[1]	NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=C57BL/6J; DOI=10.1006/geno.1996.0477; PubMed=8812468 [NCBI, ExPASy, EBI, Israel, Japan] Jang W., Weber J.S., Bashir R., Bushby K., Meisler M.H.; "Aup1, a novel gene on mouse chromosome 6 and human chromosome 2p13."; Genomics 36:366-368(1996).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=FVB/N; TISSUE=Mammary gland; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (By similarity).
SUBUNIT: Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with the cytoplasmic tail of ITGA2B, ITGA1, ITGA2, ITGA5, ITGAV and ITGAM (By similarity).
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type III membrane protein; Cytoplasmic side (By similarity).
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: Belongs to the AUP1 family.
SIMILARITY: Contains 1 CUE domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U41736; AAC52839.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC016485; AAH16485.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00137725; -.

UniGene

Mm.386752

3D structure databases

ModBase

P70295.

PTM databases

PhosphoSite

P70295; -.

Organism-specific databases

MGI

MGI:107789; Aup1.

Gene expression databases

P70295; -.

P70295; -.

MM_AUP1; -.

ENSMUSG00000068328; Mus musculus.

Ontologies

GO:0005789;	Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0008415;	Molecular function: acyltransferase activity (inferred from electronic annotation from InterPro).
GO:0019941;	Biological process: modification-dependent protein catabolic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR002123; Acyltransferase.
IPR003892; CUE.
Graphical view of domain structure.

Pfam

PF02845; CUE; 1.
Pfam graphical view of domain structure.

SMART

SM00546; CUE; 1.
SM00563; PlsC; 1.
SMART graphical view of domain structure.

PROSITE

PS51140; CUE; 1.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

P70295; -.

Genome annotation databases

Ensembl

ENSMUSG00000068328; Mus musculus. [Contig view]

Phylogenomic databases

HOVERGEN

P70295; -.

Other

Aup1; Mus musculus.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Endoplasmic reticulum; Membrane; Phosphoprotein; Transmembrane; Ubl conjugation pathway.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 410`	`410`	`Ancient ubiquitous protein 1.`	`PRO_0000020766`
`TOPO_DOM`	`1 20`	`20`	`Lumenal (Potential).`
`TRANSMEM`	`21 41`	`21`	`Signal-anchor for type III membrane protein (Potential).`
`TOPO_DOM`	`42 410`	`369`	`Cytoplasmic (Potential).`
`DOMAIN`	`296 338`	`43`	`CUE.`
`MOD_RES`	`292 292`		`Phosphoserine (By similarity).`
`MOD_RES`	`356 356`		`Phosphoserine (By similarity).`
`MOD_RES`	`363 363`		`Phosphoserine (By similarity).`
`MOD_RES`	`367 367`		`Phosphothreonine (By similarity).`

Sequence information

Length: 410 AA [This is the length of the unprocessed precursor]

Molecular weight: 46121 Da [This is the MW of the unprocessed precursor]

CRC64: E7D070CEB296BD5B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MEPPPAPGPE RLFDSHRLPS DGFLLLALLL YAPVGLCLLV LRLFLGLHVF LVSCALPDSV 

        70         80         90        100        110        120 
LRRFVVRTMC AVLGLVARQE DSGLRDHRVR VLISNHVTPF DHNIVNLLTT CSTPLLNSPP 

       130        140        150        160        170        180 
SFVCWSRGFM EMDRRVELVE SLKKFCASTR LPPTPLLLFP EEEATNGREG LLRFSSWPFS 

       190        200        210        220        230        240 
IQDVVQPLTL QVQRPLVSVT VSDASWVSEL LWSLFVPFTV YQVRWLHPIR RQLGEESEEF 

       250        260        270        280        290        300 
ALRVQQLVAK ELGQIGTRLT PADKAEHMKR QRHPRLRPQS VQSSFPSPPS PSSDVQLTTL 

       310        320        330        340        350        360 
AHRVKEVLPH VPLNVIQRDL ARTGCVDLTI TNLLEGAVAF MPEDVTEGSQ SPPAPSAPKF 

       370        380        390        400        410 
PSSGLATPQP TALTFAKSSW ARQESLQERK QALYEYARRR FRERQAQEAE

P70295 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools