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UniProtKB/Swiss-Prot entry P80521

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PORA_METBF
Primary accession number P80521
Secondary accession number Q46DS4
Integrated into Swiss-Prot on February 1, 1996
Sequence was last modified on January 10, 2006 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 45)
Name and origin of the protein
Protein name Pyruvate synthase subunit porA
Synonyms EC 1.2.7.1
Pyruvate oxidoreductase alpha chain
POR
Pyruvic-ferredoxin oxidoreductase subunit alpha
Gene name
Name: porA
OrderedLocusNames: Mbar_A1000
From
Methanosarcina barkeri (strain Fusaro / DSM 804) [TaxID: 269797] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1128/JB.00810-06; PubMed=16980466 [NCBI, ExPASy, EBI, Israel, Japan]
Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.;
"The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes.";
J. Bacteriol. 188:7922-7931(2006).
[2]
 PROTEIN SEQUENCE OF 1-38.
PubMed=8620891 [NCBI, ExPASy, EBI, Israel, Japan]
Bock A.-K., Kunow J., Glasemacher J., Schoenheit P.;
"Catalytic properties, molecular composition and sequence alignments of pyruvate: ferredoxin oxidoreductase from the methanogenic archaeon Methanosarcina barkeri (strain Fusaro).";
Eur. J. Biochem. 237:35-44(1996).
Comments
  • CATALYTIC ACTIVITY: Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+.
  • SUBUNIT: Heterotetramer of one alpha, one beta, one delta and one gamma chain.
  • MISCELLANEOUS: It also catalyzes the oxidation of 2-oxobutyrate.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000099; AAZ69968.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S65416; S65416.
RefSeq YP_304548.1; -.
3D structure databases
ModBase P80521.
Enzyme and pathway databases
BioCyc MBAR269797:MBAR_A1000-MON; -.
Ontologies
GO
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0019164; Molecular function: pyruvate synthase activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
IPR015941; Transketolase_C-like.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.920; Transketo_C_like; 1.
Pfam PF01855; POR_N; 1.
Pfam graphical view of domain structure.
ProtoNet P80521.
Genome annotation databases
GeneID 3626883; -.
GenomeReviews CP000099_GR; Mbar_A1000.
KEGG mba:Mbar_A1000; -.
NMPDR fig|269797.3.peg.1011; -.
Phylogenomic databases
HOGENOM P80521; -.
Genome annotation databases
CMR P80521; Mbar_A1000.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Direct protein sequencing; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   402  402     Pyruvate synthase subunit porA. PRO_0000097125
Sequence information
Length: 402 AA [This is the length of the unprocessed precursor] Molecular weight: 44503 Da [This is the MW of the unprocessed precursor] CRC64: D7DA8CA3AF2143B6 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MIDPAYRKKM VVVEGSYAVA HSAKVCRPNV ISAYPITPQT HIVEHLSQFM ADGEIPNCEY 

        70         80         90        100        110        120 
VNVEAEFSAI SALIGASAVG ARTYSATTSQ GLLLMHEALF NTSGMRLPVV MTVANRAVSA 

       130        140        150        160        170        180 
PINIWNDHQD AIAQRDTGWM QLYVEDVQEA CDTLPQLYKI AEDNEIMVPG MVCMDGFILS 

       190        200        210        220        230        240 
HVYEPVVLLE QDLTDNFLPP FQPEDILDPE DPKTFGAFAS PDTYEEFRYL HEQAMQKALP 

       250        260        270        280        290        300 
KIEATAKEFE EVYGRYHGGL IDGYMLDDAE IVVMAMGSIL GTVKDVVDKY RAKGEKIGVL 

       310        320        330        340        350        360 
KVRSFRPFPK EQICKAVKNA HAVVVLDKNI SIGTNEGALF TETKSCLYNS KVRVPVIGYT 

       370        380        390        400 
IGHGGRDIPV ESIAKVIEET KKVAKSGITI ESQFMDLKEE LL
P80521 in FASTA format

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