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UniProtKB/Swiss-Prot entry P78358


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CTG1B_HUMAN
Primary accession number P78358
Secondary accession numbers A1L417 Q7LBY4 Q9NY13
Integrated into Swiss-Prot on December 15, 1998
Sequence was last modified on May 1, 1997 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 64)
Name and origin of the protein
Protein name Cancer/testis antigen 1
Synonyms L antigen family member 2
LAGE-2
Autoimmunogenic cancer/testis antigen NY-ESO-1
Cancer/testis antigen 6.1
CT6.1
Gene names
Name: CTAG1A
Synonyms: CTAG, CTAG1, ESO1, LAGE2, LAGE2A
and
Name: CTAG1B
Synonyms: LAGE2B
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
DOI=10.1073/pnas.94.5.1914; PubMed=9050879 [NCBI, ExPASy, EBI, Israel, Japan]
Chen Y.-T., Scanlan M.J., Sahin U., Tuereci O., Gure A.O., Tsang S., Williamson B., Stockert E., Pfreundschuh M., Old L.J.;
"A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening.";
Proc. Natl. Acad. Sci. U.S.A. 94:1914-1918(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Melanoma;
DOI=10.1002/(SICI)1097-0215(19980610)76:6<903::AID-IJC22>3.0.CO;2-1; PubMed=9626360 [NCBI, ExPASy, EBI, Israel, Japan]
Lethe B.G., Lucas S., Michaux L., De Smet C., Godelaine D., Serrano A., De Plaen E., Boon T.;
"LAGE-1, a new gene with tumor specificity.";
Int. J. Cancer 76:903-908(1998).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=9759882 [NCBI, ExPASy, EBI, Israel, Japan]
Wang R.-F., Johnston S.L., Zeng G., Topalian S.L., Schwartzentruber D.J., Rosenberg S.A.;
"A breast and melanoma-shared tumor antigen: T cell responses to antigenic peptides translated from different open reading frames.";
J. Immunol. 161:3598-3606(1998).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=10523621 [NCBI, ExPASy, EBI, Israel, Japan]
De Smet C., Lurquin C., Lethe B.G., Martelange V., Boon T.;
"DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter.";
Mol. Cell. Biol. 19:7327-7335(1999).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1093/hmg/10.22.2557; PubMed=11709543 [NCBI, ExPASy, EBI, Israel, Japan]
Aradhya S., Bardaro T., Galgoczy P., Yamagata T., Esposito T., Patlan H., Ciccodicola A., Kenwrick S., Platzer M., D'Urso M., Nelson D.L.;
"Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes.";
Hum. Mol. Genet. 10:2557-2567(2001).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03440; PubMed=15772651 [NCBI, ExPASy, EBI, Israel, Japan]
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence of the human X chromosome.";
Nature 434:325-337(2005).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[9]
NUCLEOTIDE SEQUENCE [MRNA] OF 27-180 (ISOFORM 2).
Lethe B.G.;
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
[10]
TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
PubMed=12065688 [NCBI, ExPASy, EBI, Israel, Japan]
Satie A.P., Rajpert-De Meyts E., Spagnoli G.C., Henno S., Olivo L., Jacobsen G.K., Rioux-Leclercq N., Jegou B., Samson M.;
"The cancer-testis gene, NY-ESO-1, is expressed in normal fetal and adult testes and in spermatocytic seminomas and testicular carcinoma in situ.";
Lab. Invest. 82:775-780(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U87459; AAB49693.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ003149; CAA05908.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF038567; AAD05202.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ275977; CAB76943.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF277315; AAL27013.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF277315; AAL27014.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CH471172; EAW72674.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC130362; AAI30363.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC130364; AAI30365.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ275978; CAB76945.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001318.1; -.
NP_640343.1; -.
UniGene Hs.534310
3D structure databases
PDB
2BNR; X-ray; 1.90 A; C=157-165.[ExPASy / RCSB / EBI]
2F53; X-ray; 2.10 A; C=157-165.[ExPASy / RCSB / EBI]
2F54; X-ray; 2.70 A; C/H=157-165.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 2BNR; -.
2F53; -.
2F54; -.
ModBase P78358.
Protein-protein interaction databases
IntAct P78358; -.
Organism-specific databases
H-InvDB HIX0056122; -.
HIX0077128; -.
HGNC HGNC:24198; CTAG1A.
HGNC:2491; CTAG1B.
GenAtlas CTAG1A.
HPA CAB013061; -.
CAB015453; -.
MIM 300156; gene. [NCBI / EBI]
300657; gene. [NCBI / EBI]
PharmGKB PA26993; -.
GeneCards P78358.
Gene expression databases
CleanEx HS_CTAG1A; -.
HS_CTAG1B; -.
GermOnline ENSG00000183678; Homo sapiens.
ENSG00000184033; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from direct assay from LIFEdb).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR015419; Pcc1.
Graphical view of domain structure.
Pfam PF09341; Pcc1; 1.
Pfam graphical view of domain structure.
BLOCKS P78358.
Genome annotation databases
Ensembl ENSG00000183678; Homo sapiens. [Contig view]
ENSG00000184033; Homo sapiens. [Contig view]
GeneID 1485; -.
246100; -.
KEGG hsa:1485; -.
hsa:246100; -.
Phylogenomic databases
HOGENOM P78358; -.
HOVERGEN P78358; -.
Other
LinkHub P78358; -.
SOURCE CTAG1A; Homo sapiens.
ProtoNet P78358.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Alternative splicing; Cytoplasm.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   180  180     Cancer/testis antigen 1. PRO_0000218922
COMPBIAS   5    82  78     Gly-rich. 
VAR_SEQ   135   180        IRLTAADHRQLQLSISSCLQQLSLLMWITQCFLPVFLAQP PSGQRR -> MSVQDQDRDGAWVGGGHSVAGWGLGSAYTPRSGC (in isoform 2). VSP_028548
STRAND   160   160  1      
Sequence information
Length: 180 AA [This is the length of the unprocessed precursor] Molecular weight: 17992 Da [This is the MW of the unprocessed precursor] CRC64: B122C5C2C8BE1569 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MQAEGRGTGG STGDADGPGG PGIPDGPGGN AGGPGEAGAT GGRGPRGAGA ARASGPGGGA 

        70         80         90        100        110        120 
PRGPHGGAAS GLNGCCRCGA RGPESRLLEF YLAMPFATPM EAELARRSLA QDAPPLPVPG 

       130        140        150        160        170        180 
VLLKEFTVSG NILTIRLTAA DHRQLQLSIS SCLQQLSLLM WITQCFLPVF LAQPPSGQRR 

P78358 in FASTA format

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View entry in raw text format (no links)
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