[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1210/en.137.10.4285; PubMed=8828488 [NCBI, ExPASy, EBI, Israel, Japan] Usdin T.B., Bonner T.I., Harta G., Mezey E.; "Distribution of parathyroid hormone-2 receptor messenger ribonucleic acid in rat."; Endocrinology 137:4285-4297(1996).

Comments

FUNCTION: This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor.
SUBUNIT: Binds to TIPF39/TIP39 (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Abundantly expressed in brain, arterial and cardiac endothelium. Found as well in sperm, in the head of the epididymis. Lower expression is found in vascular smooth muscle, exocrine pancreas, testis and placenta.
SIMILARITY: Belongs to the G-protein coupled receptor 2 family [view classification].

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U55836; AAC52849.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_112351.1; -.

UniGene

Rn.10601

3D structure databases

ModBase

P70555.

Protein family/group databases

GPCRDB

P70555; PTH2R_RAT.

Organism-specific databases

RGD

620612; Pth2r.

Gene expression databases

ArrayExpress

P70555; -.

GermOnline

ENSRNOG00000015259; Rattus norvegicus.

Family and domain databases

InterPro

IPR001879; GPCR_2_extracellular.
IPR000832; GPCR_2_secretin-like.
Graphical view of domain structure.

Pfam

PF00002; 7tm_2; 1.
PF02793; HRM; 1.
Pfam graphical view of domain structure.

PRINTS

PR00249; GPCRSECRETIN.

SMART

SM00008; HormR; 1.
SMART graphical view of domain structure.

PROSITE

PS00649; G_PROTEIN_RECEP_F2_1; 1.
PS00650; G_PROTEIN_RECEP_F2_2; 1.
PS50227; G_PROTEIN_RECEP_F2_3; 1.
PS50261; G_PROTEIN_RECEP_F2_4; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

P70555.

Genome annotation databases

Ensembl

ENSRNOG00000015259; Rattus norvegicus. [Contig view]

GeneID

81753; -.

KEGG

rno:81753; -.

Phylogenomic databases

HOVERGEN

P70555; -.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane; Receptor; Signal; Transducer; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 24`	`24`	`Potential.`
`CHAIN`	`25 546`	`522`	`Parathyroid hormone 2 receptor.`	`PRO_0000012851`
`TOPO_DOM`	`27 143`	`117`	`Extracellular (Potential).`
`TRANSMEM`	`144 167`	`24`	`1 (Potential).`
`TOPO_DOM`	`168 174`	`7`	`Cytoplasmic (Potential).`
`TRANSMEM`	`175 194`	`20`	`2 (Potential).`
`TOPO_DOM`	`195 235`	`41`	`Extracellular (Potential).`
`TRANSMEM`	`236 258`	`23`	`3 (Potential).`
`TOPO_DOM`	`259 273`	`15`	`Cytoplasmic (Potential).`
`TRANSMEM`	`274 295`	`22`	`4 (Potential).`
`TOPO_DOM`	`296 313`	`18`	`Extracellular (Potential).`
`TRANSMEM`	`314 334`	`21`	`5 (Potential).`
`TOPO_DOM`	`335 361`	`27`	`Cytoplasmic (Potential).`
`TRANSMEM`	`362 380`	`19`	`6 (Potential).`
`TOPO_DOM`	`381 391`	`11`	`Extracellular (Potential).`
`TRANSMEM`	`392 414`	`23`	`7 (Potential).`
`TOPO_DOM`	`415 546`	`132`	`Cytoplasmic (Potential).`
`CARBOHYD`	`51 51`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`106 106`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`116 116`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`121 121`		`N-linked (GlcNAc...) (Potential).`

Sequence information

Length: 546 AA [This is the length of the unprocessed precursor]

Molecular weight: 61804 Da [This is the MW of the unprocessed precursor]

CRC64: 2825AE4040313527 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MPWLEALPYI CGWLILRSCL LVGAQLDSDG TITIEEQIVL VMKAKMQCEL NITAQFQEGE 

        70         80         90        100        110        120 
GNCFPEWDGL ICWPRGTAGK TSAMPCPSYV YDFNHKGVAF RHCTPNGTWD FIHGSNKTWA 

       130        140        150        160        170        180 
NYSDCFLQPD INIGKQEFFE NLYILYTVGY SISFGSLAVA ILIIGYFRRL HCTRNYIHLH 

       190        200        210        220        230        240 
LFVSFMLRAX SIFVKDRVAQ AHLGVEALQS LVMQGDLQNF IGGPSVDKSQ YVGCKIAVVM 

       250        260        270        280        290        300 
FIYFLATNYY WILVEGLYLH NLIFVSFFSD TKYLWGFILI GWGFPAVFVV AWAVARATLA 

       310        320        330        340        350        360 
DTRCWELSAG DRWIYXXPIL AAIGLNFILF LNTVRVLATK IWETNAVGHD MRKQYRKLAK 

       370        380        390        400        410        420 
STLVLVLVFG VHYIVFICQP HSFSGLWWEI RMHCELFFNS FQGFFVSIVY CYCNGEVQAE 

       430        440        450        460        470        480 
VKKTWTRWNL SIDWKKAPPC GGHRYGSVLT TVTHSTSSQS QMGPSTRLVL ISSKPAKTAC 

       490        500        510        520        530        540 
RQIDSHVTLP GYVWSSSEQD CQPQSTPEET KKGHGRQEDD SPVGESSRPV AFTIDTEGCK 


GESHPI

P70555 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools