[1]
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NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INTERACTION WITH ULK1.
TISSUE=Frontal cortex;
DOI=10.1016/S0169-328X(00)00218-7; PubMed=11146101 [NCBI, ExPASy, EBI, Israel, Japan]
Okazaki N.,
Yan J.,
Yuasa S.,
Ueno T.,
Kominami E.,
Masuho Y.,
Koga H.,
Muramatsu M.-A.;
"Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation.";
Brain Res. Mol. Brain Res. 85:1-12(2000).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
DOI=10.1006/geno.2001.6555; PubMed=11414770 [NCBI, ExPASy, EBI, Israel, Japan]
Xin Y.,
Yu L.,
Chen Z.,
Zheng L.,
Fu Q.,
Jiang J.,
Zhang P.,
Gong R.,
Zhao S.;
"Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein.";
Genomics 74:408-413(2001).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA].
Storch S.,
Braulke T.;
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
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[4]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Pituitary;
Song H.,
Peng Y.,
Yu Y.,
Fu G.,
Mao M.,
Zhang Q.,
Zhu H.,
Li G.,
Luo M.,
Chen J.,
Hu R.;
"Human GEF2 homolog gene.";
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain, and Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[6]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0611217104; PubMed=17287340 [NCBI, ExPASy, EBI, Israel, Japan]
Molina H.,
Horn D.M.,
Tang N.,
Mathivanan S.,
Pandey A.;
"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.";
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
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[7]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39, AND MASS SPECTROMETRY.
DOI=10.1126/science.1140321; PubMed=17525332 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuoka S.,
Ballif B.A.,
Smogorzewska A.,
McDonald E.R. III,
Hurov K.E.,
Luo J.,
Bakalarski C.E.,
Zhao Z.,
Solimini N.,
Lerenthal Y.,
Shiloh Y.,
Gygi S.P.,
Elledge S.J.;
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.";
Science 316:1160-1166(2007).
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- FUNCTION: Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity).
- SUBUNIT: Monomer. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin (By similarity). Interacts with ULK1.
- INTERACTION:
Q9NT62:ATG3; NbExp=1; IntAct=EBI-720116, EBI-988094;
Q9Y4P1:ATG4B; NbExp=1; IntAct=EBI-720116, EBI-712014;
Q04637:EIF4G1; NbExp=1; IntAct=EBI-720116, EBI-73711;
P69891:HBG1; NbExp=1; IntAct=EBI-720116, EBI-1056789;
Q8WZA9:IRGQ; NbExp=1; IntAct=EBI-720116, EBI-1055331;
P42704:LRPPRC; NbExp=1; IntAct=EBI-720116, EBI-1050853;
Q8TD19:NEK9; NbExp=1; IntAct=EBI-720116, EBI-1044009;
P21796:VDAC1; NbExp=1; IntAct=EBI-720116, EBI-354158;
P15311:VIL2; NbExp=1; IntAct=EBI-720116, EBI-1056902;
- SUBCELLULAR LOCATION: Golgi apparatus (By similarity).
- TISSUE SPECIFICITY: Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine.
- PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
- SIMILARITY: Belongs to the MAP1 LC3 family.
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