[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1016/j.ygeno.2003.09.016; PubMed=15028296 [NCBI, ExPASy, EBI, Israel, Japan] Hamilton B.A.; "Alpha-synuclein A53T substitution associated with Parkinson disease also marks the divergence of Old World and New World primates."; Genomics 83:739-742(2004).

Comments

FUNCTION: May be involved in the regulation of dopamine release and transport (By similarity).
SUBUNIT: Interacts with UCHL1 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
PTM: Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress (By similarity).
PTM: Ubiquitinated. The predominant conjugate is the diubiquitinated form (By similarity).
SIMILARITY: Belongs to the synuclein family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AY362334; AAQ85073.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY362330; AAQ85073.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY362331; AAQ85073.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY362332; AAQ85073.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY362333; AAQ85073.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

SMR

P61141; 1-140.

ModBase

P61141.

Family and domain databases

InterPro

IPR001058; Synuclein.
IPR002460; Synuclein_alpha.
Graphical view of domain structure.

Gene3D

G3DSA:1.10.287.700; Synuclein; 1.

PANTHER

PTHR13820; Synuclein; 1.

Pfam

PF01387; Synuclein; 1.
Pfam graphical view of domain structure.

PRINTS

PR01212; ASYNUCLEIN.
PR01211; SYNUCLEIN.

ProDom

PD010631; Synuclein; 1.
[Domain structure / List of seq. sharing at least 1 domain]

BLOCKS

P61141.

Phylogenomic databases

HOVERGEN

P61141; -.

Other

ProtoNet

P61141.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Phosphoprotein; Repeat; Ubl conjugation.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 140`	`140`	`Alpha-synuclein.`	`PRO_0000184023`
`MOD_RES`	`125 125`		`Phosphotyrosine (By similarity).`

Sequence information

Length: 140 AA [This is the length of the unprocessed precursor]

Molecular weight: 14446 Da [This is the MW of the unprocessed precursor]

CRC64: 89BDCDD1E2FB649E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK 

        70         80         90        100        110        120 
EQVTSVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDHS GKSEEGAPQE GILEDMPVDP 

       130        140 
DNEAYEMPSE EGYQDYEPEA

P61141 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools