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UniProtKB/Swiss-Prot entry P71756

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HEMN_MYCTU
Primary accession number P71756
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on February 1, 1997 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 64)
Name and origin of the protein
Protein name Probable oxygen-independent coproporphyrinogen III oxidase
Synonyms Coproporphyrinogenase
Coprogen oxidase
EC 1.3.99.22
Gene name
Name: hemN
OrderedLocusNames: Rv2388c, MT2457
ORFNames: MTCY253.33
From
Mycobacterium tuberculosis [TaxID: 1773] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 25618 / H37Rv;
DOI=10.1038/31159; PubMed=9634230 [NCBI, ExPASy, EBI, Israel, Japan]
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.";
Nature 393:537-544(1998).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CDC 1551 / Oshkosh;
DOI=10.1128/JB.184.19.5479-5490.2002; PubMed=12218036 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.";
J. Bacteriol. 184:5479-5490(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX842579; CAB03737.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE000516; AAK46752.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR G70681; G70681.
RefSeq NP_216904.1; -.
NP_336938.1; -.
3D structure databases
ModBase P71756.
Organism-specific databases
TubercuList Rv2388c; -.
Ontologies
GO
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding (inferred from electronic annotation from UniProtKB-KW).
GO:0051989; Molecular function: coproporphyrinogen dehydrogenase activity (inferred from electronic annotation from EC).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR006638; Elp3/MiaB/NifB.
IPR010723; HemN_C.
IPR004559; HemN_rel.
IPR007197; Radical_SAM.
Graphical view of domain structure.
Pfam PF06969; HemN_C; 1.
PF04055; Radical_SAM; 1.
Pfam graphical view of domain structure.
SMART SM00729; Elp3; 1.
SMART graphical view of domain structure.
TIGRFAMs TIGR00539; hemN_rel; 1.
BLOCKS P71756.
ProtoNet P71756.
Genome annotation databases
GeneID 885300; -.
925891; -.
GenomeReviews AE000516_GR; MT2457.
AL123456_GR; Rv2388c.
KEGG mtc:MT2457; -.
mtu:Rv2388c; -.
TIGR MT2457; -.
Phylogenomic databases
HOGENOM P71756; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Porphyrin biosynthesis; S-adenosyl-L-methionine.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   375  375     Probable oxygen-independent coproporphyrinogen III oxidase. PRO_0000109944
REGION   68    69  2     S-adenosyl-L-methionine 2 binding (By similarity). 
METAL   15    15        Iron-sulfur (4Fe-4S-S-AdoMet) (By similarity). 
METAL   19    19        Iron-sulfur (4Fe-4S-S-AdoMet) (By similarity). 
METAL   22    22        Iron-sulfur (4Fe-4S-S-AdoMet) (By similarity). 
BINDING   9     9        S-adenosyl-L-methionine 1 (By similarity). 
BINDING   21    21        S-adenosyl-L-methionine 2; via carbonyl oxygen (By similarity). 
BINDING   67    67        S-adenosyl-L-methionine 1; via amide nitrogen and carbonyl oxygen (By similarity). 
BINDING   100   100        S-adenosyl-L-methionine 1 (By similarity). 
BINDING   127   127        S-adenosyl-L-methionine 2 (By similarity). 
BINDING   139   139        S-adenosyl-L-methionine 2 (By similarity). 
BINDING   164   164        S-adenosyl-L-methionine 2 (By similarity). 
Sequence information
Length: 375 AA [This is the length of the unprocessed precursor] Molecular weight: 40334 Da [This is the MW of the unprocessed precursor] CRC64: 6E614EF58AA8FCE9 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MPGQPFGVYL HVPFCLTRCG YCDFNTYTPA QLGGVSPDRW LLALRAELEL AAAKLDAPTV 

        70         80         90        100        110        120 
HTVYVGGGTP SLLGGERLAT LLDMVRDHFV LAPDAEVSTE ANPESTWPEF FATIRAAGYT 

       130        140        150        160        170        180 
RVSLGMQSVA PRVLATLDRV HSPGRAAAAA TEAIAEGFTH VNLDLIYGTP GESDDDLVRS 

       190        200        210        220        230        240 
VDAAVQAGVD HVSAYALVVE HGTALARRVR RGELAAPDDD VLAHRYELVD ARLSAAGFAW 

       250        260        270        280        290        300 
YEVSNWCRPG GECRHNLGYW DGGQWWGAGP GAHGYIGVTR WWNVKHPNTY AEILAGATLP 

       310        320        330        340        350        360 
VAGFEQLGAD ALHTEDVLLK VRLRQGLPLA RLGAAERERA EAVLADGLLD YHGDRLVLTG 

       370 
RGRLLADAVV RTLLG
P71756 in FASTA format

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