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[1]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6;
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] OF 70-750.
TISSUE=Brain;
DOI=10.1007/BF00350899; PubMed=7719031 [NCBI, ExPASy, EBI, Israel, Japan]
Duclos F.,
Koenig M.;
"Comparison of primary structure of a neuron-specific protein, X11, between human and mouse.";
Mamm. Genome 6:57-58(1995).
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[3]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209, AND MASS SPECTROMETRY.
TISSUE=Brain;
DOI=10.1074/mcp.M400085-MCP200; PubMed=15345747 [NCBI, ExPASy, EBI, Israel, Japan]
Ballif B.A.,
Villen J.,
Beausoleil S.A.,
Schwartz D.,
Gygi S.P.;
"Phosphoproteomic analysis of the developing mouse brain.";
Mol. Cell. Proteomics 3:1093-1101(2004).
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- FUNCTION: Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.
- SUBUNIT: Part of a multimeric complex containing STXBP1 and syntaxin-1. Binds to the cytoplasmic domain of amyloid protein beta, and to the nuclear factor NF-kappa-B/p65 via its PDZ domain. Interacts with the amino-terminal domain of APBA2BP (By similarity).
- INTERACTION:
P12023:App; NbExp=1; IntAct=EBI-81669, EBI-78814;
- TISSUE SPECIFICITY: Specifically expressed in neurons, predominantly of the cerebellum, hippocampus, and spinal cord. Lesser extent in neurons of the cerebral cortex and anterior thalmic nuclei.
- DOMAIN: Composed of an N-terminal domain that binds STXBP1, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.
- SIMILARITY: Contains 2 PDZ (DHR) domains.
- SIMILARITY: Contains 1 PID domain.
- CAUTION: Was originally (PubMed:15489334) thought to be the ortholog of human X11 (APBA1).
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 750 AA [This is the length of the unprocessed precursor] |
Molecular weight: 82758 Da [This is the MW of the unprocessed precursor] |
CRC64: FC231C966DB467DE [This is a checksum on the sequence] |
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10 20 30 40 50 60
MAHRKRQSTA SSMLDHRARP GPIPHDQEPE SEDTELPLES YVPTGLELGT LRPESPTPEE
70 80 90 100 110 120
QECHNHSPDG DSSSDYVNNT SEEEDYDEGL PEEEEGVTYY IRYCPEDDSY LEGMDCNGEE
130 140 150 160 170 180
YIAHGAHPVD TDECQEAVED WTDSVGPHTH SHGAENSQEY PDGHLPIPED DPTVLEVHDQ
190 200 210 220 230 240
EEDGHYCSSK ESYQDYYPPE TNGNTGGASP YRMRRGDGDL EEQEEDIDQI VAEIKMSLSM
250 260 270 280 290 300
TSITSASEAS PEHMPELDPG DSTEACPPSD TGHGPGRQEA RPKSLNLPPE VKHPGDLQRG
310 320 330 340 350 360
LKTKTRTPEE RPKWPQEQVC NGLEQPRKQQ RSDLNGPTDN NNIPETKKVA SFPSFVAVPG
370 380 390 400 410 420
PCEAEDLIDG IIFAANYLGS TQLLSERNPS KNIRMMQAQE AVSRVKRMQK AAKIKKKANS
430 440 450 460 470 480
EGDAQTLTEV DLFISTQRIK VLNADTQETM MDHALRTISY IADIGNIVVL MARRRMPRSA
490 500 510 520 530 540
SQDCIETTPG AQEGKKQYKM ICHVFESEDA QLIAQSIGQA FSVAYQEFLR ANGINPEDLS
550 560 570 580 590 600
QKEYSDIINT QEMYNDDLIH FSNSENCKEL QLEKHKGEIL GVVVVESGWG SILPTVILAN
610 620 630 640 650 660
MMNGGPAARS GKLSIGDQIM SINGTSLVGL PLATCQGIIK GLKNQTQVKL NIVSCPPVTT
670 680 690 700 710 720
VLIKRPDLKY QLGFSVQNGI ICSLMRGGIA ERGGVRVGHR IIEINGQSVV ATAHEKIVQA
730 740 750
LSNSVGEIHM KTMPAAMFRL LTGQETPLYI
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P98084 in FASTA format |
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ExPASy Home page
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