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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
TISSUE=Brain;
PubMed=8781233 [NCBI, ExPASy, EBI, Israel, Japan]
Koehler M.,
Hirschberg B.,
Bond C.T.,
Kinzie J.M.,
Marrion N.V.,
Maylie J.,
Adelman J.P.;
"Small-conductance, calcium-activated potassium channels from mammalian brain.";
Science 273:1709-1714(1996).
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[2]
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INTERACTION WITH CALMODULIN.
DOI=10.1038/26758; PubMed=9774106 [NCBI, ExPASy, EBI, Israel, Japan]
Xia X.M.,
Fakler B.,
Rivard A.F.,
Wayman G.,
Johnson-Pais T.,
Keen J.E.,
Ishii T.,
Hirschberg B.,
Bond C.T.,
Lutsenko S.,
Maylie J.,
Adelman J.P.;
"Mechanism of calcium gating in small-conductance calcium-activated potassium channels.";
Nature 395:503-507(1998).
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[3]
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X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 395-490 WITH CALMODULIN.
DOI=10.1038/35074145; PubMed=11323678 [NCBI, ExPASy, EBI, Israel, Japan]
Schumacher M.A.,
Rivard A.F.,
Bachinger H.P.,
Adelman J.P.;
"Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin.";
Nature 410:1120-1124(2001).
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- FUNCTION: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
- SUBUNIT: Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding.
- INTERACTION:
P62161:Calm1; NbExp=1; IntAct=EBI-1031103, EBI-397530;
- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
- TISSUE SPECIFICITY: Brain.
- SIMILARITY: Belongs to the potassium channel KCNN family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 580 AA [This is the length of the unprocessed precursor] |
Molecular weight: 63848 Da [This is the MW of the unprocessed precursor] |
CRC64: F71E0DAF7EEFA8D4 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MSSCRYNGGV MRPLSNLSSS RRNLHEMDSE AQPLQPPASV VGGGGGASSP SAAAAASSSA
70 80 90 100 110 120
PEIVVSKPEH NNSNNLALYG TGGGGSTGGG GGGGGGGGGS GHGSSSGTKS SKKKNQNIGY
130 140 150 160 170 180
KLGHRRALFE KRKRLSDYAL IFGMFGIVVM VIETELSWGA YDKASLYSLA LKCLISLSTI
190 200 210 220 230 240
ILLGLIIVYH AREIQLFMVD NGADDWRIAM TYERIFFICL EILVCAIHPI PGNYTFTWTA
250 260 270 280 290 300
RLAFSYAPST TTADVDIILS IPMFLRLYLI ARVMLLHSKL FTDASSRSIG ALNKINFNTR
310 320 330 340 350 360
FVMKTLMTIC PGTVLLVFSI SLWIIAAWTV RACERYHDQQ DVTSNFLGAM WLISITFLSI
370 380 390 400 410 420
GYGDMVPNTY CGKGVCLLTG IMGAGCTALV VAVVARKLEL TKAEKHVHNF MMDTQLTKRV
430 440 450 460 470 480
KNAAANVLRE TWLIYKNTKL VKKIDHAKVR KHQRKFLQAI HQLRSVKMEQ RKLNDQANTL
490 500 510 520 530 540
VDLAKTQNIM YDMISDLNER SEDFEKRIVT LETKLETLIG SIHALPGLIS QTIRQQQRDF
550 560 570 580
IETQMENYDK HVTYNAERSR SSSRRRRSSS TAPPTSSESS
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P70604 in FASTA format |
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