ID   GBRL2_MOUSE             Reviewed;         117 AA.
AC   P60521; O08765; Q9DCP8; Q9UQF7;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 1.
DT   02-SEP-2008, entry version 43.
DE   RecName: Full=Gamma-aminobutyric acid receptor-associated protein-like 2;
DE   AltName: Full=GABA(A) receptor-associated protein-like 2;
DE   AltName: Full=Golgi-associated ATPase enhancer of 16 kDa;
DE            Short=GATE-16;
GN   Name=Gabarapl2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   MEDLINE=21309076; PubMed=11414770; DOI=10.1006/geno.2001.6555;
RA   Xin Y., Yu L., Chen Z., Zheng L., Fu Q., Jiang J., Zhang P., Gong R.,
RA   Zhao S.;
RT   "Cloning, expression patterns, and chromosome localization of three
RT   human and two mouse homologues of GABA(A) receptor-associated
RT   protein.";
RL   Genomics 74:408-413(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Hippocampus, and Kidney;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain, and Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Involved in intra-Golgi traffic. Modulates intra-Golgi
CC       transport through coupling between NSF activity and SNAREs
CC       activation. It first stimulates the ATPase activity of NSF which
CC       in turn stimulates the association with GOSR1 (By similarity).
CC   -!- SUBUNIT: Monomer. Interacts with GABRG2, ULK1, NSF, GOSR1 and
CC       beta-tubulin (By similarity).
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus (By similarity).
CC   -!- TISSUE SPECIFICITY: Ubiquitous. A high level expression is seen in
CC       brain, thymus, lung, heart, liver and kidney.
CC   -!- PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the MAP1 LC3 family.
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DR   EMBL; AF190644; AAK16238.1; -; mRNA.
DR   EMBL; AK002596; BAB22217.1; -; mRNA.
DR   EMBL; AK049819; BAC33933.1; -; mRNA.
DR   EMBL; BC026798; AAH26798.1; -; mRNA.
DR   EMBL; BC081436; AAH81436.1; -; mRNA.
DR   RefSeq; NP_080969.2; -.
DR   UniGene; Mm.371666; -.
DR   SMR; P60521; 1-117.
DR   PhosphoSite; P60521; -.
DR   Ensembl; ENSMUSG00000031950; Mus musculus.
DR   GeneID; 93739; -.
DR   KEGG; mmu:93739; -.
DR   MGI; MGI:1890602; Gabarapl2.
DR   HOGENOM; P60521; -.
DR   HOVERGEN; P60521; -.
DR   ArrayExpress; P60521; -.
DR   GermOnline; ENSMUSG00000031950; Mus musculus.
DR   GO; GO:0000139; C:Golgi membrane; IDA:MGI.
DR   InterPro; IPR004241; MAP1_LC3.
DR   PANTHER; PTHR10969; MAP1_LC3; 1.
DR   Pfam; PF02991; MAP1_LC3; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Phosphoprotein; Protein transport; Transport.
FT   CHAIN         1    117       Gamma-aminobutyric acid receptor-
FT                                associated protein-like 2.
FT                                /FTId=PRO_0000212374.
FT   REGION        1     22       Interaction with beta-tubulin (By
FT                                similarity).
FT   REGION       36     68       Interaction with GABRG2 (Potential).
FT   MOD_RES      10     10       Phosphoserine (By similarity).
FT   MOD_RES      39     39       Phosphoserine (By similarity).
FT   CONFLICT     83     83       T -> A (in Ref. 2; BAB22217).
SQ   SEQUENCE   117 AA;  13667 MW;  17ACB540FD5B975B CRC64;
     MKWMFKEDHS LEHRCVESAK IRAKYPDRVP VIVEKVSGSQ IVDIDKRKYL VPSDITVAQF
     MWIIRKRIQL PSEKAIFLFV DKTVPQSSLT MGQLYEKEKD EDGFLYVAYS GENTFGF
//