[1]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). TISSUE=Retina; DOI=10.1073/pnas.93.18.9850; PubMed=8790420 [NCBI, ExPASy, EBI, Israel, Japan] Smallwood P.M., Munoz-Sanjuan I., Tong P., Macke J.P., Hendry S.H., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.; "Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development."; Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996).
[2]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). TISSUE=Heart; DOI=10.1006/bbrc.1999.0178; PubMed=10049777 [NCBI, ExPASy, EBI, Israel, Japan] Kok L.D.S., Tsui S.K.W., Waye M.M.Y., Liew C.C., Lee C.-Y., Fung K.-P.; "Cloning and characterization of a cDNA encoding a novel fibroblast growth factor preferentially expressed in human heart."; Biochem. Biophys. Res. Commun. 255:717-721(1999).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). TISSUE=Brain; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: Probably involved in nervous system development and function.
SUBUNIT: Interacts with the C-terminal region of SCN9A (By similarity).
SUBCELLULAR LOCATION: Nucleus (Probable).
ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing.

Name 1

Isoform ID P61328-1

This is the isoform sequence displayed in this entry.

Name 2

Synonyms FGF-12B

Isoform ID P61328-2

Features which should be applied to build the isoform sequence: VSP_010222.
TISSUE SPECIFICITY: Brain, eye and testis; highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and in a segmental pattern of the body wall; in adult olfactory bulb, less in cerebellum, deep cerebellar nuclei, cortex and multiple midbrain structures.
SIMILARITY: Belongs to the heparin-binding growth factors family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U66197; AAB18913.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U76381; AAB18786.3; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC022524; AAH22524.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

JG0184; JG0184.

NP_066360.1; -.

3D structure databases

PDB

1Q1U; X-ray; 1.70 A; A=67-205.

[ExPASy / RCSB / EBI]

1Q1U; -.

PTM databases

P61328; -.

Organism-specific databases

HIX0003950; -.

HGNC:3668; FGF12.

601513; gene. [NCBI / EBI]

PharmGKB

PA28108; -.

GeneCards

P61328.

Gene expression databases

ArrayExpress

P61328; -.

CleanEx

HS_FGF12; -.

GermOnline

ENSG00000114279; Homo sapiens.

Ontologies

GO:0005615;	Cellular component: extracellular space (traceable author statement from ProtInc).
GO:0005634;	Cellular component: nucleus (traceable author statement from ProtInc).
GO:0008083;	Molecular function: growth factor activity (traceable author statement from ProtInc).
GO:0007267;	Biological process: cell-cell signaling (traceable author statement from ProtInc).
GO:0007507;	Biological process: heart development (traceable author statement from ProtInc).
GO:0007399;	Biological process: nervous system development (traceable author statement from ProtInc).
GO:0007165;	Biological process: signal transduction (traceable author statement from ProtInc).
QuickGo view.

Family and domain databases

InterPro

IPR002209; GF_heparin_bd.
IPR002348; IL1_HBGF.
Graphical view of domain structure.

PANTHER

PTHR11486; IL1_HBGF; 1.

Pfam

PF00167; FGF; 1.
Pfam graphical view of domain structure.

PRINTS

PR00263; HBGFFGF.
PR00262; IL1HBGF.

ProDom

PD000831; IL1_HBGF; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00442; FGF; 1.
SMART graphical view of domain structure.

PROSITE

PS00247; HBGF_FGF; 1.

BLOCKS

P61328.

Genome annotation databases

Ensembl

ENSG00000114279; Homo sapiens. [Contig view]

GeneID

2257; -.

KEGG

hsa:2257; -.

Phylogenomic databases

HOGENOM

P61328; -.

HOVERGEN

P61328; -.

Other

FGF12; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

3D-structure; Alternative splicing; Growth factor; Nucleus.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 243`	`243`	`Fibroblast growth factor 12.`	`PRO_0000147604`
`MOTIF`	`11 38`	`28`	`Bipartite nuclear localization signal (Potential).`
`VAR_SEQ`	`1 66`		`MAAAIASSLIRQKRQARESNSDRVSASKRRSSPSKDGRSL` `CERHVLGVFSKVRFCSGRKRPVRRRP -> MESK (in isoform 2).`	`VSP_010222`
`CONFLICT`	`190 190`		`K -> E (in Ref. 2; AAB18786).`
`CONFLICT`	`211 211`		`P -> Q (in Ref. 3; AAH22524).`
`CONFLICT`	`229 243`		`TPTMNGGKVVNQDST -> HHHDGGKL (in Ref. 2).`
`STRAND`	`73 79`	`7`
`TURN`	`80 82`	`3`
`STRAND`	`83 87`	`5`
`STRAND`	`93 97`	`5`
`HELIX`	`102 104`	`3`
`STRAND`	`106 112`	`7`
`STRAND`	`115 120`	`6`
`TURN`	`121 123`	`3`
`STRAND`	`126 129`	`4`
`STRAND`	`135 140`	`6`
`HELIX`	`143 145`	`3`
`STRAND`	`147 152`	`6`
`TURN`	`153 155`	`3`
`STRAND`	`156 165`	`10`
`TURN`	`167 169`	`3`
`STRAND`	`172 174`	`3`
`STRAND`	`181 183`	`3`
`HELIX`	`186 188`	`3`
`HELIX`	`194 196`	`3`
`STRAND`	`198 202`	`5`

Sequence information

Length: 243 AA [This is the length of the unprocessed precursor]

Molecular weight: 27399 Da [This is the MW of the unprocessed precursor]

CRC64: 773ED10B5BDD033C [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAAAIASSLI RQKRQARESN SDRVSASKRR SSPSKDGRSL CERHVLGVFS KVRFCSGRKR 

        70         80         90        100        110        120 
PVRRRPEPQL KGIVTRLFSQ QGYFLQMHPD GTIDGTKDEN SDYTLFNLIP VGLRVVAIQG 

       130        140        150        160        170        180 
VKASLYVAMN GEGYLYSSDV FTPECKFKES VFENYYVIYS STLYRQQESG RAWFLGLNKE 

       190        200        210        220        230        240 
GQIMKGNRVK KTKPSSHFVP KPIEVCMYRE PSLHEIGEKQ GRSRKSSGTP TMNGGKVVNQ 


DST

P61328 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools