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UniProtKB/Swiss-Prot entry P59626

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRDA_ENTFA
Primary accession number P59626
Secondary accession numbers None
Integrated into Swiss-Prot on April 23, 2003
Sequence was last modified on April 23, 2003 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 48)
Name and origin of the protein
Protein name Dihydroorotate dehydrogenase A
Synonyms EC 1.3.3.1
Dihydroorotate oxidase A
DHOdehase A
DHODase A
DHOD A
Gene name
Name: pyrDA
Synonyms: pydA, pyrD-1
OrderedLocusNames: EF_0285
From
Enterococcus faecalis (Streptococcus faecalis) [TaxID: 1351] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Enterococcaceae; Enterococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=V583 / ATCC 700802;
DOI=10.1126/science.1080613; PubMed=12663927 [NCBI, ExPASy, EBI, Israel, Japan]
Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R., Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C., Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M., Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
"Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis.";
Science 299:2071-2074(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE016830; AAO80148.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_814077.1; -.
3D structure databases
HSSP P54321; 2DOR. [HSSP ENTRY / PDB]
ModBase P59626.
Enzyme and pathway databases
BioCyc EFAE226185:EF_0285-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004158; Molecular function: dihydroorotate oxidase activity (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_00224; -; 1.
PBIL [Tree]
InterPro IPR013785; Aldolase_TIM.
IPR012135; DHO_DHase_1_2.
IPR005720; DHO_DHase_1_core.
IPR001295; Dihydroorotate_DHase_core.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF01180; DHO_dh; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000164; DHO_oxidase; 1.
TIGRFAMs TIGR01037; pyrD_sub1_fam; 1.
PROSITE PS00911; DHODEHASE_1; 1.
PS00912; DHODEHASE_2; FALSE_NEG.
BLOCKS P59626.
ProtoNet P59626.
Genome annotation databases
GeneID 1199203; -.
GenomeReviews AE016830_GR; EF_0285.
KEGG efa:EF0285; -.
NMPDR fig|226185.1.peg.263; -.
TIGR EF_0285; -.
Phylogenomic databases
HOGENOM P59626; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Flavoprotein; FMN; Oxidoreductase; Pyrimidine biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   311  311     Dihydroorotate dehydrogenase A. PRO_0000148390
ACT_SITE   130   130        Nucleophile (By similarity). 
Sequence information
Length: 311 AA [This is the length of the unprocessed precursor] Molecular weight: 34477 Da [This is the MW of the unprocessed precursor] CRC64: A534C74755E914CD [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDISVEFSGH KLANVLMNAS GIHCMTIKEM DELAASQAGA FVAKTATPNP RQGNEEPRYF 

        70         80         90        100        110        120 
DTPLGSINSM GLPNLGIDYY LDYQIARQKE FPEELRFLSV SGMNYEENIA ILKKVQESEY 

       130        140        150        160        170        180 
TGVTEFNLSC PNLPGKPQIA YDFELTEKLL TEVFQFFTKP LGVKLPPFFD IAHFDAMAEI 

       190        200        210        220        230        240 
LNKFPLVYVN SINSIGNGLY IDSDKEEVVI KPKGGFGGLG GEYVKPTALA NVRAFAQRLK 

       250        260        270        280        290        300 
PEIKIIGTGG ITCGKDVFEH LLCGATLVQV GTQLHQEGPQ VFERLAKELQ EIMAAKGYES 

       310 
IEEFRGKLKE M
P59626 in FASTA format

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