[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
DOI=10.1006/geno.1996.4556; PubMed=9119407 [NCBI, ExPASy, EBI, Israel, Japan]
Lapenta V.,
Chiurazzi P.,
van der Spek P.J.,
Pizzuti A.,
Hanaoka F.,
Brahe C.;
"SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family.";
Genomics 40:362-367(1997).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain, and Placenta;
PubMed=8806687 [NCBI, ExPASy, EBI, Israel, Japan]
Boddy M.N.,
Howe K.,
Etkin L.D.,
Solomon E.,
Freemont P.S.;
"PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia.";
Oncogene 13:971-982(1996).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1006/geno.1996.0462; PubMed=8812453 [NCBI, ExPASy, EBI, Israel, Japan]
Shen Z.,
Pardington-Purtymun P.E.,
Comeaux J.C.,
Moyzis R.K.,
Chen D.J.;
"UBL1, a human ubiquitin-like protein associating with human RAD51/RAD52 proteins.";
Genomics 36:271-279(1996).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
DOI=10.1016/S0092-8674(00)81862-0; PubMed=9019411 [NCBI, ExPASy, EBI, Israel, Japan]
Mahajan R.,
Delphin C.,
Guan T.,
Gerace L.,
Melchior F.;
"A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2.";
Cell 88:97-107(1997).
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[5]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1083/jcb.135.6.1457; PubMed=8978815 [NCBI, ExPASy, EBI, Israel, Japan]
Matunis M.J.,
Coutavas E.,
Blobel G.;
"A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex.";
J. Cell Biol. 135:1457-1470(1996).
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[6]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Placenta;
PubMed=8906799 [NCBI, ExPASy, EBI, Israel, Japan]
Okura T.,
Gong L.,
Kamitani T.,
Wada T.,
Okura I.,
Wei C.F.,
Chang H.M.,
Yeh E.T.H.;
"Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin.";
J. Immunol. 157:4277-4281(1996).
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[7]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Colon adenocarcinoma;
Shichijo S.,
Itoh K.;
"Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients.";
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
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[8]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N.,
Chen X.,
Rolfs A.,
Halleck A.,
Hines L.,
Eisenstein S.,
Koundinya M.,
Raphael J.,
Moreira D.,
Kelley T.,
LaBaer J.,
Lin Y.,
Phelan M.,
Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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[9]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Ebert L.,
Schick M.,
Neubert P.,
Schatten R.,
Henze S.,
Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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[10]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03466; PubMed=15815621 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W.,
Graves T.A.,
Fulton R.S.,
Fulton L.A.,
Pepin K.H.,
Minx P.,
Wagner-McPherson C.,
Layman D.,
Wylie K.,
Sekhon M.,
Becker M.C.,
Fewell G.A.,
Delehaunty K.D.,
Miner T.L.,
Nash W.E.,
Kremitzki C.,
Oddy L.,
Du H.,
Sun H., ![]()
Bradshaw-Cordum H.,
Ali J.,
Carter J.,
Cordes M.,
Harris A.,
Isak A.,
van Brunt A.,
Nguyen C.,
Du F.,
Courtney L.,
Kalicki J.,
Ozersky P.,
Abbott S.,
Armstrong J.,
Belter E.A.,
Caruso L.,
Cedroni M.,
Cotton M.,
Davidson T.,
Desai A.,
Elliott G.,
Erb T.,
Fronick C.,
Gaige T.,
Haakenson W.,
Haglund K.,
Holmes A.,
Harkins R.,
Kim K.,
Kruchowski S.S.,
Strong C.M.,
Grewal N.,
Goyea E.,
Hou S.,
Levy A.,
Martinka S.,
Mead K.,
McLellan M.D.,
Meyer R.,
Randall-Maher J.,
Tomlinson C.,
Dauphin-Kohlberg S.,
Kozlowicz-Reilly A.,
Shah N.,
Swearengen-Shahid S.,
Snider J.,
Strong J.T.,
Thompson J.,
Yoakum M.,
Leonard S.,
Pearman C.,
Trani L.,
Radionenko M.,
Waligorski J.E.,
Wang C.,
Rock S.M.,
Tin-Wollam A.-M.,
Maupin R.,
Latreille P.,
Wendl M.C.,
Yang S.-P.,
Pohl C.,
Wallis J.W.,
Spieth J.,
Bieri T.A.,
Berkowicz N.,
Nelson J.O.,
Osborne J.,
Ding L.,
Meyer R.,
Sabo A.,
Shotland Y.,
Sinha P.,
Wohldmann P.E.,
Cook L.L.,
Hickenbotham M.T.,
Eldred J.,
Williams D.,
Jones T.A.,
She X.,
Ciccarelli F.D.,
Izaurralde E.,
Taylor J.,
Schmutz J.,
Myers R.M.,
Cox D.R.,
Huang X.,
McPherson J.D.,
Mardis E.R.,
Clifton S.W.,
Warren W.C.,
Chinwalla A.T.,
Eddy S.R.,
Marra M.A.,
Ovcharenko I.,
Furey T.S.,
Miller W.,
Eichler E.E.,
Bork P.,
Suyama M.,
Torrents D.,
Waterston R.H.,
Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.";
Nature 434:724-731(2005).
