

GO:0030598;	Molecular function: rRNA N-glycosylase activity (inferred from electronic annotation from InterPro).
GO:0006952;	Biological process: defense response (inferred from electronic annotation from UniProtKB-KW).
GO:0017148;	Biological process: negative regulation of translation (inferred from electronic annotation from InterPro).
GO:0009405;	Biological process: pathogenesis (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

PS00275; SHIGA_RICIN; PARTIAL.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; Hydrolase; Plant defense; Protein synthesis inhibitor; Toxin.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 >40`	`>40`	`Ribosome-inactivating protein saporin-1.`	`PRO_0000221411`
`NON_TER`	`40 40`

Sequence information

Length: 40 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 4625 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: F4615857A9871BF2 [This is a checksum on the sequence]

        10         20         30         40 
VIIYELNLQG TTKAQYSTIL KQLRDDIKDP NLXYGXXDYS

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools