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UniProtKB/Swiss-Prot entry P97872

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FMO5_MOUSE
Primary accession number P97872
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 60)
Name and origin of the protein
Protein name Dimethylaniline monooxygenase [N-oxide-forming] 5
Synonyms EC 1.14.13.8
Hepatic flavin-containing monooxygenase 5
FMO 5
Dimethylaniline oxidase 5
Gene name
Name: Fmo5
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=CD-1;
TISSUE=Liver;
PubMed=9580872 [NCBI, ExPASy, EBI, Israel, Japan]
Cherrington N.J., Falls J.G., Rose R.L., Clements K.M., Philpot R.M., Levi P.E., Hodgson E.;
"Molecular cloning, sequence, and expression of mouse flavin-containing monooxygenases 1 and 5 (FMO1 and FMO5).";
J. Biochem. Mol. Toxicol. 12:205-212(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U90535; AAB50013.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
UniGene Mm.385180
3D structure databases
ModBase P97872.
PTM databases
PhosphoSite P97872; -.
Organism-specific databases
MGI MGI:1310004; Fmo5.
Gene expression databases
ArrayExpress P97872; -.
CleanEx MM_FMO5; -.
GermOnline ENSMUSG00000028088; Mus musculus.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0031227; Cellular component: intrinsic to endoplasmic reticulum membrane (inferred from electronic annotation from InterPro).
GO:0005792; Cellular component: microsome (inferred from electronic annotation from InterPro).
GO:0050660; Molecular function: FAD binding (inferred from electronic annotation from InterPro).
GO:0004499; Molecular function: flavin-containing monooxygenase activity (inferred from electronic annotation from InterPro).
GO:0050661; Molecular function: NADP binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR012143; dManiline_mOase.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR000960; Flavin_mOase.
IPR002257; Flavin_mOase_5.
Graphical view of domain structure.
Pfam PF00743; FMO-like; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000332; FMO; 1.
PRINTS PR00368; FADPNR.
PR00370; FMOXYGENASE.
PR01125; FMOXYGENASE5.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
ProtoNet P97872.
Genome annotation databases
Ensembl ENSMUSG00000028088; Mus musculus. [Contig view]
Phylogenomic databases
HOGENOM P97872; -.
HOVERGEN P97872; -.
Other
SOURCE Fmo5; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Endoplasmic reticulum; FAD; Flavoprotein; Membrane; Methylation; Microsome; Monooxygenase; NADP; Oxidoreductase; Transmembrane.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   533  532     Dimethylaniline monooxygenase [N-oxide-forming] 5. PRO_0000147666
NP_BIND   10    15  6     FAD (Potential). 
NP_BIND   192   197  6     NADP (By similarity). 
MOD_RES   2     2        N-acetylalanine (By similarity). 
MOD_RES   5     5        Omega-N-methylated arginine (By similarity). 
Sequence information
Length: 533 AA [This is the length of the unprocessed precursor] Molecular weight: 60030 Da [This is the MW of the unprocessed precursor] CRC64: 9C749652A7F823DE [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAKKRIAVIG AGASGLTCIK CCLEEGLEPV CFERSGDIGG LWRFQEAPEE GRASIYQSVV 

        70         80         90        100        110        120 
INTSKEMMCF SDYPIPDHYP NYMHNSQVLE YFRMYAKEFD LLKYIQFKTT VCSVKKQPDF 

       130        140        150        160        170        180 
STSGQWQVVT ECEGKQQVDV FDGVLVCTGH HTDAHLPLES FPGIEKFKGK YFHSRDYKNP 

       190        200        210        220        230        240 
VEFTGKRVIV IGIGNSGGDL AVEISHTAKQ VFLSTRRGAW ILNRVGKHGY PIDLLLSSRI 

       250        260        270        280        290        300 
MYYLSRICGP SLKNNYMEKQ MNQRFDHEMF GLKPKHRALS QHPTVNDDLP NRIIAGLVKV 

       310        320        330        340        350        360 
KGNVKEFTET AAIFEDGSRE DGIDVVIFAT GYSFAFPFLE DSVKVVKNKV SLYKKVFPPN 

       370        380        390        400        410        420 
LEKPTLAIIG LIQPLGAIMP ISELQGRWAT QVFKGLKKLP SQSEMMAEIN KAREEMAKRY 

       430        440        450        460        470        480 
VDSQRHTIQG DYIDTMEEIA DLVGVRPNIQ PLVFTDPRLA LRLLLGPCTP VQYRLQGPGK 

       490        500        510        520        530 
WAGARKTILT TEDRVRKPLM TRVVERDSSG GSLVTVRVLM LAVAFFAVIL AYF
P97872 in FASTA format

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