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[11]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[12]
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FUNCTION, SUBCELLULAR LOCATION, AND PROTEOLYTIC CLEAVAGE.
DOI=10.1074/jbc.272.22.14001; PubMed=9162015 [NCBI, ExPASy, EBI, Israel, Japan]
Kamitani T.,
Nguyen H.P.,
Yeh E.T.H.;
"Preferential modification of nuclear proteins by a novel ubiquitin-like molecule.";
J. Biol. Chem. 272:14001-14004(1997).
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[13]
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SUBCELLULAR LOCATION.
PubMed=10574707 [NCBI, ExPASy, EBI, Israel, Japan]
Everett R.D.,
Lomonte P.,
Sternsdorf T.,
van Driel R.,
Orr A.;
"Cell cycle regulation of PML modification and ND10 composition.";
J. Cell Sci. 112:4581-4588(1999).
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[14]
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INTERACTION WITH HIPK3; CHD3; PIAS1; EXOSC9 AND TDG.
DOI=10.1074/jbc.M004293200; PubMed=10961991 [NCBI, ExPASy, EBI, Israel, Japan]
Minty A.,
Dumont X.,
Kaghad M.,
Caput D.;
"Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif.";
J. Biol. Chem. 275:36316-36323(2000).
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[15]
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SUBCELLULAR LOCATION.
DOI=10.1016/S0378-1119(02)00843-0; PubMed=12383504 [NCBI, ExPASy, EBI, Israel, Japan]
Su H.-L.,
Li S.S.-L.;
"Molecular features of human ubiquitin-like SUMO genes and their encoded proteins.";
Gene 296:65-73(2002).
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[16]
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INTERACTION WITH UBE2I.
DOI=10.1021/bi0345283; PubMed=12924945 [NCBI, ExPASy, EBI, Israel, Japan]
Tatham M.H.,
Kim S.,
Yu B.,
Jaffray E.,
Song J.,
Zheng J.,
Rodriguez M.S.,
Hay R.T.,
Chen Y.;
"Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation.";
Biochemistry 42:9959-9969(2003).
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[17]
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INTERACTION WITH HIPK2.
DOI=10.1016/S0014-4827(02)00025-3; PubMed=12565818 [NCBI, ExPASy, EBI, Israel, Japan]
Engelhardt O.G.,
Boutell C.,
Orr A.,
Ullrich E.,
Haller O.,
Everett R.D.;
"The homeodomain-interacting kinase PKM (HIPK-2) modifies ND10 through both its kinase domain and a SUMO-1 interaction motif and alters the posttranslational modification of PML.";
Exp. Cell Res. 283:36-50(2003).
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[18]
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CLEAVAGE.
DOI=10.1042/BJ20041210; PubMed=15487983 [NCBI, ExPASy, EBI, Israel, Japan]
Xu Z.,
Au S.W.N.;
"Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1.";
Biochem. J. 386:325-330(2005).
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[19]
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INTERACTION WITH RANBP2.
DOI=10.1038/nsmb878; PubMed=15608651 [NCBI, ExPASy, EBI, Israel, Japan]
Tatham M.H.,
Kim S.,
Jaffray E.,
Song J.,
Chen Y.,
Hay R.T.;
"Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection.";
Nat. Struct. Mol. Biol. 12:67-74(2005).
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[20]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V.,
Blagoev B.,
Gnad F.,
Macek B.,
Kumar C.,
Mortensen P.,
Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
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[21]
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INTERACTION WITH PARK2.
DOI=10.1002/jnr.21041; PubMed=16955485 [NCBI, ExPASy, EBI, Israel, Japan]
Um J.W.,
Chung K.C.;
"Functional modulation of parkin through physical interaction with SUMO-1.";
J. Neurosci. Res. 84:1543-1554(2006).
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[22]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, AND MASS SPECTROMETRY.
DOI=10.1016/j.molcel.2008.07.007; PubMed=18691976 [NCBI, ExPASy, EBI, Israel, Japan]
Daub H.,
Olsen J.V.,
Bairlein M.,
Gnad F.,
Oppermann F.S.,
Korner R.,
Greff Z.,
Keri G.,
Stemmann O.,
Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
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[23]
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IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J.,
Superti-Furga G.,
Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
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[24]
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STRUCTURE BY NMR.
DOI=10.1006/jmbi.1998.1839; PubMed=9654451 [NCBI, ExPASy, EBI, Israel, Japan]
Bayer P.,
Arndt A.,
Metzger S.,
Mahajan R.,
Melchior F.,
Jaenicke R.,
Becker J.;
"Structure determination of the small ubiquitin-related modifier SUMO-1.";
J. Mol. Biol. 280:275-286(1998).
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[25]
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X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 18-97 IN COMPLEX WITH SENP2, AND CLEAVAGE.
DOI=10.1016/j.str.2004.05.023; PubMed=15296745 [NCBI, ExPASy, EBI, Israel, Japan]
Reverter D.,
Lima C.D.;
"A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex.";
Structure 12:1519-1531(2004).
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[26]
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X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 1-97 IN COMPLEX WITH SAE1; SAE2 AND ATP.
DOI=10.1038/sj.emboj.7600552; PubMed=15660128 [NCBI, ExPASy, EBI, Israel, Japan]
Lois L.M.,
Lima C.D.;
"Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1.";
EMBO J. 24:439-451(2005).
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[27]
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STRUCTURE BY NMR OF 1-97 IN COMPLEX WITH PIAS2, AND MUTAGENESIS OF PHE-36.
DOI=10.1074/jbc.M507059200; PubMed=16204249 [NCBI, ExPASy, EBI, Israel, Japan]
Song J.,
Zhang Z.,
Hu W.,
Chen Y.;
"Small ubiquitin-like modifier (SUMO) recognition of a SUMO binding motif: a reversal of the bound orientation.";
J. Biol. Chem. 280:40122-40129(2005).
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[28]
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X-RAY CRYSTALLOGRAPHY (3.01 ANGSTROMS) OF 18-97 IN COMPLEX WITH UBE2I; RANGAP1 AND RANBP2.
DOI=10.1038/nature03588; PubMed=15931224 [NCBI, ExPASy, EBI, Israel, Japan]
Reverter D.,
Lima C.D.;
"Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex.";
Nature 435:687-692(2005).
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[29]
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X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1-97 CONJUGATED TO TDG.
DOI=10.1038/nature03634; PubMed=15959518 [NCBI, ExPASy, EBI, Israel, Japan]
Baba D.,
Maita N.,
Jee J.-G.,
Uchimura Y.,
Saitoh H.,
Sugasawa K.,
Hanaoka F.,
Tochio H.,
Hiroaki H.,
Shirakawa M.;
"Crystal structure of thymine DNA glycosylase conjugated to SUMO-1.";
Nature 435:979-982(2005).
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[30]
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X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 21-97 CONJUGATED TO HIP2.
DOI=10.1038/nsmb903; PubMed=15723079 [NCBI, ExPASy, EBI, Israel, Japan]
Pichler A.,
Knipscheer P.,
Oberhofer E.,
van Dijk W.J.,
Koerner R.,
Olsen J.V.,
Jentsch S.,
Melchior F.,
Sixma T.K.;
"SUMO modification of the ubiquitin-conjugating enzyme E2-25K.";
Nat. Struct. Mol. Biol. 12:264-269(2005).
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[31]
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X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) IN COMPLEX WITH SENP1.
DOI=10.1042/BJ20060526; PubMed=16712526 [NCBI, ExPASy, EBI, Israel, Japan]
Xu Z.,
Chau S.F.,
Lam K.H.,
Chan H.Y.,
Ng T.B.,
Au S.W.N.;
"Crystal structure of the SENP1 mutant C603S-SUMO complex reveals the hydrolytic mechanism of SUMO-specific protease.";
Biochem. J. 398:345-352(2006).
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[32]
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X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) IN COMPLEX WITH SENP1.
Dong C.,
Shen L.,
Taitham M.,
Hay R.T.,
Naismith J.H.;
"Complexes of SEN protease.";
Submitted (AUG-2006) to the PDB data bank.
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