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UniProtKB/Swiss-Prot entry P97528

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CNTN6_RAT
Primary accession number P97528
Secondary accession numbers None
Integrated into Swiss-Prot on November 23, 2004
Sequence was last modified on May 1, 1997 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 56)
Name and origin of the protein
Protein name Contactin-6 [Precursor]
Synonym Neural recognition molecule NB-3
Gene name
Name: Cntn6
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=Wistar;
TISSUE=Brain;
DOI=10.1016/S0304-3940(96)13156-6; PubMed=8945756 [NCBI, ExPASy, EBI, Israel, Japan]
Ogawa J., Kaneko H., Masuda T., Nagata S., Hosoya H., Watanabe K.;
"Novel neural adhesion molecules in the contactin/F3 subgroup of the immunoglobulin superfamily: isolation and characterization of cDNAs from rat brain.";
Neurosci. Lett. 218:173-176(1996).
[2]
 ERRATUM.
Ogawa J., Kaneko H., Masuda T., Nagata S., Hosoya H., Watanabe K.;
Neurosci. Lett. 221:221-223(1997).
[3]
 GPI-ANCHOR.
DOI=10.1002/neu.10222; PubMed=12884264 [NCBI, ExPASy, EBI, Israel, Japan]
Takeda Y., Akasaka K., Lee S., Kobayashi S., Kawano H., Murayama S., Takahashi N., Hashimoto K., Kano M., Asano M., Sudo K., Iwakura Y., Watanabe K.;
"Impaired motor coordination in mice lacking neural recognition molecule NB-3 of the contactin/F3 subgroup.";
J. Neurobiol. 56:252-265(2003).
[4]
 FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND INTERACTION WITH NOTCH1.
DOI=10.1074/jbc.M313505200; PubMed=15082708 [NCBI, ExPASy, EBI, Israel, Japan]
Cui X.-Y., Hu Q.-D., Tekaya M., Shimoda Y., Ang B.-T., Nie D.-Y., Sun L., Hu W.-P., Karsak M., Duka T., Takeda Y., Ou L.-Y., Dawe G.S., Yu F.-G., Ahmed S., Jin L.-H., Schachner M., Watanabe K., Arsenijevic Y., Xiao Z.-C.;
"NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes.";
J. Biol. Chem. 279:25858-25865(2004).
Comments
  • FUNCTION: Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. May be involved in motor coordination.
  • SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
  • TISSUE SPECIFICITY: Specifically expressed in neuronal cells. In brain, it is expressed in spinal cord, cerebrum and cerebellum. At E17, it is expressed hippocampus, cerebellum, and the brain stem. Strongly expressed after birth with a maximum level between postnatal day 0 and 21, which corresponds to the time frame of oligodendrogliogenesis.
  • DEVELOPMENTAL STAGE: Expressed at low level during embryogenesis. Highly expressed after birth.
  • SIMILARITY: Belongs to the immunoglobulin superfamily. Contactin family.
  • SIMILARITY: Contains 4 fibronectin type-III domains.
  • SIMILARITY: Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D87248; BAA13320.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_037357.1; -.
UniGene Rn.10644
3D structure databases
HSSP Q9UQH9; 1IIL. [HSSP ENTRY / PDB]
ModBase P97528.
Organism-specific databases
RGD 62008; Cntn6.
Gene expression databases
ArrayExpress P97528; -.
GermOnline ENSRNOG00000032517; Rattus norvegicus.
Family and domain databases
InterPro IPR008957; Fibronectin_typ-III-like_fold.
IPR003961; FN_III.
IPR013151; Ig.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.30; FN_III-like; 2.
G3DSA:2.60.40.10; Ig-like_fold; 6.
Pfam PF00041; fn3; 4.
PF07679; I-set; 3.
PF00047; ig; 3.
Pfam graphical view of domain structure.
SMART SM00060; FN3; 4.
SM00409; IG; 1.
SM00408; IGc2; 5.
SMART graphical view of domain structure.
PROSITE PS50853; FN3; 4.
PS50835; IG_LIKE; 6.
PROSITE graphical view of domain structure (profiles).
BLOCKS P97528.
Genome annotation databases
Ensembl ENSRNOG00000032517; Rattus norvegicus. [Contig view]
GeneID 27256; -.
KEGG rno:27256; -.
Phylogenomic databases
HOVERGEN P97528; -.
Other
ProtoNet P97528.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell adhesion; Cell membrane; Glycoprotein; GPI-anchor; Immunoglobulin domain; Lipoprotein; Membrane; Notch signaling pathway; Repeat; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
SIGNAL   1     19  19     Potential. 
CHAIN   20    999  980     Contactin-6. PRO_0000014731
PROPEP   1000   1028  29     Removed in mature form (Potential). PRO_0000014732
DOMAIN   32    117  86     Ig-like C2-type 1. 
DOMAIN   122    208  87     Ig-like C2-type 2. 
DOMAIN   227    308  82     Ig-like C2-type 3. 
DOMAIN   318    402  85     Ig-like C2-type 4. 
DOMAIN   408    495  88     Ig-like C2-type 5. 
DOMAIN   499    587  89     Ig-like C2-type 6. 
DOMAIN   597    693  97     Fibronectin type-III 1. 
DOMAIN   700    796  97     Fibronectin type-III 2. 
DOMAIN   802    897  96     Fibronectin type-III 3. 
DOMAIN   903    992  90     Fibronectin type-III 4. 
LIPID   999    999        GPI-anchor amidated serine (Potential). 
CARBOHYD   65     65        N-linked (GlcNAc...) (Potential). 
CARBOHYD   193    193        N-linked (GlcNAc...) (Potential). 
CARBOHYD   368    368        N-linked (GlcNAc...) (Potential). 
CARBOHYD   377    377        N-linked (GlcNAc...) (Potential). 
CARBOHYD   468    468        N-linked (GlcNAc...) (Potential). 
CARBOHYD   659    659        N-linked (GlcNAc...) (Potential). 
CARBOHYD   765    765        N-linked (GlcNAc...) (Potential). 
CARBOHYD   860    860        N-linked (GlcNAc...) (Potential). 
CARBOHYD   865    865        N-linked (GlcNAc...) (Potential). 
CARBOHYD   895    895        N-linked (GlcNAc...) (Potential). 
CARBOHYD   931    931        N-linked (GlcNAc...) (Potential). 
CARBOHYD   956    956        N-linked (GlcNAc...) (Potential). 
CARBOHYD   957    957        N-linked (GlcNAc...) (Potential). 
DISULFID   50    100        By similarity. 
DISULFID   144    196        By similarity. 
DISULFID   249    297        By similarity. 
DISULFID   339    386        By similarity. 
DISULFID   431    479        By similarity. 
DISULFID   521    577        By similarity. 
Sequence information
Length: 1028 AA [This is the length of the unprocessed precursor] Molecular weight: 114065 Da [This is the MW of the unprocessed precursor] CRC64: 47EFD8A370CF4923 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRLLWKLVIL LPLINSCAGE SRFTRPIFIQ EPQDVIFPLD LSRSEIILSC TASGYPSPHY 

        70         80         90        100        110        120 
RWKQNGTDID FSMTYHYRLD GGSLAISSPR TDQDIGIYQC LATNPVGTIL SRKAKLQFAY 

       130        140        150        160        170        180 
IEDFETKSRS TVSVREGQGV VLLCGPPPHF GELSYDWTFN DNPLYVQEDK RRFVSQNTGN 

       190        200        210        220        230        240 
LYIAKVEPSD VGNYTCFVTN KEAHRSVQGP PTPLVQRTDG VMGEYEPKIE VRFPETIQAA 

       250        260        270        280        290        300 
KDSSVKLECF ALGNPVPDIS WRRLDGSPMP GKVKYSNSQA TLEIPKFQQE DEGFYECVAG 

       310        320        330        340        350        360 
NLRGRNLAKG QLIFYAPPEW EQKIQNTYLS IYDSLFWECK ASGNPNPSYT WLKNGERLNT 

       370        380        390        400        410        420 
EERIQTENGT LIITMLNVSD SGIYQCAAEN KYQTIYANAE LRVLASAPDF SKNPIKKISV 

       430        440        450        460        470        480 
VQVGGDISIE CKPNAFPKAS ISWKRGTENL KQSKRVFFLE DGSLKICNVT RSDAGSYTCV 

       490        500        510        520        530        540 
ATNQFGNGKS SGSLIVKERT VITVPPSKMD VTVGESIVLP CQVSHDPTME VLFVWYFNGD 

       550        560        570        580        590        600 
VIDLKKGVAH FERIGGESVG DLMIRNIQLG HSGKYLCTVQ TTLERLSAVA DIIVRGPPGP 

       610        620        630        640        650        660 
PEDVKVEHIS STTSQLSWRP GPDNNSPIQI FTIQTRTPFS VGWQAVATVP EILNGQTYNA 

       670        680        690        700        710        720 
TVIGLSPWVE YEFRVVAGNN IGIGEPSKPS ELLRTKASIP NVAPVNINGG GGSRSELVIT 

       730        740        750        760        770        780 
WEPIPEELQN GEGFGYIIMF RPVGSTTWMK EKVALVESSK FIYRNESIMP LSPFEVKVGV 

       790        800        810        820        830        840 
YNNEGEGSLS TVSIVYSGED EPRLAPRGTS VQSFSASDME VSWNAIAWNR NTGRVLGYEV 

       850        860        870        880        890        900 
LYWTDNSKES MIGKIRVSGN VTTKNITGLR ANTIYFASVR AYNTAGTGPS SPPVNVTTKK 

       910        920        930        940        950        960 
SPPSQPPANI AWKLSNSKLC LNWEHVKTME NESEVLGYKI LYRQNRQSKT HVLETNNTSA 

       970        980        990       1000       1010       1020 
ELLVPFEEDY LIEIRTVSDG GDGSSSEEIR IPKMSSLSSV GVQILKPSTQ FLTMVGFFYC 


FVIQPLSR
P97528 in FASTA format

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